Search Results - "Deckmyn, H."

An open conformation of ADAMTS‐13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura by Roose, E., Schelpe, A. S., Joly, B. S., Peetermans, M., Verhamme, P., Voorberg, J., Greinacher, A., Deckmyn, H., De Meyer, S. F., Coppo, P., Veyradier, A., Vanhoorelbeke, K.

“…Essentials Conformational changes in ADAMTS‐13 are part of its mode‐of‐action. The murine anti‐ADAMTS‐13 antibody 1C4 discriminates between folded and open…”
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Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS‐13 by Deforche, L., Roose, E., Vandenbulcke, A., Vandeputte, N., Feys, H. B., Springer, T. A., Mi, L. Z., Muia, J., Sadler, J. E., Soejima, K., Rottensteiner, H., Deckmyn, H., De Meyer, S. F., Vanhoorelbeke, K.

“…Summary Background Recently, conformational activation of ADAMTS‐13 was identified. This mechanism showed the evolution from a condensed conformation, in which…”
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High and long‐term von Willebrand factor expression after Sleeping Beauty transposon‐mediated gene therapy in a mouse model of severe von Willebrand disease by Portier, I., Vanhoorelbeke, K., Verhenne, S., Pareyn, I., Vandeputte, N., Deckmyn, H., Goldenberg, D. S., Samal, H. B., Singh, M., Ivics, Z., Izsvák, Z., De Meyer, S. F.

“…Essentials von Willebrand disease (VWD) is the most common inherited bleeding disorder. Gene therapy for VWD offers long‐term therapy for VWD patients…”
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Amplified endogenous plasmin activity resolves acute thrombotic thrombocytopenic purpura in mice by Tersteeg, C., Joly, B. S., Gils, A., Lijnen, R., Deckmyn, H., Declerck, P. J., Plaimauer, B., Coppo, P., Veyradier, A., Maas, C., De Meyer, S. F., Vanhoorelbeke, K.

“…Essentials Plasmin is able to proteolyse von Willebrand factor. It was unclear if plasmin influences acute thrombotic thrombocytopenic purpura (TTP). Plasmin…”
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The hemostatic system by Stassen, J M, Arnout, J, Deckmyn, H

“…The hemostatic system comprises platelet aggregation, coagulation and fibrinolysis also termed primary, secondary and tertiary hemostasis. From the platelet…”
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The novel ADAMTS13‐p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice by De Cock, E., Hermans, C., De Raeymaecker, J., De Ceunynck, K., De Maeyer, B., Vandeputte, N., Vandenbulcke, A., Deckmyn, H., Rottensteiner, H., De Maeyer, M., De Meyer, S. F., Vanhoorelbeke, K.

“…Summary Background Congenital thrombotic thrombocytopenic purpura (TTP) is characterized by mutations in the ADAMTS13 gene, which either impair protein…”
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Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors by Vermeersch, E., Liénart, S., Collignon, A., Lucas, S., Gallimore, A., Gysemans, C., Unutmaz, D., Vanhoorelbeke, K., De Meyer, S.F., Maes, W., Deckmyn, H.

“…•To investigate immunosuppressive properties of GARP on Treg in experimental tumors.•Treg specific garp KO mice were successfully generated.•KO mice with…”
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Multiple ways to switch platelet integrins on and off by COSEMANS, J. M. E. M., ISERBYT, B. F., DECKMYN, H., HEEMSKERK, J. W. M.

“…In the classical concept of platelet integrin activation, it is considered that unidirectional conformational changes of αIIbβ3 and α2β1 regulate the…”
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Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura by FEYS, H. B., VANDEPUTTE, N., PALLA, R., PEYVANDI, F., PEERLINCK, K., DECKMYN, H., LIJNEN, H. R., VANHOORELBEKE, K.

“…Background: ADAMTS13 deficiency causes accumulation of unusually large von Willebrand factor molecules, which cross‐link platelets in the circulation or on the…”
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Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding by Swieringa, F., Lancé, M. D., Fuchs, B., Feijge, M. A. H., Solecka, B. A., Verheijen, L. P. J., Hughes, K. R., Oerle, R., Deckmyn, H., Kannicht, C., Heemskerk, J. W. M., Meijden, P. E. J.

