Search Results - "Debiram, Irene"

Minimally invasive esophageal sponge cytology sampling is feasible in a Tanzanian community setting by Middleton, Daniel R. S., Mmbaga, Blandina T., O'Donovan, Maria, Abedi‐Ardekani, Behnoush, Debiram‐Beecham, Irene, Nyakunga‐Maro, Gissela, Maro, Venance, Bromwich, Martin, Daudi, Amini, Ngowi, Timothy, Minde, Rehema, Claver, Jackson, Mremi, Alex, Mwasamwaja, Amos, Schüz, Joachim, Fitzgerald, Rebecca C., McCormack, Valerie

“…Esophageal sponge cytology is an endoscopy alternative well accepted by patients with extensive data for accuracy in the context of adenocarcinoma. Few studies…”
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Prospective cohort study assessing outcomes of patients from families fulfilling criteria for hereditary diffuse gastric cancer undergoing endoscopic surveillance by Lim, Yean Cheant, MBChB, MRCP, di Pietro, Massimiliano, MD, O'Donovan, Maria, MD, FRCPath, Richardson, Susan, RGN, Debiram, Irene, MSc, Dwerryhouse, Susan, MSc, Hardwick, Richard H., MD, FRCS, Tischkowitz, Marc, PhD, MRCP, Caldas, Carlos, MD, FMedSci, Ragunath, Krish, MD, FRCP, Fitzgerald, Rebecca C., MD, FMedSci

“…Background Prophylactic total gastrectomy is performed in hereditary diffuse gastric cancer (HDGC) patients carrying the CDH1 mutation because endoscopic…”
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Evaluation of a minimally invasive cell sampling device coupled with assessment of trefoil factor 3 expression for diagnosing Barrett's esophagus: a multi-center case-control study by Ross-Innes, Caryn S, Debiram-Beecham, Irene, O'Donovan, Maria, Walker, Elaine, Varghese, Sibu, Lao-Sirieix, Pierre, Lovat, Laurence, Griffin, Michael, Ragunath, Krish, Haidry, Rehan, Sami, Sarmed S, Kaye, Philip, Novelli, Marco, Disep, Babett, Ostler, Richard, Aigret, Benoit, North, Bernard V, Bhandari, Pradeep, Haycock, Adam, Morris, Danielle, Attwood, Stephen, Dhar, Anjan, Rees, Colin, Rutter, Matthew D D, Sasieni, Peter D, Fitzgerald, Rebecca C

“…Barrett's esophagus (BE) is a commonly undiagnosed condition that predisposes to esophageal adenocarcinoma. Routine endoscopic screening for BE is not…”
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Barrett's oESophagus trial 3 (BEST3): study protocol for a randomised controlled trial comparing the Cytosponge-TFF3 test with usual care to facilitate the diagnosis of oesophageal pre-cancer in primary care patients with chronic acid reflux by Offman, Judith, Muldrew, Beth, O'Donovan, Maria, Debiram-Beecham, Irene, Pesola, Francesca, Kaimi, Irene, Smith, Samuel G, Wilson, Ashley, Khan, Zohrah, Lao-Sirieix, Pierre, Aigret, Benoit, Walter, Fiona M, Rubin, Greg, Morris, Steve, Jackson, Christopher, Sasieni, Peter, Fitzgerald, Rebecca C

“…Early detection of oesophageal cancer improves outcomes; however, the optimal strategy for identifying patients at increased risk from the pre-cancerous lesion…”
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Patient-reported experiences and views on the Cytosponge test: a mixed-methods analysis from the BEST3 trial by Maroni, Roberta, Barnes, Jessica, Offman, Judith, Scheibl, Fiona, Smith, Samuel G, Debiram-Beecham, Irene, Waller, Jo, Sasieni, Peter, Fitzgerald, Rebecca C, Rubin, Greg, Walter, Fiona M

