Search Results - "Decker, Patrice"

Extracellular Chromatin Triggers Release of Soluble CEACAM8 Upon Activation of Neutrophils by Ribon, Matthieu, Mussard, Julie, Semerano, Luca, Singer, Bernhard B, Decker, Patrice

“…Increased concentrations of extracellular chromatin are observed in cancer, sepsis, and inflammatory autoimmune diseases like systemic lupus erythematosus…”
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Involvement of Tumor Necrosis Factor Receptor Type II in FoxP3 Stability and as a Marker of Treg Cells Specifically Expanded by Anti–Tumor Necrosis Factor Treatments in Rheumatoid Arthritis by Santinon, François, Batignes, Maxime, Mebrek, Majda Lyna, Biton, Jerôme, Clavel, Gaëlle, Hervé, Roxane, Lemeiter, Delphine, Breckler, Magali, Busato, Florence, Tost, Jorg, Ziol, Marianne, Boissier, Marie‐Christophe, Decker, Patrice, Semerano, Luca, Bessis, Natacha

“…Objective To study the involvement of Treg cells expressing tumor necrosis factor receptor type II (TNFRII) in exerting control of inflammation in experimental…”
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In Vivo Expansion of Activated Foxp3+ Regulatory T Cells and Establishment of a Type 2 Immune Response upon IL-33 Treatment Protect against Experimental Arthritis by Biton, Jérôme, Khaleghparast Athari, Sara, Thiolat, Allan, Santinon, François, Lemeiter, Delphine, Hervé, Roxane, Delavallée, Laure, Levescot, Anais, Roga, Stéphane, Decker, Patrice, Girard, Jean-Philippe, Herbelin, André, Boissier, Marie-Christophe, Bessis, Natacha

“…IL-33 is strongly involved in several inflammatory and autoimmune disorders with both pro- and anti-inflammatory properties. However, its contribution to…”
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Neutrophil extracellular traps (NET): not only antimicrobial but also modulators of innate and adaptive immunities in inflammatory autoimmune diseases by Melbouci, Dyhia, Haidar Ahmad, Ahmad, Decker, Patrice

“…Polymorphonuclear neutrophils (PMN) represent one of the first lines of defence against invading pathogens and are the most abundant leucocytes in the…”
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Nuclease A (Gbs0661), an extracellular nuclease of Streptococcus agalactiae, attacks the neutrophil extracellular traps and is needed for full virulence by Derré‐Bobillot, Aurélie, Cortes‐Perez, Naima G., Yamamoto, Yuji, Kharrat, Pascale, Couvé, Elizabeth, Da Cunha, Violette, Decker, Patrice, Boissier, Marie‐Christophe, Escartin, Frédéric, Cesselin, Bénédicte, Langella, Philippe, Bermúdez‐Humarán, Luis G., Gaudu, Philippe

“…Summary Most bacteria of the genus Streptococcus are opportunistic pathogens, and some of them produce extracellular DNases, which may be important for…”
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Deoxyribonuclease 1-Mediated Clearance of Circulating Chromatin Prevents From Immune Cell Activation and Pro-inflammatory Cytokine Production, a Phenomenon Amplified by Low Trap1 Activity: Consequences for Systemic Lupus Erythematosus by Felux, Jasmin, Erbacher, Annika, Breckler, Magali, Hervé, Roxane, Lemeiter, Delphine, Mannherz, Hans Georg, Napirei, Markus, Rammensee, Hans-Georg, Decker, Patrice

“…Increased concentrations of circulating chromatin, especially oligo-nucleosomes, are observed in sepsis, cancer and some inflammatory autoimmune diseases like…”
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The mouse dendritic cell marker CD11c is down-regulated upon cell activation through Toll-like receptor triggering by Singh-Jasuja, Harpreet, Thiolat, Allan, Ribon, Matthieu, Boissier, Marie-Christophe, Bessis, Natacha, Rammensee, Hans-Georg, Decker, Patrice

“…Abstract Dendritic cells (DC) play a key role in regulating immune responses and are the best professional antigen-presenting cells. Two major DC populations…”
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Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus by Hervier, Baptiste, Ribon, Matthieu, Tarantino, Nadine, Mussard, Julie, Breckler, Magali, Vieillard, Vincent, Amoura, Zahir, Steinle, Alexander, Klein, Reinhild, Kötter, Ina, Decker, Patrice

“…Systemic lupus erythematosus (SLE) is a severe autoimmune disease of unknown etiology. The major histocompatibility complex (MHC) class I-related chain A…”
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Polymorphonuclear Neutrophils in Rheumatoid Arthritis and Systemic Lupus Erythematosus: More Complicated Than Anticipated by Haidar Ahmad, Ahmad, Melbouci, Dyhia, Decker, Patrice

