Search Results - "Decker, Keith F."

Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions by Decker, Keith F, Zheng, Dali, He, Yuhong, Bowman, Tamara, Edwards, John R, Jia, Li

“…The androgen receptor (AR) is a ligand-inducible transcription factor that mediates androgen action in target tissues. Upon ligand binding, the AR binds to…”
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Androgen receptor‐regulated miRNA‐193a‐3p targets AJUBA to promote prostate cancer cell migration by Jia, Li, Gui, Bin, Zheng, Dali, Decker, Keith F., Tinay, Ilker, Tan, Mingyue, Wang, Xiaowei, Kibel, Adam S.

“…Background Dysregulation of microRNA (miRNA) expression is implicated in cancer development and progression by modulating oncogenes or tumor suppressors at the…”
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Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium by Decker, Keith F, Heijman, Jordi, Silva, Jonathan R, Hund, Thomas J, Rudy, Yoram

“…Computational models of cardiac myocytes are important tools for understanding ionic mechanisms of arrhythmia. This work presents a new model of the canine…”
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Role of WNT7B-induced noncanonical pathway in advanced prostate cancer by Zheng, Dali, Decker, Keith F, Zhou, Tianhua, Chen, Jianquan, Qi, Zongtai, Jacobs, Kathryn, Weilbaecher, Katherine N, Corey, Eva, Long, Fanxin, Jia, Li

“…Advanced prostate cancer is characterized by incurable castration-resistant progression and osteoblastic bone metastasis. While androgen deprivation therapy…”
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multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential by Silva, Jonathan R, Pan, Hua, Wu, Dick, Nekouzadeh, Ali, Decker, Keith F, Cui, Jianmin, Baker, Nathan A, Sept, David, Rudy, Yoram

“…Ion-channel function is determined by its gating movement. Yet, molecular dynamics and electrophysiological simulations were never combined to link molecular…”
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Ionic bases for electrical remodeling of the canine cardiac ventricle by Jeyaraj, Darwin, Wan, Xiaoping, Ficker, Eckhard, Stelzer, Julian E, Deschenes, Isabelle, Liu, Haiyan, Wilson, Lance D, Decker, Keith F, Said, Tamer H, Jain, Mukesh K, Rudy, Yoram, Rosenbaum, David S

“…Emerging evidence suggests that ventricular electrical remodeling (VER) is triggered by regional myocardial strain via mechanoelectrical feedback mechanisms;…”
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Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes by Vanderkraats, Nathan D, Hiken, Jeffrey F, Decker, Keith F, Edwards, John R

“…Methylation of the CpG-rich region (CpG island) overlapping a gene's promoter is a generally accepted mechanism for silencing expression. While recent…”
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Ionic mechanisms of electrophysiological heterogeneity and conduction block in the infarct border zone by Decker, Keith F, Rudy, Yoram

“…The increased incidence of arrhythmia in the healing phase after infarction has been linked to remodeling in the epicardial border zone (EBZ). Ionic models of…”
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p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer by Powell, Emily, Shao, Jiansu, Yuan, Yuan, Chen, Hsiang-Chun, Cai, Shirong, Echeverria, Gloria V, Mistry, Nipun, Decker, Keith F, Schlosberg, Christopher, Do, Kim-Anh, Edwards, John R, Liang, Han, Piwnica-Worms, David, Piwnica-Worms, Helen

“…Despite advances in early diagnosis and treatment of cancer patients, metastasis remains the major cause of mortality. TP53 is one of the most frequently…”
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Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling by Hund, Thomas J, Decker, Keith F, Kanter, Evelyn, Mohler, Peter J, Boyden, Penelope A, Schuessler, Richard B, Yamada, Kathryn A, Rudy, Yoram

“…Abstract Ca2+ /calmodulin-dependent protein kinase II is a multifunctional serine/threonine kinase with diverse cardiac roles including regulation of…”
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A Nucleus-targeted Alternately Spliced Nix/Bnip3L Protein Isoform Modifies Nuclear Factor κB (NFκB)-mediated Cardiac Transcription by Chen, Yun, Decker, Keith F., Zheng, Dali, Matkovich, Scot J., Jia, Li, Dorn, Gerald W.

“…Several Bcl2 family proteins are expressed both as mitochondrial-targeted full-length and as cytosolic truncated alternately spliced isoforms. Recombinantly…”
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Abstract A6: Androgen receptor-mediated transcription is reprogrammed after hormone depletion by Decker, Keith F., Zheng, Dali, Edwards, John R., Jia, Li

“…Androgen receptor (AR) is a ligand-induced transcription factor, which binds to thousands of genomic loci and activates a cell-type specific gene expression…”
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Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer by Hiken, J F, McDonald, J I, Decker, K F, Sanchez, C, Hoog, J, VanderKraats, N D, Jung, K L, Akinhanmi, M, Rois, L E, Ellis, M J, Edwards, J R

“…Approximately 75% of breast cancers express estrogen receptor α (ERα) and depend on estrogen signals for continued growth. Aromatase inhibitors (AIs) prevent…”
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Abstract LB-300: The role of WNT7B in prostate cancer bone metastasis by Zheng, Dali, Zhou, Tianhua, Decker, Keith F., Wang, Kaidi, Jia, Li

“…Prostate cancer is the most common cancer for men in the US. It is well known that the androgen receptor (AR), a master transcription factor in prostate, plays…”
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p53 deficiency linked to B cell translocation gene 2 models of triple-negative breast cancer by Powell, Emily, Shao, Jiansu, Yuan, Yuan, Chen, Hsiang-Chun, Cai, Shirong, Echeverria, Gloria V, Mistry, Nipun, Decker, Keith F, Schlosberg, Christopher, Do, Kim-Anh, Edwards, John R, Liang, Han, Piwnica-Worms, David, Piwnica-Worms, Helen

“…Background Despite advances in early diagnosis and treatment of cancer patients, metastasis remains the major cause of mortality. TP53 is one of the most…”
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Role of activated CaMKII in abnormal calcium homeostasis and I(Na) remodeling after myocardial infarction: insights from mathematical modeling by Hund, Thomas J, Decker, Keith F, Kanter, Evelyn, Mohler, Peter J, Boyden, Penelope A, Schuessler, Richard B, Yamada, Kathryn A, Rudy, Yoram

“…Ca(2+)/calmodulin-dependent protein kinase II is a multifunctional serine/threonine kinase with diverse cardiac roles including regulation of excitation…”
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