“…Summary Background Patients undergoing major cardiothoracic surgery are subjected to dilution, owing to massive fluid infusion and blood component transfusion…”
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In vivo von Willebrand factor size heterogeneity in spite of the clinical deficiency of ADAMTS‐13 by DE MEYER, S. F., BUDDE, U., DECKMYN, H., VANHOORELBEKE, K.

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The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet‐decorated VWF strings in vivo by DE MAEYER, B., DE MEYER, S. F., FEYS, H. B., PAREYN, I., VANDEPUTTE, N., DECKMYN, H., VANHOORELBEKE, K.

“…Background: The multidomain metalloprotease ADAMTS13 regulates the size of von Willebrand factor (VWF) multimers upon their release from endothelial cells. How…”
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ADAMTS‐13 plasma level determination uncovers antigen absence in acquired thrombotic thrombocytopenic purpura and ethnic differences by FEYS, H. B., LIU, F., DONG, N., PAREYN, I., VAUTERIN, S., VANDEPUTTE, N., NOPPE, W., RUAN, C., DECKMYN, H., VANHOORELBEKE, K.

“…Background: The recently discovered plasma enzyme ADAMTS‐13 cleaves the A2‐domain of von Willebrand factor (VWF). A defective cleaving protease results in…”
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Macroporous monolithic gels, cryogels, with immobilized phages from phage-display library as a new platform for fast development of affinity adsorbent capable of target capture from crude feeds by Noppe, Wim, Plieva, Fatima M., Vanhoorelbeke, Karen, Deckmyn, Hans, Tuncel, Mürvet, Tuncel, Ali, Galaev, Igor Yu, Mattiasson, Bo

“…Selected phage clones expressing a peptide with high binding affinity for recombinant human lactoferrin or von Willebrand factor (vWF) were covalently coupled…”
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Blockade of Glycoproteins Ib and IIb/IIIa Reduces Platelet Sequestration and PVR Rise in a Xenogeneic Lung Perfusion Model by Burdorf, L, Riner, A, Rybak, E, Harris, D, Dahi, S, Zhang, T, Parsell, D, Ali, F, Schwartz, E, Kang, E, Cheng, X, Sievert, E, Braileanu, G, Quinn, K, Shah, A, De Meyer, S, Deckmyn, H, Phelps, C.J, Ayares, D.L, Pierson, R.N, Azimzadeh, A.M

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295 Combined aGPIb and aGPIIb/IIIa Blockade Prevents Platelet Sequestration in a Pig-to-Human Lung Perfusion Model by Burdorf, L, Zhang, T, Rybak, E, Salles, I.I, Broos, K, Welty, E, Avon, C, Laaris, A, Cheng, X, Ayares, D, Deckmyn, H, Azimzadeh, A.M, Pierson, R.N

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Identification of a VWF peptide antagonist that blocks platelet adhesion under high shear conditions by selectively inhibiting the VWF‐collagen interaction by SZANTO, T., VANHOORELBEKE, K., TOTH, G., VANDENBULCKE, A., TOTH, J., NOPPE, W., DECKMYN, H., HARSFALVI, J.

“…Background: Because the collagen‐VWF‐GPIb/IX/V axis plays an important role in thrombus formation, it represents a promising target for development of new…”
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The von Willebrand factor self‐association is modulated by a multiple domain interaction by ULRICHTS, H., VANHOORELBEKE, K., GIRMA, J. P., LENTING, P. J., VAUTERIN, S., DECKMYN, H.

“…Background: Platelet adhesion and aggregation at sites of vascular injury exposed to rapid blood flow require von Willebrand factor (VWF). VWF becomes…”
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295 Blocking GP1b-vWF Interaction by Anti-GP1b Fab Reduces Activation and Sequestration of Platelets in a Xenogeneic Pig Lung Perfusion Model by Burdorf, L, Zhang, T, Rybak, E, Salles, I.I, Broos, K, Welty, E, Avon, C, Laaris, A, Cheng, X, Ayares, D, Deckmyn, H, Azimzadeh, A.M, Pierson, R.N

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ADAMTS‐13 plasma level determination uncovers antigen absence in acquired thrombotic thrombocytopenic purpura and ethnic differences by FEYS, H.B., LIU, F., DONG, N., PAREYN, I., VAUTERIN, S., VANDEPUTTE, N., NOPPE, W., RUAN, C., DECKMYN, H., VANHOORELBEKE, K.

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