Search Results - "Decker, Helena"

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers by De Felice, Fernanda G, Vieira, Marcelo N.N, Bomfim, Theresa R, Decker, Helena, Velasco, Pauline T, Lambert, Mary P, Viola, Kirsten L, Zhao, Wei-Qin, Ferreira, Sergio T, Klein, William L

“…Synapse deterioration underlying severe memory loss in early Alzheimer's disease (AD) is thought to be caused by soluble amyloid beta (Aβ) oligomers…”
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Aqueous CuS nanocrystals via a flow synthesis approach by Decker, Helena, Wolf, Andre, Kemmler, Moritz, Lesnyak, Vladimir

“…Aqueous synthesis of covellite CuS nanoparticles holds significant importance in the field of nanomaterials and environmental sustainability. Using water as a…”
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Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT by Fang, Cheng, Decker, Helena, Banker, Gary

“…Abstract Deficits in axonal transport are thought to contribute to the pathology of many neurodegenerative diseases. Expressing the slow Wallerian degeneration…”
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Thyroid hormone increases astrocytic glutamate uptake and protects astrocytes and neurons against glutamate toxicity by Mendes-de-Aguiar, Cláudia Beatriz Nedel, Alchini, Ricardo, Decker, Helena, Alvarez-Silva, Marcio, Tasca, Carla Inês, Trentin, Andréa Gonçalves

“…Thyroid hormone (T3) regulates the growth and differentiation of rat cerebellar astrocytes. Previously, we have demonstrated that these effects are due, at…”
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A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations by Bentley, Marvin, Decker, Helena, Luisi, Julie, Banker, Gary

“…Identifying the proteins that regulate vesicle trafficking is a fundamental problem in cell biology. In this paper, we introduce a new assay that involves the…”
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Amyloid-β Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3β in Primary Cultured Hippocampal Neurons by Decker, Helena, Lo, Karen Y., Unger, Sandra M., Ferreira, Sergio T., Silverman, Michael A.

“…Disruption of axonal transport is a hallmark of several neurodegenerative diseases, including Alzheimer's disease (AD). Even though defective transport is…”
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A novel split kinesin assay identifies motor proteins that interact with distinct vesicle populations by Jenkins, Brian, Decker, Helena, Bentley, Marvin, Luisi, Julie, Banker, Gary

“…Identifying the kinesin motors that interact with different vesicle populations is a longstanding and challenging problem with implications for many aspects of…”
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Emulsion-templated flexible epoxy foams by Steindl, Patrick, Decker, Helena, Retzl, Bernhard, Jiang, Qixiang, Menner, Angelika, Bismarck, Alexander

“…Flexible epoxy foams were successfully prepared by curing medium internal phase emulsions (MIPEs) with a continuous organic phase containing epoxy resin and…”
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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers by Bomfim, Theresa R, Forny-Germano, Leticia, Sathler, Luciana B, Brito-Moreira, Jordano, Houzel, Jean-Christophe, Decker, Helena, Silverman, Michael A, Kazi, Hala, Melo, Helen M, McClean, Paula L, Holscher, Christian, Arnold, Steven E, Talbot, Konrad, Klein, William L, Munoz, Douglas P, Ferreira, Sergio T, De Felice, Fernanda G

“…Defective brain insulin signaling has been suggested to contribute to the cognitive deficits in patients with Alzheimer's disease (AD). Although a connection…”
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Simultaneous Ligand and Cation Exchange of Colloidal CdSe Nanoplatelets toward PbSe Nanoplatelets for Application in Photodetectors by Galle, Tom, Spittel, Daniel, Weiß, Nelli, Shamraienko, Volodymyr, Decker, Helena, Georgi, Maximilian, Hübner, René, Metzkow, Nadia, Steinbach, Christine, Schwarz, Dana, Lesnyak, Vladimir, Eychmüller, Alexander

“…Cation exchange emerged as a versatile tool to obtain a variety of nanocrystals not yet available via a direct synthesis. Reduced reaction times and moderate…”
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Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors by Tu, Xun, Jain, Anant, Parra Bueno, Paula, Decker, Helena, Liu, Xiaodan, Yasuda, Ryohei

