Search Results - "Deborah Novelli"

Pentraxin 3 in Cardiovascular Disease by Ristagno, Giuseppe, Fumagalli, Francesca, Bottazzi, Barbara, Mantovani, Alberto, Olivari, Davide, Novelli, Deborah, Latini, Roberto

“…The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial…”
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Characterization of the Cardiac Structure and Function of Conscious D2.B10-Dmdmdx/J (D2-mdx) mice from 16–17 to 24–25 Weeks of Age by De Giorgio, Daria, Novelli, Deborah, Motta, Francesca, Cerrato, Marianna, Olivari, Davide, Salama, Annasimon, Fumagalli, Francesca, Latini, Roberto, Staszewsky, Lidia, Crippa, Luca, Steinkühler, Christian, Licandro, Simonetta Andrea

“…Duchenne muscular dystrophy (DMD) is the most common form of muscle degenerative hereditary disease. Muscular replacement by fibrosis and calcification are the…”
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Monocrotaline-induced pulmonary arterial hypertension: Time-course of injury and comparative evaluation of macitentan and Y-27632, a Rho kinase inhibitor by Novelli, Deborah, Fumagalli, Francesca, Staszewsky, Lidia, Ristagno, Giuseppe, Olivari, Davide, Masson, Serge, De Giorgio, Daria, Ceriani, Sabina, Affatato, Roberta, De Logu, Francesco, Nassini, Romina, Milioli, Marco, Facchinetti, Fabrizio, Cantoni, Silvia, Trevisani, Marcello, Letizia, Teresa, Russo, Ilaria, Salio, Monica, Latini, Roberto

“…Novel pharmacological approaches are needed to improve outcomes of patients with idiopathic pulmonary hypertension. Rho-associated protein kinase (ROCK)…”
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LUCAS Versus Manual Chest Compression During Ambulance Transport: A Hemodynamic Study in a Porcine Model of Cardiac Arrest by Magliocca, Aurora, Olivari, Davide, De Giorgio, Daria, Zani, Davide, Manfredi, Martina, Boccardo, Antonio, Cucino, Alberto, Sala, Giulia, Babini, Giovanni, Ruggeri, Laura, Novelli, Deborah, Skrifvars, Markus B, Hardig, Bjarne Madsen, Pravettoni, Davide, Staszewsky, Lidia, Latini, Roberto, Belloli, Angelo, Ristagno, Giuseppe

“…Background Mechanical chest compression (CC) is currently suggested to deliver sustained high-quality CC in a moving ambulance. This study compared the…”
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Esmolol during cardiopulmonary resuscitation reduces neurological injury in a porcine model of cardiac arrest by Ruggeri, Laura, Nespoli, Francesca, Ristagno, Giuseppe, Fumagalli, Francesca, Boccardo, Antonio, Olivari, Davide, Affatato, Roberta, Novelli, Deborah, De Giorgio, Daria, Romanelli, Pierpaolo, Minoli, Lucia, Cucino, Alberto, Babini, Giovanni, Staszewsky, Lidia, Zani, Davide, Pravettoni, Davide, Belloli, Angelo, Scanziani, Eugenio, Latini, Roberto, Magliocca, Aurora

“…Primary vasopressor efficacy of epinephrine during cardiopulmonary resuscitation (CPR) is due to its α-adrenergic effects. However, epinephrine plays…”
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Total NT-proBNP, a novel biomarker related to recurrent atrial fibrillation by Staszewsky, Lidia, Meessen, Jennifer M T A, Novelli, Deborah, Wienhues-Thelen, Ursula-Henrike, Disertori, Marcello, Maggioni, Aldo P, Masson, Serge, Tognoni, Gianni, Franzosi, Maria Grazia, Lucci, Donata, Latini, Roberto

“…Novel circulating biomarkers may help in understanding the underlying mechanisms of atrial fibrillation (AF), a challenge for AF management and prevention of…”
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Ventilation With Argon Improves Survival With Good Neurological Recovery After Prolonged Untreated Cardiac Arrest in Pigs by Fumagalli, Francesca, Olivari, Davide, Boccardo, Antonio, De Giorgio, Daria, Affatato, Roberta, Ceriani, Sabina, Bariselli, Simone, Sala, Giulia, Cucino, Alberto, Zani, Davide, Novelli, Deborah, Babini, Giovanni, Magliocca, Aurora, Russo, Ilaria, Staszewsky, Lidia, Salio, Monica, Lucchetti, Jacopo, Maisano, Antonio Marco, Fiordaliso, Fabio, Furlan, Roberto, Gobbi, Marco, Luini, Mario Vittorio, Pravettoni, Davide, Scanziani, Eugenio, Belloli, Angelo, Latini, Roberto, Ristagno, Giuseppe

