Search Results - "Debnath, Asim K"

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41 by Lu, Lu, Yu, Fei, Cai, Lifeng, Debnath, Asim K, Jiang, Shibo

“…Human immunodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein surface subunit gp120 and transmembrane subunit gp41 play important roles in HIV-1…”
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Envelope Protein-Targeting Zika Virus Entry Inhibitors by Roy, Abhijeet, Liu, Qian, Yang, Yang, Debnath, Asim K, Du, Lanying

“…Zika virus (ZIKV; family, ), which causes congenital Zika syndrome, Guillain-Barré Syndrome, and other severe diseases, is transmitted mainly by mosquitoes;…”
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Identification of Novel Natural Products as Effective and Broad-Spectrum Anti-Zika Virus Inhibitors by Gao, Yaning, Tai, Wanbo, Wang, Ning, Li, Xiang, Jiang, Shibo, Debnath, Asim K, Du, Lanying, Chen, Shizhong

“…Zika virus (ZIKV) infection during pregnancy leads to severe congenital Zika syndrome, which includes microcephaly and other neurological malformations. No…”
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Identification of a Receptor-Binding Domain in the S Protein of the Novel Human Coronavirus Middle East Respiratory Syndrome Coronavirus as an Essential Target for Vaccine Development by Du, Lanying, Zhao, Guangyu, Kou, Zhihua, Ma, Cuiqing, Sun, Shihui, Poon, Vincent K M, Lu, Lu, Wang, Lili, Debnath, Asim K, Zheng, Bo-Jian, Zhou, Yusen, Jiang, Shibo

“…Erratum ( vol. 87 , p. 11963 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops by Kwon, Young Do, Finzi, Andrés, Wu, Xueling, Dogo-Isonagie, Cajetan, Lee, Lawrence K, Moore, Lucas R, Schmidt, Stephen D, Stuckey, Jonathan, Yang, Yongping, Zhou, Tongqing, Zhu, Jiang, Vicic, David A, Debnath, Asim K, Shapiro, Lawrence, Bewley, Carole A, Mascola, John R, Sodroski, Joseph G, Kwong, Peter D

“…The HIV-1 envelope (Env) spike (gp1203/gp413) undergoes considerable structural rearrangements to mediate virus entry into cells and to evade the host immune…”
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A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity by Gao, Yaning, Tai, Wanbo, Wang, Xinyi, Jiang, Shibo, Debnath, Asim K, Du, Lanying, Chen, Shizhong

“…Zika virus (ZIKV) and dengue virus (DENV) cause microcephaly and dengue hemorrhagic fever, respectively, leading to severe problems. No effective antiviral…”
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Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists by Curreli, Francesca, Kwon, Young D, Nicolau, Isabella, Burgos, Giancarla, Altieri, Andrea, Kurkin, Alexander V, Verardi, Raffaello, Kwong, Peter D, Debnath, Asim K

“…As part of our effort to discover drugs that target HIV-1 entry, we report the antiviral activity and crystal structures of two novel inhibitors in a complex…”
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Comparative Pharmacokinetics of a Dual Inhibitor of HIV-1, NBD-14189, in Rats and Dogs with a Proof-of-Concept Evaluation of Antiviral Potency in SCID-hu Mouse Model by Stoddart, Cheryl A, Curreli, Francesca, Horrigan, Stephen, Altieri, Andrea, Kurkin, Alexander V, Debnath, Asim K

“…We earlier reported substantial progress in designing gp120 antagonists. Notably, we discovered that NBD-14189 is not only the most active gp120 antagonist but…”
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Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors by Curreli, Francesca, Chau, Kent, Tran, Thanh-Thuy, Nicolau, Isabella, Ahmed, Shahad, Das, Pujita, Hillyer, Christopher D, Premenko-Lanier, Mary, Debnath, Asim K

“…The unprecedented pandemic of COVID-19, caused by a novel coronavirus, SARS-CoV-2, and its highly transmissible variants, led to massive human suffering,…”
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Design, Synthesis, and Structure−Activity Relationship of a Novel Series of 2-Aryl 5-(4-Oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 Entry Inhibitors by Katritzky, Alan R, Tala, Srinivasa R, Lu, Hong, Vakulenko, Anatoliy V, Chen, Qi-Yin, Sivapackiam, Jothilingam, Pandya, Keyur, Jiang, Shibo, Debnath, Asim K

