Search Results - "Deboux, Cyrille"

Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination by Wegener, Amélie, Deboux, Cyrille, Bachelin, Corinne, Frah, Magali, Kerninon, Christophe, Seilhean, Danielle, Weider, Matthias, Wegner, Michael, Nait-Oumesmar, Brahim

“…The basic helix-loop-helix transcription factor Olig2 is a key determinant for the specification of neural precursor cells into oligodendrocyte progenitor…”
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Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum by Meffre, Delphine, Shackleford, Ghjuvan’Ghjacumu, Hichor, Mehdi, Gorgievski, Victor, Tzavara, Eleni T., Trousson, Amalia, Ghoumari, Abdel M., Deboux, Cyrille, Oumesmar, Brahim Nait, Liere, Philippe, Schumacher, Michael, Baulieu, Etienne-Emile, Charbonnier, Frédéric, Grenier, Julien, Massaad, Charbel

“…The identification of new pathways governing myelination provides innovative avenues for remyelination. Liver X receptors (LXRs) α and β are nuclear receptors…”
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Modulation of the Innate Immune Response by Human Neural Precursors Prevails over Oligodendrocyte Progenitor Remyelination to Rescue a Severe Model of Pelizaeus‐Merzbacher Disease by Marteyn, Antoine, Sarrazin, Nadège, Yan, Jun, Bachelin, Corinne, Deboux, Cyrille, Santin, Mathieu D., Gressens, Pierre, Zujovic, Violetta, Baron‐Van Evercooren, Anne

“…Pelizaeus‐Merzbacher disease (PMD) results from an X‐linked misexpression of proteolipid protein 1 (PLP1). This leukodystrophy causes severe hypomyelination…”
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Skin-derived neural precursors competitively generate functional myelin in adult demyelinated mice by Mozafari, Sabah, Laterza, Cecilia, Roussel, Delphine, Bachelin, Corinne, Marteyn, Antoine, Deboux, Cyrille, Martino, Gianvito, Baron-Van Evercooren, Anne

“…Induced pluripotent stem cell-derived (iPS-derived) neural precursor cells may represent the ideal autologous cell source for cell-based therapy to promote…”
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Overexpression of CD44 in neural precursor cells improves trans-endothelial migration and facilitates their invasion of perivascular tissues in vivo by Deboux, Cyrille, Ladraa, Sophia, Cazaubon, Sylvie, Ghribi-Mallah, Siham, Weiss, Nicolas, Chaverot, Nathalie, Couraud, Pierre Olivier, Baron-Van Evercooren, Anne

“…Neural precursor (NPC) based therapies are used to restore neurons or oligodendrocytes and/or provide neuroprotection in a large variety of neurological…”
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Boundary cap cells are peripheral nervous system stem cells that can be redirected into central nervous system lineages by Zujovic, Violetta, Thibaud, Julie, Bachelin, Corinne, Vidal, Marie, Deboux, Cyrille, Coulpier, Fanny, Stadler, Nicolas, Charnay, Patrick, Topilko, Piotr, Baron-Van Evercooren, Anne

“…Boundary cap cells (BC), which express the transcription factor Krox20, participate in the formation of the boundary between the central nervous system and the…”
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Beneficial contribution of induced pluripotent stem cell‐progeny to Connexin 47 dynamics during demyelination‐remyelination by Mozafari, Sabah, Deboux, Cyrille, Laterza, Cecilia, Ehrlich, Marc, Kuhlmann, Tanja, Martino, Gianvito, Baron‐Van Evercooren, Anne

“…Oligodendrocytes are extensively coupled to astrocytes, a phenomenon ensuring glial homeostasis and maintenance of central nervous system myelin. Molecular…”
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Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling by Garcia-Diaz, Beatriz, Bachelin, Corinne, Coulpier, Fanny, Gerschenfeld, Gaspard, Deboux, Cyrille, Zujovic, Violetta, Charnay, Patrick, Topilko, Piotr, Baron-Van Evercooren, Anne

“…Schwann cells (SC) enter the central nervous system (CNS) in pathophysiological conditions. However, how SC invade the CNS to remyelinate central axons remains…”
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Satellite glia of the adult dorsal root ganglia harbor stem cells that yield glia under physiological conditions and neurons in response to injury by Maniglier, Madlyne, Vidal, Marie, Bachelin, Corinne, Deboux, Cyrille, Chazot, Jérémy, Garcia-Diaz, Beatriz, Baron-Van Evercooren, Anne

“…The presence of putative stem/progenitor cells has been suggested in adult peripheral nervous system (PNS) tissue, including the dorsal root ganglion (DRG). To…”
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Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation by Aït Amiri, Sabrina, Deboux, Cyrille, Soualmia, Feryel, Chaaya, Nancy, Louet, Maxime, Duplus, Eric, Betuing, Sandrine, Nait Oumesmar, Brahim, Masurier, Nicolas, El Amri, Chahrazade