“…Background Ventilation with the noble gas argon (Ar) has shown neuroprotective and cardioprotective properties in different in vitro and in vivo models. Hence,…”
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Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest by Lucchetti, Jacopo, Fumagalli, Francesca, Olivari, Davide, Affatato, Roberta, Fracasso, Claudia, De Giorgio, Daria, Perego, Carlo, Motta, Francesca, Passoni, Alice, Staszewsky, Lidia, Novelli, Deborah, Magliocca, Aurora, Garattini, Silvio, Latini, Roberto, Ristagno, Giuseppe, Gobbi, Marco

“…Background Brain injury and neurological deficit are consequences of cardiac arrest (CA), leading to high morbidity and mortality. Peripheral activation of the…”
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Patient-reported outcome measures in patients with familial cerebral cavernous malformations: results from the Treat_CCM trial by Meessen, Jennifer M T A, Abete-Fornara, Giorgia, Zarino, Barbara, Castori, Marco, Tassi, Laura, Carriero, Maria R, D'Alessandris, Q G, Al-Shahi Salman, R, Blanda, Adriana, Nicolis, Enrico B, Novelli, Deborah, Caruana, Maria, Vasamì, Antonella, Lanfranconi, Silvia, Latini, Roberto

“…The Phase 1/2 Treat_CCM randomized controlled trial for people with familial cerebral cavernous malformations (FCCMs) confirmed the safety of propranolol and…”
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IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study by Meessen, Jennifer M. T. A., Cesaroni, Giulia, Mureddu, Gian F., Boccanelli, Alessandro, Wienhues-Thelen, Ursula-Henrike, Kastner, Peter, Ojeda-Fernandez, Luisa, Novelli, Deborah, Bazzoni, Gianfranco, Mangiavacchi, Maurizio, Agabiti, Nera, Masson, Serge, Staszewsky, Lidia, Latini, Roberto

“…Abstract Background Little is known about the clinical value of Insulin-like growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, in an…”
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Multicentre longitudinal study of fluid and neuroimaging BIOmarkers of AXonal injury after traumatic brain injury: the BIO-AX-TBI study protocol by Graham, Neil Samuel Nyholm, Zimmerman, Karl A, Bertolini, Guido, Magnoni, Sandra, Oddo, Mauro, Zetterberg, Henrik, Moro, Federico, Novelli, Deborah, Heslegrave, Amanda, Chieregato, Arturo, Fainardi, Enrico, Fleming, Joanne M, Garbero, Elena, Abed-Maillard, Samia, Gradisek, Primoz, Bernini, Adriano, Sharp, David J

“…Introduction and aimsTraumatic brain injury (TBI) often results in persistent disability, due particularly to cognitive impairments. Outcomes remain difficult…”
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Investigating the characteristics and correlates of systemic inflammation after traumatic brain injury: the TBI-BraINFLAMM study by Li, Lucia M, Heslegrave, Amanda, Soreq, Eyal, Nattino, Giovanni, Rosnati, Margherita, Garbero, Elena, Zimmerman, Karl A, Graham, Neil S N, Moro, Federico, Novelli, Deborah, Gradisek, Primoz, Magnoni, Sandra, Glocker, Ben, Zetterberg, Henrik, Bertolini, Guido, Sharp, David J

“…IntroductionA significant environmental risk factor for neurodegenerative disease is traumatic brain injury (TBI). However, it is not clear how TBI results in…”
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Albumin Oxidation Status in Sepsis Patients Treated With Albumin or Crystalloids by Bonifazi, Matteo, Meessen, Jennifer, Pérez, Alba, Vasques, Francesco, Busana, Mattia, Vassalli, Francesco, Novelli, Deborah, Bernasconi, Roberto, Signori, Chiara, Masson, Serge, Romitti, Federica, Giosa, Lorenzo, Macrì, Matteo, Pasticci, Iacopo, Palumbo, Maria Michela, Mota, Francisco, Costa, Montserrat, Caironi, Pietro, Latini, Roberto, Quintel, Michael, Gattinoni, Luciano

