Search Results - "Deckwerth, Thomas L."

A technology platform to assess multiple cancer agents simultaneously within a patient's tumor by Klinghoffer, Richard A, Bahrami, S Bahram, Hatton, Beryl A, Frazier, Jason P, Moreno-Gonzalez, Alicia, Strand, Andrew D, Kerwin, William S, Casalini, Joseph R, Thirstrup, Derek J, You, Sheng, Morris, Shelli M, Watts, Korashon L, Veiseh, Mandana, Grenley, Marc O, Tretyak, Ilona, Dey, Joyoti, Carleton, Michael, Beirne, Emily, Pedro, Kyle D, Ditzler, Sally H, Girard, Emily J, Deckwerth, Thomas L, Bertout, Jessica A, Meleo, Karri A, Filvaroff, Ellen H, Chopra, Rajesh, Press, Oliver W, Olson, James M

“…A fundamental problem in cancer drug development is that antitumor efficacy in preclinical cancer models does not translate faithfully to patient outcomes…”
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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer by Oost, Thorsten K, Sun, Chaohong, Armstrong, Robert C, Al-Assaad, Ali-Samer, Betz, Stephen F, Deckwerth, Thomas L, Ding, Hong, Elmore, Steven W, Meadows, Robert P, Olejniczak, Edward T, Oleksijew, Andrew, Oltersdorf, Tilman, Rosenberg, Saul H, Shoemaker, Alexander R, Tomaselli, Kevin J, Zou, Hua, Fesik, Stephen W

“…Inhibitor of apoptosis (IAP) proteins are overexpressed in many cancers and have been implicated in tumor growth, pathogenesis, and resistance to chemo- or…”
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BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development by Deckwerth, Thomas L, Elliott, Jeffrey L, Knudson, C.Michael, Johnson, Eugene M, Snider, William D, Korsmeyer, Stanley J

“…Members of the BCL2-related family of proteins either promote or repress programmed cell death. BAX, a death-promoting member, heterodimerizes with multiple…”
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A monobromobimane‐based assay to measure the pharmacokinetic profile of reactive sulphide species in blood by Wintner, Edward A, Deckwerth, Thomas L, Langston, William, Bengtsson, Asa, Leviten, Dina, Hill, Paul, Insko, Michael A, Dumpit, Ronald, VandenEkart, Emily, Toombs, Christopher F, Szabo, Csaba

“…Background and purpose:  Hydrogen sulphide (H2S) is a labile, endogenous metabolite of cysteine, with multiple biological roles. The development of…”
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Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition by Dey, Joyoti, Deckwerth, Thomas L., Kerwin, William S., Casalini, Joseph R., Merrell, Angela J., Grenley, Marc O., Burns, Connor, Ditzler, Sally H., Dixon, Chantel P., Beirne, Emily, Gillespie, Kate C., Kleinman, Edward F., Klinghoffer, Richard A.

“…Aberrant regulation of BCL-2 family members enables evasion of apoptosis and tumor resistance to chemotherapy. BCL-2 and functionally redundant counterpart,…”
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours by Fesik, Stephen W, Rosenberg, Saul H, Oltersdorf, Tilman, Elmore, Steven W, Shoemaker, Alexander R, Armstrong, Robert C, Augeri, David J, Belli, Barbara A, Bruncko, Milan, Deckwerth, Thomas L, Dinges, Jurgen, Hajduk, Philip J, Joseph, Mary K, Kitada, Shinichi, Korsmeyer, Stanley J, Kunzer, Aaron R, Letai, Anthony, Li, Chi, Mitten, Michael J, Nettesheim, David G, Ng, ShiChung, Nimmer, Paul M, O'Connor, Jacqueline M, Oleksijew, Anatol, Petros, Andrew M, Reed, John C, Shen, Wang, Tahir, Stephen K, Thompson, Craig B, Tomaselli, Kevin J, Wang, Baole, Wendt, Michael D, Zhang, Haichao

“…Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-XL and Bcl-2, are overexpressed…”
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Endoplasmic Reticulum Stress in PLP-Overexpressing Transgenic Rats: Gray Matter Oligodendrocytes Are More Vulnerable than White Matter Oligodendrocytes by BAUER, JAN, BRADL, MONIKA, KLEIN, MATTHIAS, LEISSER, MARIANNE, DECKWERTH, THOMAS L, WEKERLE, HARTMUT, LASSMANN, HANS

“…Studies dealing with transport of proteins from the oligodendrocyte cell body to the myelin sheath reveal the presence of different transport pathways…”
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Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide by Toombs, Christopher F., Insko, Michael A., Wintner, Edward A., Deckwerth, Thomas L., Usansky, Helen, Jamil, Khurram, Goldstein, Brahm, Cooreman, Michael, Szabo, Csaba

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Hydrogen sulphide (H2S) is a biological mediator and a potential therapeutic agent. In animal studies, the…”
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Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide by Insko, Michael A, Deckwerth, Thomas L, Hill, Paul, Toombs, Christopher F, Szabo, Csaba