“…The insulin superfamily of peptides is essential for homeostasis as well as neuronal plasticity, learning, and memory. Here, we show that insulin-like growth…”
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N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers by Decker, Helena, Jürgensen, Sofia, Adrover, Martin F, Brito-Moreira, Jordano, Bomfim, Theresa R, Klein, William L, Epstein, Alberto L, De Felice, Fernanda G, Jerusalinsky, Diana, Ferreira, Sergio T

“…J. Neurochem. (2010) 115, 1520-1529. ABSTRACT: Soluble amyloid-β peptide (Aβ) oligomers, known to accumulate in Alzheimer's disease brains, target excitatory…”
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Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons by Ramser, Elisa M, Gan, Kathlyn J, Decker, Helena, Fan, Emily Y, Suzuki, Matthew M, Ferreira, Sergio T, Silverman, Michael A

“…Disruption of fast axonal transport (FAT) is an early pathological event in Alzheimer's disease (AD). Soluble amyloid-β oligomers (AβOs), increasingly…”
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The Clathrin Adaptor Complex Responsible for Somatodendritic Protein Sorting by Bentley, Marvin, Decker, Helena, Banker, Gary

“…Neuronal proteins contain “address labels” that govern their localization. In this issue of Neuron, Farías et al. (2012) identify the machinery that recognizes…”
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Guanosine and GMP increase the number of granular cerebellar neurons in culture: dependence on adenosine A2A and ionotropic glutamate receptors by Decker, Helena, Piermartiri, Tetsade C. B., Nedel, Cláudia B., Romão, Luciana F., Francisco, Sheila S., Dal-Cim, Tharine, Boeck, Carina R., Moura-Neto, Vivaldo, Tasca, Carla I.

“…The guanine-based purines (GBPs) have essential extracellular functions such as modulation of glutamatergic transmission and trophic effects on neurons and…”
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Guanosine and GMP increase the number of granular cerebellar neurons in culture: dependence on adenosine A 2A and ionotropic glutamate receptors by Decker, Helena, Piermartiri, Tetsade C B, Nedel, Cláudia B, Romão, Luciana F, Francisco, Sheila S, Dal-Cim, Tharine, Boeck, Carina R, Moura-Neto, Vivaldo, Tasca, Carla I

“…The guanine-based purines (GBPs) have essential extracellular functions such as modulation of glutamatergic transmission and trophic effects on neurons and…”
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GMP prevents excitotoxicity mediated by NMDA receptor activation but not by reversal activity of glutamate transporters in rat hippocampal slices by Molz, Simone, Tharine, Dal-Cim, Decker, Helena, Tasca, Carla I

“…Abstract Glutamate is the main excitatory neurotransmitter in the mammalian nervous system and is essential for its normal functions. However, overstimulation…”
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N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-[beta] peptide oligomers by Decker, Helena, Jürgensen, Sofia, Adrover, Martin F, Brito-Moreira, Jordano, Bomfim, Theresa R, Klein, William L, Epstein, Alberto L, De Felice, Fernanda G, Jerusalinsky, Diana, Ferreira, Sergio T

“…Soluble amyloid-β peptide (Aβ) oligomers, known to accumulate in Alzheimer's disease brains, target excitatory post-synaptic terminals. This is thought to…”
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Impaired astrocytic extracellular matrix distribution under congenital hypothyroidism affects neuronal development in vitro by Mendes-de-Aguiar, Cláudia Beatriz Nedel, Alchini, Ricardo, Zucco, Juliana Klein, Costa-Silva, Bruno, Decker, Helena, Alvarez-Silva, Marcio, Tasca, Carla Inês, Trentin, Andréa Gonçalves

“…Astrocytes clearly play a role in neuronal development. An indirect mechanism of thyroid hormone (T3) in the regulation of neuronal development mediated by…”
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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated A[Beta] oligomers by Bomfim, Theresa R, ny-Germano, Leticia, Sathler, Luciana B, Brito-Moreira, Jordano, Houzel, Jean-Christophe, Decker, Helena, Silverman, Michael A, Kazi, Hala, Melo, Helen M, McClean, Paula L, Holscher, Christian, Arnold, Steven E, Talbot, Konrad, Klein, William L, Munoz, Douglas P, Ferreira, Sergio T, De Felice, Fernanda G

“…Defective brain insulin signaling has been suggested to contribute to the cognitive deficits in patients with Alzheimer's disease (AD). Although a connection…”
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