“…Polymorphonuclear neutrophils (PMN) are the most abundant leucocytes in the circulation in humans. They represent a heterogeneous population exerting diverse…”
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Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress by Decker, Patrice, Muller, Sylviane

“…Poly (ADP-ribose) polymerase is a zinc-finger DNA-binding enzyme which detects and signals DNA strand breaks generated either directly during base excision…”
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Primary blood neutrophils express a functional cell surface Toll‐like receptor 9 by Lindau, Dennis, Mussard, Julie, Wagner, Britta J., Ribon, Matthieu, Rönnefarth, Viktoria M., Quettier, Maude, Jelcic, Ivan, Boissier, Marie‐Christophe, Rammensee, Hans‐Georg, Decker, Patrice

“…Polymorphonuclear leukocytes (PMNs) represent one of the first lines of defense against pathogens. TLR9 is normally expressed in endosomes/lysosomes where it…”
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PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase by Amé, J C, Rolli, V, Schreiber, V, Niedergang, C, Apiou, F, Decker, P, Muller, S, Höger, T, Ménissier-de Murcia, J, de Murcia, G

“…Poly(ADP-ribosylation) is a post-translational modification of nuclear proteins in response to DNA damage that activates the base excision repair machinery…”
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Nucleosome-induced neutrophil activation occurs independently of TLR9 and endosomal acidification: Implications for systemic lupus erythematosus by Lindau, Dennis, Rönnefarth, Viktoria, Erbacher, Annika, Rammensee, Hans-Georg, Decker, Patrice

“…The nucleosome is a major autoantigen known to activate PMN in systemic lupus erythematosus (SLE). TLR9 recognizes bacterial and even mammalian DNA under…”
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Tumor Necrosis Factor-Alpha Targeting Can Protect against Arthritis with Low Sensitization to Infection by Belmellat, Nadia, Semerano, Luca, Segueni, Noria, Damotte, Diane, Decker, Patrice, Ryffel, Bernhard, Quesniaux, Valérie, Boissier, Marie-Christophe, Assier, Eric

“…Tumor necrosis factor-alpha (TNF-α) blockade is an effective treatment for rheumatoid arthritis (RA) and other inflammatory diseases, but in patients, it is…”
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Nucleosome, the Main Autoantigen in Systemic Lupus Erythematosus, Induces Direct Dendritic Cell Activation via a MyD88-Independent Pathway: Consequences on Inflammation by Decker, Patrice, Singh-Jasuja, Harpreet, Haager, Sabine, Kotter, Ina, Rammensee, Hans-Georg

“…Nucleosome is the major autoantigen in systemic lupus erythematosus. It is found as a circulating complex in the sera of patients and seems to play a key role…”
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Inhibition of Caspase-3-mediated Poly(ADP-ribose) Polymerase (PARP) Apoptotic Cleavage by Human PARP Autoantibodies and Effect on Cells Undergoing Apoptosis by Decker, Patrice, Isenberg, David, Muller, Sylviane

“…Autoantibodies directed to nuclear antigens are serological hallmarks of autoimmune rheumatic diseases such as systemic lupus erythematosus. Although much more…”
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TLR2/TLR4-Independent Neutrophil Activation and Recruitment upon Endocytosis of Nucleosomes Reveals a New Pathway of Innate Immunity in Systemic Lupus Erythematosus by Ronnefarth, Viktoria M, Erbacher, Annika I. M, Lamkemeyer, Tobias, Madlung, Johannes, Nordheim, Alfred, Rammensee, Hans-Georg, Decker, Patrice

“…The nucleosome is a major autoantigen in systemic lupus erythematosus (SLE); it can be detected as a circulating complex in the serum, and nucleosomes have…”
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Neutrophils and interferon-α-producing cells: who produces interferon in lupus? by Decker, Patrice

“…Interferon-α plays a crucial role in the pathogenesis of systemic lupus erythematosus. Nevertheless, the different human cell types producing this cytokine as…”
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Expression of iron transport proteins divalent metal transporter-1, Ferroportin-1, HFE and transferrin receptor-1 in human monocyte-derived dendritic cells by Brinkmann, Martin, Teuffel, Regina, Laham, Nihay, Ehrlich, Rachel, Decker, Patrice, Lemonnier, Francois A., Pascolo, Steve

“…Iron is essential for cell survival and regulates many cell functions. In the context of the immune response, iron‐related metabolism is tightly controlled in…”
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Arthritis models: usefulness and interpretation by Bessis, Natacha, Decker, Patrice, Assier, Eric, Semerano, Luca, Boissier, Marie-Christophe

“…Animal models of arthritis are used to better understand pathophysiology of a disease or to seek potential therapeutic targets or strategies. Focusing on…”
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