“…ObjectivesThe BEST3 trial demonstrated the efficacy and safety of the Cytosponge-trefoil factor 3, a cell collection device coupled with the biomarker trefoil…”
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Predictors of the experience of a Cytosponge test: analysis of patient survey data from the BEST3 trial by Ghimire, Bhagabati, Landy, Rebecca, Maroni, Roberta, Smith, Samuel G, Debiram-Beecham, Irene, Sasieni, Peter D, Fitzgerald, Rebecca C, Rubin, Greg, Walter, Fiona M, Waller, Jo, Offman, Judith

“…The Cytosponge is a cell-collection device, which, coupled with a test for trefoil factor 3 (TFF3), can be used to diagnose Barrett's oesophagus, a precursor…”
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Use of a non-endoscopic immunocytological device (Cytosponge™) for post chemoradiotherapy surveillance in patients with oesophageal cancer in the UK (CYTOFLOC): A multicentre feasibility study by Jones, Christopher M, O'Connor, Heather, O'Donovan, Maria, Hayward, Daniel, Blasko, Adrienn, Harman, Ruth, Malhotra, Shalini, Debiram-Beecham, Irene, Alias, Bincy, Bailey, Adam, Bateman, Andrew, Crosby, Tom D L, Falk, Stephen, Gollins, Simon, Hawkins, Maria A, Kadri, Sudarshan, Levy, Stephanie, Radhakrishna, Ganesh, Roy, Rajarshi, Sripadam, Raj, Fitzgerald, Rebecca C, Mukherjee, Somnath

“…Effective surveillance strategies are required for patients diagnosed with oesophageal squamous cell carcinoma (OSCC) or adenocarcinoma (OAC) for whom…”
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Breath Biopsy Assessment of Liver Disease Using an Exogenous Volatile Organic Compound—Toward Improved Detection of Liver Impairment by Ferrandino, Giuseppe, Orf, Isabel, Smith, Rob, Calcagno, Marzia, Thind, Anita Kaur, Debiram-Beecham, Irene, Williams, Megan, Gandelman, Olga, de Saedeleer, Alexandra, Kibble, Graham, Lydon, Anne Marie, Mayhew, Chris A., Allsworth, Max, Boyle, Billy, van der Schee, Marc P., Allison, Michael, Hoare, Matthew, Snowdon, Victoria K.

“…Liver cirrhosis and its complication - hepatocellular carcinoma (HCC) - have been associated with increased exhaled limonene. It is currently unclear whether…”
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Range of pathologies diagnosed using a minimally invasive capsule sponge to evaluate patients with reflux symptoms by Paterson, Anna L, Lao‐Sirieix, Pierre, O'Donovan, Maria, Debiram‐Beecham, Irene, Pietro, Massimiliano, Miremadi, Ahmad, Attwood, Stephen E, Walter, Fiona M, Sasieni, Peter D, Fitzgerald, Rebecca C

“…Aims Reflux symptoms are highly prevalent and non‐specific; hence, in the absence of alarm symptoms, endoscopy referral decisions are challenging. This study…”
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Accuracy, Safety, and Tolerability of Tissue Collection by Cytosponge vs Endoscopy for Evaluation of Eosinophilic Esophagitis by Katzka, David A, Geno, Debra M, Ravi, Anupama, Smyrk, Thomas C, Lao-Sirieix, Pierre, Miramedi, Ahmed, Debiram, Irene, O’Donovan, Maria, Kita, Hirohito, Kephart, Gail M, Kryzer, Lori A, Camilleri, Michael, Alexander, Jeffrey A, Fitzgerald, Rebecca C

“…Background & Aims Management of eosinophilic esophagitis (EoE) requires repeated endoscopic collection of mucosal samples to assess disease activity and…”
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Cytosponge-TFF3 Testing can Detect Precancerous Mucosal Changes of the Stomach by Hadjinicolaou, ANDREAS V., Azizi, ALEXANDER A., O’Donovan, MARIA, Debiram, IRENE, Fitzgerald, REBECCA C., Di Pietro, MASSIMILIANO

