Search Results - "Decosterd, L."

High Cefepime Plasma Concentrations and Neurological Toxicity in Febrile Neutropenic Patients with Mild Impairment of Renal Function by LAMOTH, F, BUCLIN, T, PASCUAL, A, VORA, S, BOLAY, S, DECOSTERD, L. A, CALANDRA, T, MARCHETTI, O

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Therapeutic Drug Monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry by Haouala, A., Zanolari, B., Rochat, B., Montemurro, M., Zaman, K., Duchosal, M.A., Ris, H.B., Leyvraz, S., Widmer, N., Decosterd, L.A.

“…The treatment of some cancer patients has shifted from traditional, non-specific cytotoxic chemotherapy to chronic treatment with molecular targeted therapies…”
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Pharmacogenetics-Based Population Pharmacokinetic Analysis of Efavirenz in HIV-1-Infected Individuals by Arab‐Alameddine, M, Di Iulio, J, Buclin, T, Rotger, M, Lubomirov, R, Cavassini, M, Fayet, A, Décosterd, LA, Eap, CB, Biollaz, J, Telenti, A, Csajka, C

“…Besides CYP2B6, other polymorphic enzymes contribute to efavirenz (EFV) interindividual variability. This study was aimed at quantifying the impact of multiple…”
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Predictive Value of Known and Novel Alleles of CYP2B6 for Efavirenz Plasma Concentrations in HIV‐infected Individuals by Rotger, M, Tegude, H, Colombo, S, Cavassini, M, Furrer, H, Décosterd, L, Blievernicht, J, Saussele, T, Günthard, H F, Schwab, M, Eichelbaum, M, Telenti, A, Zanger, U M

“…To assess the association of CYP2B6 allelic diversity with efavirenz (EFV) pharmacokinetics, we performed extensive genotyping of 15 relevant single nucleotide…”
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Validation and clinical application of a multiplex high performance liquid chromatography – tandem mass spectrometry assay for the monitoring of plasma concentrations of 12 antibiotics in patients with severe bacterial infections by Decosterd, L.A., Mercier, T., Ternon, B., Cruchon, S., Guignard, N., Lahrichi, S., Pesse, B., Rochat, B., Burger, R., Lamoth, F., Pagani, J.-L., Eggimann, P., Csajka, C., Choong, E., Buclin, T., Widmer, N., André, P., Marchetti, O.

“…•Robust HPLC-MS/MS quantification of plasma levels of 12 daily-used antibiotics.•Directly covering the entire clinically relevant ranges of…”
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A single LC–tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma by Hodel, E.M., Zanolari, B., Mercier, T., Biollaz, J., Keiser, J., Olliaro, P., Genton, B., Decosterd, L.A.

“…Among the various determinants of treatment response, the achievement of sufficient blood levels is essential for curing malaria. For helping us at improving…”
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Clinical usefulness of therapeutic concentration monitoring for imatinib dosage individualization: results from a randomized controlled trial by Gotta, V., Widmer, N., Decosterd, L. A., Chalandon, Y., Heim, D., Gregor, M., Benz, R., Leoncini-Franscini, L., Baerlocher, G. M., Duchosal, M. A., Csajka, C., Buclin, T.

“…Purpose This study assessed whether a cycle of “routine” therapeutic drug monitoring (TDM) for imatinib dosage individualization, targeting an imatinib trough…”
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A LC–tandem MS assay for the simultaneous measurement of new antiretroviral agents: Raltegravir, maraviroc, darunavir, and etravirine by Fayet, A., Béguin, A., Zanolari, B., Cruchon, S., Guignard, N., Telenti, A., Cavassini, M., Günthard, H.F., Buclin, T., Biollaz, J., Rochat, B., Decosterd, L.A.

“…Raltegravir (RAL), maraviroc (MVC), darunavir (DRV), and etravirine (ETV) are new antiretroviral agents with significant potential for drug interactions. This…”
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Isavuconazole brain penetration in cerebral aspergillosis by Lamoth, F, Mercier, T, André, P, Pagani, J L, Pantet, O, Maduri, R, Guery, B, Decosterd, L A

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Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) methods for the therapeutic drug monitoring of cytotoxic anticancer drugs: An update by Briki, M., Murisier, A., Guidi, M., Seydoux, C., Buclin, T., Marzolini, C., Girardin, F.R., Thoma, Y., Carrara, S., Choong, E., Decosterd, L.A.