“…We previously identified two small molecules targeting the HIV-1 gp41, N-(4-carboxy-3-hydroxy)phenyl-2,5-dimethylpyrrole 12 (NB-2) and…”
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Solution Structure of a Hydrocarbon Stapled Peptide Inhibitor in Complex with Monomeric C-terminal Domain of HIV-1 Capsid by Bhattacharya, Shibani, Zhang, Hongtao, Debnath, Asim K., Cowburn, David

“…The human immunodeficiency virus type 1 (HIV-1) capsid protein plays a critical role in virus core particle assembly and is an important target for novel…”
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Binding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study by Curreli, Francesca, Kwon, Young Do, Zhang, Hongtao, Yang, Yongping, Scacalossi, Daniel, Kwong, Peter D, Debnath, Asim K

“…We previously identified two small-molecule CD4 mimetics--NBD-556 and NBD-557--and synthesized a series of NBD compounds that resulted in improved…”
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Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity by Curreli, Francesca, Belov, Dmitry S, Ramesh, Ranjith R, Patel, Naisargi, Altieri, Andrea, Kurkin, Alexander V, Debnath, Asim K

“…Since our first discovery of a CD4-mimic, NBD-556, which targets the Phe43 cavity of HIV-1 gp120, we and other groups made considerable progress in designing…”
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Identification of Combinations of Protein Kinase C Activators and Histone Deacetylase Inhibitors That Potently Reactivate Latent HIV by Curreli, Francesca, Ahmed, Shahad, Victor, Sofia M Benedict, Debnath, Asim K

“…Combination antiretroviral therapy (cART) is successful in maintaining undetectable levels of HIV in the blood; however, the persistence of latent HIV…”
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Design, Synthesis, and Biological Activity of Novel 5-((Arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 Fusion Inhibitors Targeting gp41 by Jiang, Shibo, Tala, Srinivasa R, Lu, Hong, Abo-Dya, Nader E, Avan, Ilker, Gyanda, Kapil, Lu, Lu, Katritzky, Alan R, Debnath, Asim K

“…On the basis of our earlier molecular docking analysis, we designed and synthesized…”
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Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors by Liu, Shuwen, Xiao, Gengfu, Chen, Yibang, He, Yuxian, Niu, Jinkui, Escalante, Carlos R, Xiong, Huabao, Farmar, James, Debnath, Asim K, Tien, Po, Jiang, Shibo

“…Studies on the fusion-inhibitory peptides derived from the heptad repeat 1 and 2 (HR1 and HR2) regions of the HIV-1 envelope glycoprotein gp41 provided crucial…”
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N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion by JIANG, Shibo, HONG LU, SHUWEN LIU, QIAN ZHAO, YUXIAN HE, DEBNATH, Asim K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4-binding site by Kwon, Young Do, LaLonde, Judith M, Yang, Yongping, Elban, Mark A, Sugawara, Akihiro, Courter, Joel R, Jones, David M, Smith, 3rd, Amos B, Debnath, Asim K, Kwong, Peter D

“…Efforts to develop therapeutic agents that inhibit HIV-1 entry have led to the identification of several small molecule leads. One of the most promising is the…”
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Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid by Curreli, Francesca, Zhang, Hongtao, Zhang, Xihui, Pyatkin, Ilya, Victor, Zagorodnikov, Altieri, Andrea, Debnath, Asim K.

“…The hydrophobic cavity of the C-terminal domain (CTD) of HIV-1 capsid has been recently validated as potential target for antiviral drugs by peptide-based…”
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Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays by Curreli, Francesca, Ahmed, Shahad, Victor, Sofia M B, Drelich, Aleksandra, Panda, Siva S, Altieri, Andrea, Kurkin, Alexander V, Tseng, Chien-Te K, Hillyer, Christopher D, Debnath, Asim K

“…We report the discovery of several highly potent small molecules with low-nM potency against severe acute respiratory syndrome coronavirus (SARS-CoV; lowest…”
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