“…Gastric intestinal metaplasia (GIM) and gastric atrophy (GA) are associated with increased risk of gastric cancer and are indications for endoscopic…”
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Acceptability and accuracy of a non-endoscopic screening test for Barrett’s oesophagus in primary care: cohort study by Kadri, Sudarshan R, Lao-Sirieix, Pierre, O’Donovan, Maria, Debiram, Irene, Das, Madhumita, Blazeby, Jane M, Emery, Jon, Boussioutas, Alex, Morris, Helen, Walter, Fiona M, Pharoah, Paul, Hardwick, Richard H, Fitzgerald, Rebecca C

“…Objectives To determine the accuracy and acceptability to patients of non-endoscopic screening for Barrett’s oesophagus, using an ingestible oesophageal…”
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Sa1643 - Feasibility of the Implementation of Cytosponge as a Triage Test for Reflux Symptoms in Primary Care: Barrett's Esophagus Screening Trial 3 (Best3) by Wilson, Ashley, -Beecham, Irene Debiram, Bowers, Ben, Muldrew, Beth, Aigret, Benoit, O'Donovan, Maria, Tripathi, Monika, Offman, Judith, Smith, Sam, Jackson, Chris, Pesola, Francesca, Kaimi, Irene, Haynes, Beverley, Walter, Fiona, Rubin, Greg, Morris, Stephen, Sasieni, Peter, Fitzgerald, Rebecca C.

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Methylation panel is a diagnostic biomarker for Barrett's oesophagus in endoscopic biopsies and non-endoscopic cytology specimens by Chettouh, Hamza, Mowforth, Oliver, Galeano-Dalmau, Núria, Bezawada, Navya, Ross-Innes, Caryn, MacRae, Shona, Debiram-Beecham, Irene, O'Donovan, Maria, Fitzgerald, Rebecca C

“…Barrett's oesophagus is a premalignant condition that occurs in the context of gastro-oesophageal reflux. However, most Barrett's cases are undiagnosed because…”
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Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial by Muldrew, Beth, Gehrung, Marcel, Tripathi, Monika, Smith, Samuel G, Muddu, Ajay, Northrop, Alex, Shiner, Alice, Takhar, Amrit, Jarman, Andrea, Wong, Angela, Gibbons, Anita, Lalonde, Anna, Lee, Arlene, Wilson, Ashley, Donepudi, Balaji, Coghill, Ben, de Quadros, Bruno, Bratten, Carla, Brown, Carly, Moorbey, Chantelle, Clisby, Charles, Gordon, Charles, Castle, Chris, Newark, Chris, Norris, Chrissie, A'Court, Christine, Graham, Claire, Rees, Colin, Paschalides, Costas, Morris, Danielle, Hagan, Daryl, Cronk, David, Phillips, Dean, Kejariwal, Deepak, Adams, Fran, Pesola, Francesca, Forbes, Gareth, Collins, Glenn, Irvine, Gordon, Fourie, Gysbert, Doyle, Harriet, Bowyer, Helen, Modelell, Ines, Emmerson, Ingrid, Ortiz, Jacobo, Johnson, Jenny, Ducker, Jill, Skinner, Jo, Dash, Joanne, Miralles, Jose, Ridgway, Josephine, Ince, Julia, Milne, Kate, Baseley, Laura, Lovat, Laurence, Berney, Lee, Westwood, Lisa, Leggett, Loraine, Scovell, Louise, Saunders, Lucy, Baldry, Marie, Macedo, Mario, Attah, Mark, Wallard, Matthew, Penacerrada, Melchizedek, Baker-Moffatt, Michelle, Brewer, Nick, Todd, Nicky, Zolle, Olga, Ojechi, Patrick, Banim, Paul, Spellar, Paula, Bhandari, Pradeep, Kant, Prashant, Nixon, Rachel, Russell, Rebecca, Skule, Rene, Fox, Robin, Bastiman, Sally, Warburton, Samantha, Leith-Russell, Sarah, Utting, Sarah, Wytrykowski, Sarah, Malhotra, Shalini, Woods, Sharon, Conway, Shaun, Macrae, Shona, Singh, Shruti, Fourie, Simona, Campbell, Siobhan, Goel, Sonica, Jones, Stephen, Knight, Steve, Allen, Sue, Leighton, Theresa, Bray, Tim, Santosh, Vanaja, Briggs, William, Khan, Zohrah, Sasieni, Peter

