Search Results - "Deck, Lorraine M."

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression by Le, Anne, Cooper, Charles R, Gouw, Arvin M, Dinavahi, Ramani, Maitra, Anirban, Deck, Lorraine M, Royer, Robert E, Vander Jagt, David L, Semenza, Gregg L, Dang, Chi V

“…As the result of genetic alterations and tumor hypoxia, many cancer cells avidly take up glucose and generate lactate through lactate dehydrogenase A (LDHA),…”
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A chemical analog of curcumin as an improved inhibitor of amyloid Abeta oligomerization by Orlando, Robert A, Gonzales, Amanda M, Royer, Robert E, Deck, Lorraine M, Vander Jagt, David L

“…Amyloid-like plaques are characteristic lesions defining the neuropathology of Alzheimer's disease (AD). The size and density of these plaques are closely…”
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Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes by Deck, Lorraine M., Whalen, Lisa J., Hunsaker, Lucy A., Royer, Robert E., Vander Jagt, David L.

“…[Display omitted] Nrf2, which is a member of the cap’n’collar family of transcription factors, is a major regulator of phase II detoxification and anti-oxidant…”
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The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells by Fajardo, Alexandra M., MacKenzie, Debra A., Ji, Ming, Deck, Lorraine M., Jagt, David L. Vander, Thompson, Todd A., Bisoffi, Marco

“…BACKGROUND The androgen receptor (AR) plays a critical role in prostate cancer development and progression. Therefore, the inhibition of AR function is an…”
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Comparative Structural Analysis and Kinetic Properties of Lactate Dehydrogenases from the Four Species of Human Malarial Parasites by Brown, W. Michael, Yowell, Charles A, Hoard, Anna, Vander Jagt, Thomas A, Hunsaker, Lucy A, Deck, Lorraine M, Royer, Robert E, Piper, Robert C, Dame, John B, Makler, Michael T, Vander Jagt, David L

“…Parasite lactate dehydrogenase (pLDH) is a potential drug target for new antimalarials owing to parasite dependence on glycolysis for ATP production. The pLDH…”
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Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin by Deck, Lorraine M., Hunsaker, Lucy A., Vander Jagt, Thomas A., Whalen, Lisa J., Royer, Robert E., Vander Jagt, David L.

“…Inflammation and oxidative stress are common in many chronic diseases. Targeting signaling pathways that contribute to these conditions may have therapeutic…”
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Anti-oxidant activities of curcumin and related enones by Weber, Waylon M., Hunsaker, Lucy A., Abcouwer, Steve F., Deck, Lorraine M., Vander Jagt, David L.

“…[Display omitted] The natural product curcumin (diferuloylmethane, 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), obtained from the spice…”
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Substituted trans-Stilbenes, Including Analogues of the Natural Product Resveratrol, Inhibit the Human Tumor Necrosis Factor Alpha-Induced Activation of Transcription Factor Nuclear Factor KappaB by Heynekamp, Justin J, Weber, Waylon M, Hunsaker, Lucy A, Gonzales, Amanda M, Orlando, Robert A, Deck, Lorraine M, Vander Jagt, David L

“…The transcription factor nuclear factor kappaB (NF-κB), which regulates expression of numerous antiinflammatory genes as well as genes that promote development…”
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Optical and SPION-enhanced MR imaging shows that trans-stilbene inhibitors of NF-κB concomitantly lower Alzheimer's disease plaque formation and microglial activation in AβPP/PS-1 transgenic mouse brain by Solberg, Nathan O, Chamberlin, Ryan, Vigil, Jenette R, Deck, Lorraine M, Heidrich, John E, Brown, David C, Brady, Christina I, Vander Jagt, Thomas A, Garwood, Michael, Bisoffi, Marco, Severns, Virginia, Vander Jagt, David L, Sillerud, Laurel O

“…Alzheimer's disease (AD) is associated with a microglia-dependent neuroinflammatory response against plaques containing the fibrous protein amyloid-β (Aβ)…”
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Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum by Gomez, Manuel S, Piper, Robert C, Hunsaker, Lucy A, Royer, Robert E, Deck, Lorraine M, Makler, Michael T, Vander Jagt, David L

“…Lactate dehydrogenase from the malarial parasite Plasmodium falciparum has many amino acid residues that are unique compared to any other known lactate…”
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Syntheses of methylpyridine and methylpyridine N-oxide decorated benzoxazine and naphthoxazine platforms by Deck, Lorraine M., Paine, Robert T., Bright, Elizabeth R., Ouizem, Sabrina, Dickie, Diane A.

