Search Results - "Decloedt, Eric"

Neuronal toxicity of efavirenz: a systematic review by Decloedt, Eric H, Maartens, Gary

“…Efavirenz commonly causes early neuropsychiatric side effects, but tolerance develops in most patients. There is emerging evidence that efavirenz use may…”
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Clinical Pharmacokinetics and Pharmacodynamics of Rifampicin in Human Tuberculosis by Abulfathi, Ahmed Aliyu, Decloedt, Eric H., Svensson, Elin M., Diacon, Andreas H., Donald, Peter, Reuter, Helmuth

“…The introduction of rifampicin (rifampin) into tuberculosis (TB) treatment five decades ago was critical for shortening the treatment duration for patients…”
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Chloroquine and Hydroxychloroquine for the Prevention or Treatment of COVID-19 in Africa: Caution for Inappropriate Off-label Use in Healthcare Settings by Abena, Pascale M, Decloedt, Eric H, Bottieau, Emmanuel, Suleman, Fatima, Adejumo, Prisca, Sam-Agudu, Nadia A, Muyembe TamFum, Jean-Jacques, Seydi, Moussa, Eholie, Serge P, Mills, Edward J, Kallay, Oscar, Zumla, Alimuddin, Nachega, Jean B

“…The novel severe acute respiratory syndrome-coronavirus-2 pandemic has spread to Africa, where nearly all countries have reported laboratory-confirmed cases of…”
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Central Nervous System Penetration of Antiretroviral Drugs: Pharmacokinetic, Pharmacodynamic and Pharmacogenomic Considerations by Decloedt, Eric H., Rosenkranz, Bernd, Maartens, Gary, Joska, John

“…The prevalence of HIV-associated neurocognitive disorder (HAND) is increasing despite the widespread use of combination antiretroviral therapy (ART). Initial…”
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How COVID-19 has fundamentally changed clinical research in global health by Park, Jay J H, Mogg, Robin, Smith, Gerald E, Nakimuli-Mpungu, Etheldreda, Jehan, Fyezah, Rayner, Craig R, Condo, Jeanine, Decloedt, Eric H, Nachega, Jean B, Reis, Gilmar, Mills, Edward J

“…COVID-19 has had negative repercussions on the entire global population. Despite there being a common goal that should have unified resources and efforts,…”
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The Ocular Penetration and Intraocular Pressure Lowering Effect of Topical Acetaminophen in the New Zealand White Rabbit by Anderson, Sean G, Meyer, David, Decloedt, Eric H

“…Emerging data suggest that acetaminophen lowers intraocular pressure (IOP) and has the potential to be repurposed as pharmacotherapy to treat open-angle…”
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Minimizing the impact of the triple burden of COVID-19, tuberculosis and HIV on health services in sub-Saharan Africa by Nachega, Jean B., Kapata, Nathan, Sam-Agudu, Nadia A., Decloedt, Eric H., Katoto, Patrick D.M.C., Nagu, Tumaini, Mwaba, Peter, Yeboah-Manu, Dorothy, Chanda-Kapata, Pascalina, Ntoumi, Francine, Geng, Elvin H., Zumla, Alimuddin

“…•Sub-Saharan Africa (SSA) bear a high proportion of the global burden of TB and HIV cases.•COVID-19 is negatively impacting on TB/HIV health services in…”
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Clozapine-Associated Leukopenia and Agranulocytosis in Western Cape, South Africa: A 3-Year Retrospective Cohort Study by Geldenhuys, Christoff, Zunza, Moleen, Tiffin, Nicki, Koen, Liezl, Decloedt, Eric H.

“…Clozapine may cause life-threatening hematological side effects (HSEs). Hematological side effect incidence data from Sub-Saharan Africa are lacking…”
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Single Dose Abacavir Pharmacokinetics and Safety in Neonates Exposed to Human Immunodeficiency Virus (HIV) by Bekker, Adrie, Decloedt, Eric H, Slade, Gretchen, Cotton, Mark F, Rabie, Helena, Cressey, Tim R

“…Abstract Abacavir is a potential option for prophylaxis and early treatment of human immunodeficiency virus (HIV), but no data are available in neonates. Ten…”
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The 12-month period prevalence and cardiac manifestations of HIV in patients with acute coronary syndrome at a tertiary hospital in Cape Town, South Africa: a retrospective cross-sectional study by Pennefather, Camilla, Esterhuizen, Tonya, Doubell, Anton, Decloedt, Eric H

