Extradural bupivacaine with sufentanil for vaginal delivery. A double-blind trial

Extradural bupivacaine with sufentanil for vaginal delivery. A double-blind trial

The combination of sufentanil with bupivacaine plus adrenaline given extradurally for pain relief during labour was studied in a double-blind trial. One hundred and twenty patients were randomly divided into three groups and received a 10-ml extradural injection of sufentanil 15 micrograms + bupivac...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA Vol. 59; no. 12; p. 1518
Main Authors: Van Steenberge, A, Debroux, H C, Noorduin, H
Format: Journal Article
Language:English
Published: England 01-12-1987
Subjects:
Adult
Anesthesia, Epidural
Anesthesia, Obstetrical
Bupivacaine - pharmacology
Clinical Trials as Topic
Delivery, Obstetric
Double-Blind Method
Drug Interactions
Female
Fentanyl - analogs & derivatives
Fentanyl - pharmacology
Humans
Infant, Newborn
Labor, Obstetric - drug effects
Pregnancy
Sufentanil
Time Factors
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Summary:The combination of sufentanil with bupivacaine plus adrenaline given extradurally for pain relief during labour was studied in a double-blind trial. One hundred and twenty patients were randomly divided into three groups and received a 10-ml extradural injection of sufentanil 15 micrograms + bupivacaine 12.5 mg + adrenaline 12.5 micrograms, sufentanil 7.5 micrograms + bupivacaine 12.5 mg + adrenaline 12.5 micrograms, or bupivacaine 12.5 mg + adrenaline 12.5 micrograms (control group). A second injection, which was given upon request, was identical to the first. Subsequently, patients received a further 10 ml of bupivacaine + adrenaline, if required. The addition of sufentanil significantly decreased the latency, and increased the duration, of the analgesia. Moreover, the quality of analgesia was better and less bupivacaine was required, resulting in less motor blockade at delivery. There were no differences between the three groups in regard to Apgar scores. The only side effect of sufentanil was pruritus.
ISSN:0007-0912
DOI:10.1093/bja/59.12.1518