“…Inflammation and oxidative stress characterize sepsis and determine its severity. In this study, we investigated the relationship between albumin oxidation and…”
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Relation between plasma ceramides and cardiovascular death in chronic heart failure: A subset analysis of the GISSI‐HF trial by Targher, Giovanni, Lunardi, Gianluigi, Mantovani, Alessandro, Meessen, Jennifer, Bonapace, Stefano, Temporelli, Pier Luigi, Nicolis, Enrico, Novelli, Deborah, Conti, Antonio, Tavazzi, Luigi, Maggioni, Aldo Pietro, Latini, Roberto

“…Aims Ceramides exert several biological activities that may contribute to the pathophysiology of cardiovascular disease and heart failure (HF). The association…”
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Ranolazine ameliorates postresuscitation electrical instability and myocardial dysfunction and improves survival with good neurologic recovery in a rat model of cardiac arrest by Fumagalli, Francesca, MBiotech, Russo, Ilaria, MBiol, Staszewsky, Lidia, MD, Li, Yongqin, MSEE, PhD, Letizia, Teresa, MD, Masson, Serge, PhD, Novelli, Deborah, MBiol, Rocchetti, Marcella, PhD, Canovi, Mara, PhD, Veglianese, Pietro, PhD, Gobbi, Marco, PhD, Latini, Roberto, MD, Zaza, Antonio, MD, Ristagno, Giuseppe, MD, PhD

“…Background During ischemia, enhancement of the “late Na+ current” (INaL ) contributes to intracellular Ca2+ overload. Dysregulation of intracellular Ca2+…”
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Primary pulmonary arterial hypertension: Protocol to assess comprehensively in the rat the response to pharmacologic treatments by Novelli, Deborah, Fumagalli, Francesca, Staszewsky, Lidia, Ristagno, Giuseppe, Olivari, Davide, Masson, Serge, De Giorgio, Daria, Ceriani, Sabina, Massafra, Roberta, De Logu, Francesco, Nassini, Romina, Milioli, Marco, Facchinetti, Fabrizio, Cantoni, Silvia, Trevisani, Marcello, Letizia, Teresa, Russo, Ilaria, Salio, Monica, Latini, Roberto

“…[Display omitted] The identification of new treatments for primary pulmonary arterial hypertension (PAH) is a critical unmet need since there is no a…”
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Prospective study on microangiopathy in type 2 diabetic foot ulcer by Fiordaliso, Fabio, Clerici, Giacomo, Maggioni, Serena, Caminiti, Maurizio, Bisighini, Cinzia, Novelli, Deborah, Minnella, Daniela, Corbelli, Alessandro, Morisi, Riccardo, De Iaco, Alberto, Faglia, Ezio

“…Aims/hypothesis We investigated the significance of microangiopathy in the development of foot ulcer, which is still disputed. Methods We assessed…”
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Characterization of the Cardiac Structure and Function of Conscious D2.B10-IDmdmdx/I/J mice from 16–17 to 24–25 Weeks of Age by De Giorgio, Daria, Novelli, Deborah, Motta, Francesca, Cerrato, Marianna, Olivari, Davide, Salama, Annasimon, Fumagalli, Francesca, Latini, Roberto, Staszewsky, Lidia, Crippa, Luca, Steinkühler, Christian, Licandro, Simonetta Andrea

“…Duchenne muscular dystrophy (DMD) is the most common form of muscle degenerative hereditary disease. Muscular replacement by fibrosis and calcification are the…”
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Abstract 262: Hemodynamically-Guided Optimum Chest Compression Point in a Rat Model of Cardiopulmonary Resuscitation by Olivari, Davide, De Giorgio, Daria, Novelli, Deborah, Magliocca, Aurora, Ruggeri, Laura, Ristagno, Giuseppe

“…Abstract only Introduction: CPR aims to re-establish blood flow by chest compression (CC), achieving threshold levels of coronary perfusion pressure (CPP). For…”
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The role of resistin and myeloperoxidase in severe sepsis and septic shock: Results from the ALBIOS trial by Bonaventura, Aldo, Carbone, Federico, Vecchié, Alessandra, Meessen, Jennifer, Ferraris, Sandra, Beck, Eduardo, Keim, Roberto, Minetti, Silvia, Elia, Edoardo, Ferrara, Daniele, Ansaldo, Anna Maria, Novelli, Deborah, Caironi, Pietro, Latini, Roberto, Montecucco, Fabrizio

“…Background Inflammatory biomarkers are useful in detecting patients with sepsis. The prognostic role of resistin and myeloperoxidase (MPO) has been…”
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