“…Treatment of dysplastic Barrett's oesophagus prevents progression to adenocarcinoma; however, the optimal diagnostic strategy for Barrett's oesophagus is…”
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Use of a Cytosponge biomarker panel to prioritise endoscopic Barrett's oesophagus surveillance: a cross-sectional study followed by a real-world prospective pilot by Pilonis, Nastazja Dagny, Killcoyne, Sarah, Tan, W Keith, O'Donovan, Maria, Malhotra, Shalini, Tripathi, Monika, Miremadi, Ahmad, Debiram-Beecham, Irene, Evans, Tara, Phillips, Rosemary, Morris, Danielle L, Vickery, Craig, Harrison, Jon, di Pietro, Massimiliano, Ortiz-Fernandez-Sordo, Jacobo, Haidry, Rehan, Kerridge, Abigail, Sasieni, Peter D, Fitzgerald, Rebecca C

“…Endoscopic surveillance is recommended for patients with Barrett's oesophagus because, although the progression risk is low, endoscopic intervention is highly…”
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Safety and Acceptability of Esophageal Cytosponge Cell Collection Device in a Pooled Analysis of Data From Individual Patients by Januszewicz, Wladyslaw, Tan, Wei Keith, Lehovsky, Katie, Debiram-Beecham, Irene, Nuckcheddy, Tara, Moist, Susan, Kadri, Sudarshan, di Pietro, Massimiliano, Boussioutas, Alex, Shaheen, Nicholas J., Katzka, David A., Dellon, Evan S., Fitzgerald, Rebecca C.

“…Diagnosis and surveillance of Barrett’s esophagus (BE) and eosinophilic esophagitis (EoE) have become emerging public health issues. Cytosponge is a novel,…”
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Bone structure and remodelling in stroke patients: Early effects of zoledronate by Poole, Kenneth E.S, Vedi, Shobna, Debiram, Irene, Rose, Collette, Power, Jon, Loveridge, Nigel, Warburton, Elizabeth A, Reeve, Jonathan, Compston, Juliet

“…Abstract Introduction We have reported that after an acute stroke, intravenous zoledronate prevented bone loss in the hemiplegic hip. Participants from the…”
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Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma by Noorani, Ayesha, Li, Xiaodun, Goddard, Martin, Crawte, Jason, Alexandrov, Ludmil B., Secrier, Maria, Eldridge, Matthew D., Bower, Lawrence, Weaver, Jamie, Lao-Sirieix, Pierre, Martincorena, Inigo, Debiram-Beecham, Irene, Grehan, Nicola, MacRae, Shona, Malhotra, Shalini, Miremadi, Ahmad, Thomas, Tabitha, Galbraith, Sarah, Petersen, Lorraine, Preston, Stephen D., Gilligan, David, Hindmarsh, Andrew, Hardwick, Richard H., Stratton, Michael R., Wedge, David C., Fitzgerald, Rebecca C.

“…The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread. Whole-genome sequencing and…”
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Targeted Screening for Barrett’s Esophagus and Esophageal Cancer: Post Hoc Analysis From the Randomized BEST3 Trial by Tan, W. Keith, Maroni, Roberta, Offman, Judith, Zamani, Shahriar A., di Pietro, Massimiliano, O’Donovan, Maria, Muldrew, Beth, Debiram-Beecham, Irene, Gehrung, Marcel, Tripathi, Monika, Smith, Samuel G., Aigret, Benoit, Walter, Fiona M., Rubin, Greg, Sasieni, Peter D., Fitzgerald, Rebecca C.

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