Search Results - "Decourt, Boris"

Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease by Decourt, Boris, Lahiri, Debomoy K, Sabbagh, Marwan N

“…Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no therapeutic intervention is available to stop the progression of the…”
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Critical Appraisal of Amyloid Lowering Agents in AD by Decourt, Boris, Boumelhem, Fadel, Pope, Evans D., Shi, Jiong, Mari, Zoltan, Sabbagh, Marwan Noel

“…Purpose of Review According to the amyloid cascade hypothesis, removing amyloid beta (Aβ) should cure Alzheimer’s disease (AD). In the past three decades, many…”
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Passive Anti-amyloid Beta Monoclonal Antibodies: Lessons Learned over Past 20 Years by Wicker, Alexandra, Shriram, Jahnavi, Decourt, Boris, Sabbagh, Marwan Noel

“…Alzheimer’s disease (AD) is a neurodegenerative disorder that significantly impairs cognitive and functional abilities, placing a substantial burden on both…”
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Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones by He, Yingpei, Ren, Yuan, Wu, Bingbing, Decourt, Boris, Lee, Aih Cheun, Taylor, Aaron, Suter, Daniel M

“…Src tyrosine kinases have been implicated in axonal growth and guidance; however, the underlying cellular mechanisms are not well understood. Specifically, it…”
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Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer's Disease by Adem, Muna A, Decourt, Boris, Sabbagh, Marwan N

“…Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are chronic, progressive disorders affecting the elderly, which fosters global healthcare concern…”
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Navigating the Landscape of Plasma Biomarkers in Alzheimer's Disease: Focus on Past, Present, and Future Clinical Applications by Ankeny, Sarrah E., Bacci, Julia R., Decourt, Boris, Sabbagh, Marwan N., Mielke, Michelle M.

“…As the prevalence of Alzheimer’s disease (AD) and its impact on healthcare systems increase, developing tools for accurate diagnosis and monitoring of disease…”
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Pharmacotherapies for the Treatment of Progressive Supranuclear Palsy: A Narrative Review by Dunning, Elise E., Decourt, Boris, Zawia, Nasser H., Shill, Holly A., Sabbagh, Marwan N.

“…Progressive supranuclear palsy (PSP) is a neurodegenerative disorder resulting from the deposition of misfolded and neurotoxic forms of tau protein in specific…”
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Poor Safety and Tolerability Hamper Reaching a Potentially Therapeutic Dose in the Use of Thalidomide for Alzheimer's Disease: Results from a Double-Blind, Placebo-Controlled Trial by Decourt, Boris, Drumm-Gurnee, Denise, Wilson, Jeffrey, Jacobson, Sandra, Belden, Christine, Sirrel, Sherye, Ahmadi, Michael, Shill, Holly, Powell, Jessica, Walker, Aaron, Gonzales, Amanda, Macias, Mimi, Sabbagh, Marwan N

“…To date there is no cure for Alzheimer's disease (AD). After amyloid beta immunotherapies have failed to meet primary endpoints of slowing cognitive decline in…”
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Is diabetes associated with increased pathological burden in Alzheimer's disease? by Sadrolashrafi, Kaviyon, Craft, Suzanne, Decourt, Boris, Adem, Abdu, Wilson, Jeffrey R., Miller, Justin, Sabbagh, Marwan N.

“…Introduction We examined the association between Alzheimer's disease (AD) and type 2 diabetes mellitus (DM) and hypothesized that diabetes is associated with…”
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BACE1 levels by APOE genotype in non-demented and Alzheimer's post-mortem brains by Decourt, Boris, Gonzales, Amanda, Beach, Thomas G, Malek-Ahmadi, Michael, Walker, Aaron, Sue, Lucia, Walker, Douglas G, Sabbagh, Marwan N

“…The APOE genotype is a known susceptibility factor for Alzheimer's disease (AD). It is apparent that the presence of the APOE ε40 allele increases the risk for…”
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Microtubule-mediated Src tyrosine kinase trafficking in neuronal growth cones by Wu, Bingbing, Decourt, Boris, Zabidi, Muhammad A, Wuethrich, Levi T, Kim, William H, Zhou, Zhigang, MacIsaac, Keira, Suter, Daniel M

“…Src family tyrosine kinases are important signaling enzymes in the neuronal growth cone, and they have been implicated in axon guidance; however, the detailed…”
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The importance of genomics in advancing the treatment of dementia by Decourt, Boris, Sabbagh, Marwan N.

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Integration of canonical biomarkers in the diagnosis of preclinical Alzheimer disease by Sabbagh, Marwan N., Decourt, Boris

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Inhibition of rat liver fibrogenesis through noradrenergic antagonism by Dubuisson, Liliane, Desmoulière, Alexis, Decourt, Boris, Evadé, Laetitia, Bedin, Christiane, Boussarie, Liliane, Barrier, Laurence, Vidaud, Michel, Rosenbaum, Jean

“…The effect of adrenergic innervation and/or circulating catecholamines on the function of liver fibrogenic cells is poorly understood. Our aim was to…”
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COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease by Sabbagh, Marwan N, Decourt, Boris

“…Evidence from in vitro and in vivo studies demonstrates that amyloid beta (Aβ) oligomers have potent, broad-spectrum antimicrobial properties created by…”
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The importance of genomics in advancing the diagnosis and treatment of dementia by Decourt, Boris, Sabbagh, Marwan N

“…[...]comorbidities, such as cardiovascular disease, are often unknown or not reported, meaning that the molecular pathways identified by GWAS might reflect…”
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Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease by Vitek, Grace E, Decourt, Boris, Sabbagh, Marwan N

“…Nearly a dozen monoclonal antibodies (mAbs) directed against beta-amyloid (Aβ) have been developed for the treatment of Alzheimer disease (AD), and most of…”
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Biomarker-based diagnosis of preclinical Alzheimer disease: time for the clinic? by Sabbagh, Marwan N., DeCourt, Boris

“…Findings from a worldwide cohort of cognitively unimpaired individuals demonstrate that the presence of two canonical Alzheimer disease biomarkers — amyloid…”
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Mclena‐1: A Phase II Clinical Trial for the Assessment of Safety, Tolerability, and Efficacy of Lenalidomide in Patients with Mild Cognitive Impairment Due to Alzheimer’s Disease; Interim progress by Decourt, Boris, Wilson, Jeffrey, Dumitrescu, Liliana, Ritter, Aaron, Sabbagh, Marwan

“…Background Accumulating evidence indicates that inflammation mediated by tumor necrosis factor alpha (TNF alpha), interleukins (e.g. IL‐1 beta, IL‐2, and…”
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Tau immunotherapies for Alzheimer's disease by Hoskin, Justin L, Sabbagh, Marwan Noel, Al-Hasan, Yazan, Decourt, Boris

“…Alzheimer's dementia (AD) is the most common form of dementia in the World. Pathologically, it is characterized by extracellular β-amyloid plaques and…”
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