“…Background and purpose:  Sodium sulphide (Na2S) disassociates to sodium (Na+) hydrosulphide, anion (HS‐) and hydrogen sulphide (H2S) in aqueous solutions. Here…”
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Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in rasmussen's encephalitis by Bien, Christian G., Bauer, Jan, Deckwerth, Thomas L., Wiendl, Heinz, Deckert, Martina, Wiestler, Otmar D., Schramm, Johannes, Elger, Christian E., Lassmann, Hans

“…Rasmussen's encephalitis is a progressive epileptic disorder characterized by unihemispheric lymphocytic infiltrates, microglial nodules, and neuronal loss…”
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Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease : Evidence for apoptotic cell death by STADELMANN, C, DECKWERTH, T. L, SRINIVASAN, A, BANCHER, C, BRÜCK, W, JELLINGER, K, LASSMANN, H

“…Neuronal loss is prominent in Alzheimer's disease (AD), and its mechanisms remain unresolved. Apoptotic cell death has been implicated on the basis of studies…”
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Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death by Greenlund, Laura J.S, Deckwerth, Thomas L, Johnson, Eugene M

“…Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor (NGF). We used this model of programmed cell death to study the mechanisms…”
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Temporal Analysis of Events Associated with Programmed Cell Death (Apoptosis) of Sympathetic Neurons Deprived of Nerve Growth Factor by Deckwerth, Thomas L., Johnson, Eugene M.

“…The time course of molecular events that accompany degeneration and death after nerve growth factor (NGF) deprivation and neuroprotection by NGF and other…”
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Analysis of the Mechanism of Loss of Trophic Factor Dependence Associated with Neuronal Maturation: A Phenotype Indistinguishable from Bax Deletion by Easton, Rachael M, Deckwerth, Thomas L, Parsadanian, Alexander Sh, Johnson, Eugene M., Jr

“…During development, sympathetic neurons are critically dependent on nerve growth factor (NGF) for survival. Neurons isolated from the superior cervical ganglia…”
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Neurites Can Remain Viable after Destruction of the Neuronal Soma by Programmed Cell Death (Apoptosis) by Deckwerth, Thomas L., Johnson, Eugene M.

“…During the development of the nervous system extensive programmed neuronal death occurs that is regulated by neurotrophic factors. Invariably, degeneration and…”
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Placement of the BCL2 Family Member BAX in the Death Pathway of Sympathetic Neurons Activated by Trophic Factor Deprivation by Deckwerth, Thomas L., Easton, Rachael M., Knudson, C.Michael, Korsmeyer, Stanley J., Johnson, Eugene M.

“…The BCL2 family member BAX is required for the induction of apoptosis in neonatal sympathetic neurons after NGF withdrawal.Bax-deficient sympathetic neurons…”
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Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke by Linton, Steven D., Aja, Teresa, Allegrini, Peter R., Deckwerth, Thomas L., Diaz, Jose-Luis, Hengerer, Bastian, Herrmann, Julia, Jahangiri, Kathy G., Kallen, Joerg, Karanewsky, Donald S., Meduna, Steven P., Nalley, Kip, Robinson, Edward D., Roggo, Silvio, Rovelli, Giorgio, Sauter, Andre, Sayers, Robert O., Schmitz, Albert, Smidt, Robert, Ternansky, Robert J., Tomaselli, Kevin J., Ullman, Brett R., Wiessner, Christoph, Wu, Joe C.

“…Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies…”
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Structure-activity relationships within a series of caspase inhibitors: Effect of leaving group modifications by ULLMAN, Brett R, AJA, Teresa, ROGGO, Silvio P, SAYERS, Robert O, SCHMITZ, Albert, TERNANSKY, Robert J, TOMASELLI, Kevin J, WU, Joe C, DECKWERTH, Thomas L, DIAZ, Jose-Luis, HERRMANN, Julia, KALISH, Vincent J, KARANEWSKY, Donald S, MEDUNA, Steven P, NALLEY, Kip, ROBINSON, Edward D

“…Various aryloxy methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A systematic study of their structure-activity relationship…”
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Neuronal death in developmental models: possible implications in neuropathology by Johnson, Jr, E M, Deckwerth, T L, Deshmukh, M

“…Extensive neuronal death occurs in the developing nervous system. Death of neurons during this process is apoptotic and appears to utilize a pathway that is…”
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Activation of Caspase-3 in Single Neurons and Autophagic Granules of Granulovacuolar Degeneration in Alzheimer's Disease by Stadelmann, Christine, Deckwerth, Thomas L., Srinivasan, Anu, Bancher, Christian, Brück, Wolfgang, Jellinger, Kurt, Lassmann, Hans

“…Neuronal loss is prominent in Alzheimer's disease (AD), and its mechanisms remain unresolved. Apoptotic cell death has been implicated on the basis of studies…”
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