“…•Cytotoxic anticancer drugs are increasingly recognized to be valid candidates for therapeutic drug monitoring (TDM).•Numerous LC-MS/MS methods have been…”
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Stable HIV‐1 reservoirs on dolutegravir maintenance monotherapy: the MONODO study by Sculier, D, Doco‐Lecompte, T, Yerly, S, Metzner, KJ, Decosterd, LA, Calmy, A

“…Objectives Dolutegravir (DTG) is a highly effective integrase inhibitor with a strong genetic resistance barrier and a potential role in simplified HIV…”
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Intracellular measurements of anti-HIV drugs indinavir, amprenavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir, efavirenz and nevirapine in peripheral blood mononuclear cells by liquid chromatography coupled to tandem mass spectrometry by COLOMBO, S, BEGUIN, A, TELENTI, A, BIOLLAZ, J, BUCLIN, T, ROCHAT, B, DECOSTERD, L. A

“…A sensitive and accurate liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the intracellular determination of nine antiretroviral drugs in…”
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A battery of tandem mass spectrometry assays with stable isotope-dilution for the quantification of 15 anti-tuberculosis drugs and two metabolites in patients with susceptible-, multidrug-resistant- and extensively drug-resistant tuberculosis by Mercier, T., Desfontaine, V., Cruchon, S., Da Silva Pereira Clara, J.A., Briki, M., Mazza-Stalder, J., Kajkus, A., Burger, R., Suttels, V., Buclin, T., Opota, O., Koehler, N., Sanchez Carballo, P.M., Lange, C., André, P., Decosterd, L.A., Choong, E.

“…•Multiplex LC-MS/MS methods for major drugs against susceptible and MDR-tuberculosis.•Use of stable isotopically labelled Internal Standards for all…”
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A simple, robust and rapid approach to detect carbapenemases in Gram-negative isolates by MALDI-TOF mass spectrometry: validation with triple quadripole tandem mass spectrometry, microarray and PCR by Vogne, C., Prod'hom, G., Jaton, K., Decosterd, L.A., Greub, G.

“…Carbapenemases should be accurately and rapidly detected, given their possible epidemiological spread and their impact on treatment options. Here, we developed…”
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Population pharmacokinetics of imatinib and the role of α1‐acid glycoprotein by Widmer, N., Decosterd, L. A., Csajka, C., Leyvraz, S., Duchosal, M. A., Rosselet, A., Rochat, B., Eap, C. B., Henry, H., Biollaz, J., Buclin, T.

“…Aims The aims of this observational study were to assess the variability in imatinib pharmacokinetics and to explore the relationship between its disposition…”
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Relationship of imatinib-free plasma levels and target genotype with efficacy and tolerability by Widmer, N, Decosterd, L A, Leyvraz, S, Duchosal, M A, Rosselet, A, Debiec-Rychter, M, Csajka, C, Biollaz, J, Buclin, T

“…Imatinib has revolutionised the treatment of chronic myeloid leukaemia (CML) and gastrointestinal stromal tumours (GIST). Using a nonlinear mixed effects…”
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Antibiotic stability over six weeks in aqueous solution at body temperature with and without heat treatment that mimics the curing of bone cement by Samara, E, Moriarty, T F, Decosterd, L A, Richards, R G, Gautier, E, Wahl, P

“…Thermal stability is a key property in determining the suitability of an antibiotic agent for local application in the treatment of orthopaedic infections…”
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Population Pharmacokinetics of Ganciclovir in Solid-Organ Transplant Recipients Receiving Oral Valganciclovir by PERROTTET, N, CSAJKA, C, BIOLLAZ, J, BUCLIN, T, PASCUAL, M, MANUEL, O, LAMOTH, F, MEYLAN, P, AUBERT, J. D, VENETZ, J. P, SOCCAL, P, DECOSTERD, L. A

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An ultra performance liquid chromatography–tandem MS assay for tamoxifen metabolites profiling in plasma: First evidence of 4′-hydroxylated metabolites in breast cancer patients by Dahmane, E., Mercier, T., Zanolari, B., Cruchon, S., Guignard, N., Buclin, T., Leyvraz, S., Zaman, K., Csajka, C., Decosterd, L.A.

“…There is increasing evidence that the clinical efficacy of tamoxifen, the first and most widely used targeted therapy for estrogen-sensitive breast cancer,…”
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Imatinib plasma levels: correlation with clinical benefit in GIST patients by Widmer, N, Decosterd, L A, Csajka, C, Montemurro, M, Haouala, A, Leyvraz, S, Buclin, T

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