“…Simple, aqueous-based syntheses of methylpyridine and methylpyridine N-oxide decorated 3,4-dihydro-2H-naphthoxazine and 2,3-dihydro-1H-naphthoxazine monomers,…”
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Activation of NFκB is inhibited by curcumin and related enones by Weber, Waylon M., Hunsaker, Lucy A., Roybal, C. Nathaniel, Bobrovnikova-Marjon, Ekaterina V., Abcouwer, Steve F., Royer, Robert E., Deck, Lorraine M., Vander Jagt, David L.

“…The transcription factor NFkappaB (NFκB) is up-regulated in many cancer cells where it contributes to development of the pro-survival, anti-apoptotic state…”
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Isocoumarin-based inhibitors of pancreatic cholesterol esterase by Heynekamp, Justin J., Hunsaker, Lucy A., Vander Jagt, Thomas A., Royer, Robert E., Deck, Lorraine M., Vander Jagt, David L.

“…Pancreatic cholesterol esterase (CEase), which is secreted from the exocrine pancreas, is a serine hydrolase that aids in the bile salt-dependent hydrolysis of…”
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Synthesis and Anti-HIV Activity of 1,1'-Dideoxygossypol and Related Compounds by Royer, Robert E, Deck, Lorraine M, Vander Jagt, Timothy J, Martinez, Francella J, Mills, Ray G, Young, Stephen A, Vander Jagt, David L

“…1,1'-Dideoxygossypol (DDG), 1,1'-dideoxygossylic acid (DDGA), 8-deoxyhemigossypol (DHG), and 8-deoxyhemigossylic acid (DHGA) were synthesized and tested for…”
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TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin by Weber, Waylon M., Hunsaker, Lucy A., Gonzales, Amanda M., Heynekamp, Justin J., Orlando, Robert A., Deck, Lorraine M., Vander Jagt, David L.

“…The activator protein-1 (AP-1) family of transcription factors, including the most common member c-Jun-c-Fos, participates in regulation of expression of…”
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Synthesis of hemigossypol and its derivatives by Wei, Jun, Jagt, David L. Vander, Royer, Robert E., Deck, Lorraine M.

“…Hemigossypol ( 3), a sesquiterpene natural product, was previously isolated from Gossypium barbadense and was shown to display improved anti-fungal activity…”
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Synthesis of benzyl substituted naphthalenes from benzylidene tetralones by Deck, Lorraine M., Mgani, Quintino, Martinez, Andrea, Martinic, Alice, Whalen, Lisa J., Vander Jagt, David L., Royer, Robert E.

“…A convenient and efficient synthesis of novel highly substituted dimethoxybenzylnaphthalenes, which are precursors to several dihydroxynaphthoic acids, is…”
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Natural products inhibit LPS-induced activation of pro-inflammatory cytokines in peripheral blood mononuclear cells by Shah, Vallabh O., Ferguson, Jeannette E., Hunsaker, Lucy A., Deck, Lorraine M., Vander Jagt, David L.

“…Haemodialysis (HD) patients have many biochemical, immune and inflammatory alterations that can lead to an increased risk for cardiovascular disease. The two…”
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Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4 by YUE YU, DECK, Jason A, HUNSAKER, Lucy A, DECK, Lorraine M, ROYER, Robert E, GOLDBERG, Erwin, VANDER JAGT, David L

“…Human lactate dehydrogenases (LDH-A4, -B4, and -C4) are highly homologous with 84-89% sequence similarities and 69-75% amino acid identities. Active site…”
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Oxidation Reactivity Channels for 2-(Pyridin-2-yl)-N,N-diphenylacetamides by Pailloux, Sylvie, Binyamin, Iris, Deck, Lorraine M, Rapko, Brian M, Hay, Benjamin P, Duesler, Eileen N, Paine, Robert T

“…Synthetic routes to 2-(pyridin-2-yl)-N,N-diphenylacetamide and 2-(6-methylpyridin-2-yl)-N,N-diphenyl-acetamide are described along with results from the…”
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