Search Results - "Decottignies, Anabelle"

Microhomology-mediated end joining in fission yeast is repressed by Pku70 and relies on genes involved in homologous recombination by Decottignies, A

“…Two DNA repair pathways are known to mediate DNA double-strand-break (DSB) repair: homologous recombination (HR) and nonhomologous end joining (NHEJ). In…”
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Physical Activity and Nutrition: Two Promising Strategies for Telomere Maintenance? by Balan, Estelle, Decottignies, Anabelle, Deldicque, Louise

“…As the world demographic structure is getting older, highlighting strategies to counteract age-related diseases is a major public health concern. Telomeres are…”
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Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin by Episkopou, Harikleia, Draskovic, Irena, Van Beneden, Amandine, Tilman, Gaëlle, Mattiussi, Marina, Gobin, Matthieu, Arnoult, Nausica, Londoño-Vallejo, Arturo, Decottignies, Anabelle

“…Proper telomeric chromatin configuration is thought to be essential for telomere homeostasis and stability. Previous studies in mouse suggested that loss of…”
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Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators by Scheibe, Marion, Arnoult, Nausica, Kappei, Dennis, Buchholz, Frank, Decottignies, Anabelle, Butter, Falk, Mann, Matthias

“…Telomeres are actively transcribed into telomeric repeat-containing RNA (TERRA), which has been implicated in the regulation of telomere length and…”
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PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells by Viceconte, Nikenza, Loriot, Axelle, Lona Abreu, Patricia, Scheibe, Marion, Fradera Sola, Albert, Butter, Falk, De Smet, Charles, Azzalin, Claus Maria, Arnoult, Nausica, Decottignies, Anabelle

“…© 2021 Viceconte et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society. This article is distributed exclusively by the RNA Society for…”
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ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines by Dessilly, Géraldine, Elens, Laure, Panin, Nadtha, Capron, Arnaud, Decottignies, Anabelle, Demoulin, Jean-Baptiste, Haufroid, Vincent

“…ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-glycoprotein, is an efflux protein implicated in the absorption and the distribution of…”
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Highly Aggressive Metastatic Melanoma Cells Unable to Maintain Telomere Length by Viceconte, Nikenza, Dheur, Marie-Sophie, Majerova, Eva, Pierreux, Christophe E., Baurain, Jean-François, van Baren, Nicolas, Decottignies, Anabelle

“…Unlimited replicative potential is one of the hallmarks of cancer cells. In melanoma, hTERT (telomerase reverse transcriptase) is frequently overexpressed…”
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Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells by Tilman, Gaëlle, Mattiussi, Marina, Brasseur, Francis, van Baren, Nicolas, Decottignies, Anabelle

“…Recently, periostin (POSTN), a gene encoding a protein with similarity to the fasciclin family and involved in cell survival and angiogenesis, has emerged as a…”
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Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology by Suelves, Nuria, Saleki, Shirine, Ibrahim, Tasha, Palomares, Debora, Moonen, Sebastiaan, Koper, Marta J, Vrancx, Céline, Vadukul, Devkee M, Papadopoulos, Nicolas, Viceconte, Nikenza, Claude, Eloïse, Vandenberghe, Rik, von Arnim, Christine A F, Constantinescu, Stefan N, Thal, Dietmar Rudolf, Decottignies, Anabelle, Kienlen-Campard, Pascal

“…Aging is the main risk factor for Alzheimer's disease (AD) and other neurodegenerative pathologies, but the molecular and cellular changes underlying…”
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Assessment of senescence in adipose mesenchymal stem cells for optimized ex vivo expansion and therapeutic potential by Theys, Nicolas, Episkopou, Hara, Pierard, Céline, Decottignies, Anabelle

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Genome-wide mapping of nuclear mitochondrial DNA sequences links DNA replication origins to chromosomal double-strand break formation in Schizosaccharomyces pombe by Lenglez, Sandrine, Hermand, Damien, Decottignies, Anabelle

“…Chromosomal double-strand breaks (DSBs) threaten genome integrity and repair of these lesions is often mutagenic. How and where DSBs are formed is a major…”
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Specific death of ALT cells through TSPYL5 depletion by Claude, Eloïse, Episkopou, Harikleia, Decottignies, Anabelle

“…Some tumors acquire replicative immortality by activating an ALTernative telomerase-independent telomere maintenance mechanism. ALT offers interesting…”
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Human umbilical cord matrix stem cells maintain multilineage differentiation abilities and do not transform during long-term culture by Scheers, Isabelle, Lombard, Catherine, Paganelli, Massimiliano, Campard, David, Najimi, Mustapha, Gala, Jean-Luc, Decottignies, Anabelle, Sokal, Etienne

“…Umbilical cord matrix stem cells (UCMSC) have generated great interest in various therapeutic approaches, including liver regeneration. This article aims to…”
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TERRA and RAD51AP1 at the R&D-loop department of ALT telomeres by Decottignies, Anabelle

“…In this issue of Molecular Cell, Kaminski et al. and Yadav et al. demonstrate that RAD51AP1 and TERRA non-coding RNA positively regulate the alternative…”
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Detection of alternative lengthening of telomeres mechanism on tumor sections by Claude, Eloïse, de Lhoneux, Guillaume, Pierreux, Christophe E., Marbaix, Etienne, de Ville de Goyet, Maëlle, Boulanger, Cécile, Van Damme, An, Brichard, Bénédicte, Decottignies, Anabelle

“…The vast majority of adult cancer cells achieve cellular immortality by activating a telomere maintenance mechanism (TMM). While this is mostly achieved by the…”
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Complete inventory of the yeast ABC proteins by Decottignies, A. (Universite Catholique de Louvain, Louvain-la-Neuve, Belgium.), Goffeau, A

“…The complete sequence of the yeast genome predicts the existence of 29 proteins belonging to the ubiquitous ATP-binding cassette (ABC) superfamily. Using…”
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Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint by Yamaguchi, Satoko, Decottignies, Anabelle, Nurse, Paul

“…Cdc2p is a cyclin‐dependent kinase (CDK) essential for both mitotic and meiotic cell cycle progression in fission yeast. We have found that the spindle…”
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Adult-derived human liver progenitor cells in long-term culture maintain appropriate gatekeeper mechanisms against transformation by Scheers, Isabelle, Maerckx, Cedric, Khuu, Dung Ngoc, Marcelle, Sabrina, Decottignies, Anabelle, Najimi, Mustapha, Sokal, Etienne

“…The use of human liver progenitor cells in the development of clinical cell therapy depends on their constant availability and unaltered properties during…”
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Cancer-linked satellite 2 DNA hypomethylation does not regulate Sat2 non-coding RNA expression and is initiated by heat shock pathway activation by Tilman, Gaëlle, Arnoult, Nausica, Lenglez, Sandrine, Van Beneden, Amandine, Loriot, Axelle, De Smet, Charles, Decottignies, Anabelle

“…Epigenetic dysfunctions, including DNA methylation alterations, play major roles in cancer initiation and progression. Although it is well established that…”
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Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models by Benyelles, Maname, Episkopou, Harikleia, O'Donohue, Marie‐Françoise, Kermasson, Laëtitia, Frange, Pierre, Poulain, Florian, Burcu Belen, Fatma, Polat, Meltem, Bole‐Feysot, Christine, Langa‐Vives, Francina, Gleizes, Pierre‐Emmanuel, de Villartay, Jean‐Pierre, Callebaut, Isabelle, Decottignies, Anabelle, Revy, Patrick

“…PARN, poly(A)‐specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the h TR RNA component of telomerase. Biallelic…”
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