“…Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) that causes severe motor, sensory, and cognitive…”
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Antagonistic actions of PAK1 and NF2/Merlin drive myelin membrane expansion in oligodendrocytes by Baudouin, Lucas, Adès, Noémie, Kanté, Kadia, Bachelin, Corinne, Hmidan, Hatem, Deboux, Cyrille, Panic, Radmila, Ben Messaoud, Rémy, Velut, Yoan, Hamada, Soumia, Pionneau, Cédric, Duarte, Kévin, Poëa‐Guyon, Sandrine, Barnier, Jean‐Vianney, Nait Oumesmar, Brahim, Bouslama‐Oueghlani, Lamia

“…In the central nervous system, the formation of myelin by oligodendrocytes (OLs) relies on the switch from the polymerization of the actin cytoskeleton to its…”
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Adult DRG Stem/Progenitor Cells Generate Pericytes in the Presence of Central Nervous System (CNS) Developmental Cues, and Schwann Cells in Response to CNS Demyelination by Vidal, Marie, Maniglier, Madlyne, Deboux, Cyrille, Bachelin, Corinne, Zujovic, Violetta, Baron‐Van Evercooren, Anne

“…It has been proposed that the adult dorsal root ganglia (DRG) harbor neural stem/progenitor cells (NPCs) derived from the neural crest. However, the thorough…”
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Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord by BUCHET, Delphine, GARCIA, Corina, DEBOUX, Cyrille, NAIT-OUMESMAR, Brahim, BARON-VAN EVERCOOREN, Anne

“…Improving oligodendroglial differentiation from human foetal neural progenitor cells remains a primordial issue to accomplish successful cell-based therapies…”
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SOX17 transcription factor negatively regulates oligodendrocyte precursor cell differentiation by Fauveau, Melissa, Wilmet, Baptiste, Deboux, Cyrille, Benardais, Karelle, Bachelin, Corinne, Temporão, Ana C., Kerninon, Christophe, Nait Oumesmar, Brahim

“…Oligodendrocyte development is a critical process timely and spatially regulated to ensure proper myelination of the central nervous system. HMG‐box…”
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Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system by Caillava, Céline, Vandenbosch, Renaud, Jablonska, Beata, Deboux, Cyrille, Spigoni, Giulia, Gallo, Vittorio, Malgrange, Brigitte, Baron-Van Evercooren, Anne

“…The specific functions of intrinsic regulators of oligodendrocyte progenitor cell (OPC) division are poorly understood. Type 2 cyclin-dependent kinase (Cdk2)…”
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IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells by Weiss, Nicolas, Deboux, Cyrille, Chaverot, Nathalie, Miller, Florence, Baron-Van Evercooren, Anne, Couraud, Pierre-Olivier, Cazaubon, Sylvie

“…Abstract It has been recently shown that systemically injected neural precursor cells (NPCs) could cross brain endothelium and favor functional recovery in…”
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Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum by Meffre, Delphine, Shackleford, Ghjuvan’ghjacumu, Hichor, Mehdi, Gorgievski, Victor, Tzavara, Eleni, Trousson, Amalia, Ghoumari, Abdel M, Deboux, Cyrille, Nait Oumesmar, Brahim, Liere, Philippe, Schumacher, Michael, Baulieu, Etienne-Emile, Charbonnier, Frédéric, Grenier, Julien, Massaad, Charbel

“…Significance Liver X receptors (LXRs) α and β are the two major receptors of oxysterols, oxygenated derivatives of cholesterol. They control the homeostasis of…”
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p70S6 kinase regulates oligodendrocyte differentiation and is active in remyelinating lesions by Benardais, Karelle, Ornelas, Isis M., Fauveau, Melissa, Brown, Tanya L., Finseth, Lisbet T., Panic, Radmila, Deboux, Cyrille, Macklin, Wendy B., Wood, Teresa L., Nait-Oumesmar, Brahim

“…Abstract The p70 ribosomal S6 kinases (p70 ribosomal S6 kinase 1 and p70 ribosomal S6 kinase 2) are downstream targets of the mechanistic target of rapamycin…”
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Directing human neural stem/precursor cells into oligodendrocytes by overexpression of Olig2 transcription factor by Maire, Cécile L., Buchet, Delphine, Kerninon, Christophe, Deboux, Cyrille, Baron-Van Evercooren, Anne, Nait-Oumesmar, Brahim

“…Multipotential neural stem/precursor cells of the central nervous system were extensively studied for their properties of generating myelinating…”
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Molecular Mechanism of Systemic Delivery of Neural Precursor Cells to the Brain: Assembly of Brain Endothelial Apical Cups and Control of Transmigration by CD44 by Rampon, Christine, Weiss, Nicolas, Deboux, Cyrille, Chaverot, Nathalie, Miller, Florence, Buchet, Delphine, Tricoire‐Leignel, Hélène, Cazaubon, Sylvie, Baron‐Van Evercooren, Anne, Couraud, Pierre‐Olivier

“…Systemically injected neural precursor cells (NPCs) were unexpectedly shown to reach the cerebral parenchyma and induce recovery in various diffuse brain…”
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