“…Abstract Background HIV-positive patients are increasingly being affected by non-communicable diseases such as coronary artery disease (CAD). Data from…”
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Clinical characteristics associated with mortality of COVID-19 patients admitted to an intensive care unit of a tertiary hospital in South Africa by Nyasulu, Peter S, Ayele, Birhanu T, Koegelenberg, Coenraad F, Irusen, Elvis, Lalla, Usha, Davids, Razeen, Chothia, Yazied, Retief, Francois, Johnson, Marianne, Venter, Stephen, Pillay, Renilda, Prozesky, Hans, Taljaard, Jantjie, Parker, Arifa, Decloedt, Eric H, Jordan, Portia, Lahri, Sa'ad, Moosa, M Rafique, Moolla, Muhammad Saadiq, Yalew, Anteneh, Baines, Nicola, Maud, Padi, Louw, Elizabeth, Nortje, Andre, Dunbar, Rory, Sigwadhi, Lovemore N, Ngah, Veranyuy D, Tamuzi, Jacques L, Zemlin, Annalise, Chapanduka, Zivanai, English, René, Allwood, Brian W

“…Over 130 million people have been diagnosed with Coronavirus disease 2019 (COVID-19), and more than one million fatalities have been reported worldwide. South…”
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Prevalence and Characteristics of HIV-Associated Stroke in a Tertiary Hospital Setting in South Africa by Corbett, Craig, Brey, Naeem, Pitcher, Richard D., O'Hagan, Suzanne, Esterhuizen, Tonya M., Chow, Felicia C., Decloedt, Eric H.

“…BACKGROUND AND OBJECTIVESAntiretroviral treatment (ART) era HIV-associated stroke data from sub-Saharan Africa are limited. We determined the prevalence of HIV…”
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Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial by Cluver, Catherine A., Hannan, Natalie J., van Papendorp, Erika, Hiscock, Richard, Beard, Sally, Mol, Ben W., Theron, Gerhard B., Hall, David R., Decloedt, Eric H., Stander, Marietjie, Adams, Kim T., Rensburg, Megan, Schubert, Pawel, Walker, Susan P., Tong, Stephen

“…Preterm preeclampsia has a high rate of fetal death or disability. There is no treatment to slow the disease, except delivery. Preclinical studies have…”
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Pharmacogenetics of the Late-Onset Efavirenz Neurotoxicity Syndrome (LENS) by van Rensburg, Roland, Nightingale, Sam, Brey, Naeem, Albertyn, Christine H, Kellermann, Tracy A, Taljaard, Jantjie J, Esterhuizen, Tonya M, Sinxadi, Phumla Z, Decloedt, Eric H

“…Abstract Background The late-onset efavirenz neurotoxicity syndrome (LENS) presents as ataxia and/or encephalopathy with supratherapeutic efavirenz plasma…”
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A Retrospective Study Evaluating Neonatal Vancomycin Loading Doses to Achieve a Therapeutic Target by Fataar, Aaqilah, Pillay-Fuentes Lorente, Veshni, Decloedt, Eric H, van Eck, Andrew, Reddy, Kessendri, Dramowski, Angela, Bekker, Adrie

“…Vancomycin is a glycopeptide antibiotic that has been used to treat hospital-acquired gram-positive infections for more than 5 decades. However, the literature…”
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Evaluation of the Effectiveness of Dose Individualization to Achieve Therapeutic Vancomycin Concentrations by Abulfathi, Ahmed A., Chirehwa, Maxwell, Rosenkranz, Bernd, Decloedt, Eric H.

“…The glycopeptide antibiotic vancomycin is used for treatment of methicillin‐resistant Gram‐positive cocci. Adequate vancomycin plasma concentrations are…”
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Incident tuberculosis disease in patients receiving biologic therapies in the Western Cape, South Africa from 2007 to 2018 by du Toit, Tessa, Esterhuizen, Tonya M, Tiffin, Nicki, Abulfathi, Ahmed A, Reuter, Helmuth, Decloedt, Eric H

“…South Africa has one of the highest tuberculosis incidence rates. Biologic disease-modifying anti-rheumatic drugs are associated with an increased risk of…”
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Concentrations of Efavirenz, Tenofovir, and Emtricitabine in Obesity: A Cross-Sectional Study by Solanke, Toyosi, Kamau, Festus, Esterhuizen, Tonya, Maartens, Gary, Khoo, Saye, Joska, John A., Kellermann, Tracy, Strijdom, Hans, Decloedt, Eric H.

“…Background: Obesity is increasing worldwide including in people living with HIV (PLWH). Antiretroviral pharmacokinetic data in obesity are limited. Objectives:…”
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The safety, effectiveness and concentrations of adjusted lopinavir/ritonavir in HIV-infected adults on rifampicin-based antitubercular therapy by Decloedt, Eric H, Maartens, Gary, Smith, Peter, Merry, Concepta, Bango, Funeka, McIlleron, Helen

“…Rifampicin co-administration dramatically reduces plasma lopinavir concentrations. Studies in healthy volunteers and HIV-infected patients showed that doubling…”
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A preliminary review of warfarin toxicity in a tertiary hospital in Cape Town, South Africa by Decloedt, Eric H., Jacobs, Annemarie, Bassa, Fatima

“…Aim: Warfarin is a widely used anticoagulant for the prevention and treatment of thromboembolism. We conducted a retrospective review to determine the causes…”
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