Search Results - "Debiasio, Richard"

A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate by Bircsak, Kristin M., DeBiasio, Richard, Miedel, Mark, Alsebahi, Alaa, Reddinger, Ryan, Saleh, Anthony, Shun, Tongying, Vernetti, Lawrence A., Gough, Albert

“…We report the development, automation and validation of a 3D, microfluidic liver-on-a-chip for high throughput hepatotoxicity screening, the OrganoPlate…”
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A human liver microphysiology platform for investigating physiology, drug safety, and disease models by Vernetti, Lawrence A, Senutovitch, Nina, Boltz, Robert, DeBiasio, Richard, Ying Shun, Tong, Gough, Albert, Taylor, D Lansing

“…This paper describes the development and characterization of a microphysiology platform for drug safety and efficacy in liver models of disease that includes a…”
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In vitro platforms for evaluating liver toxicity by Bale, Shyam Sundhar, Vernetti, Lawrence, Senutovitch, Nina, Jindal, Rohit, Hegde, Manjunath, Gough, Albert, McCarty, William J, Bakan, Ahmet, Bhushan, Abhinav, Shun, Tong Ying, Golberg, Inna, DeBiasio, Richard, Usta, Berk Osman, Taylor, D Lansing, Yarmush, Martin L

“…The liver is a heterogeneous organ with many vital functions, including metabolism of pharmaceutical drugs and is highly susceptible to injury from these…”
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A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system by Aleman, Julio, K, Ravikumar, Wiegand, Connor, Schurdak, Mark E., Vernetti, Lawrence, Gavlock, Dillon, Reese, Celeste, DeBiasio, Richard, LaRocca, Greg, Angarita, Yulder Daniel, Gough, Albert, Soto-Gutierrez, Alejandro, Behari, Jaideep, Yechoor, Vijay K., Miedel, Mark T., Stern, Andrew M., Banerjee, Ipsita, Taylor, D. Lansing

“…Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in islets,…”
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High-Throughput Liver-ON-A-Chip for predictive hepatotoxicity screening by Saleh, Anthony, DeBiasio, Richard, Wilschut, Karlijn, Vernetti, Lawrence, Taylor, D. Lansing, Vulto, Paul, Gough, Albert, Sharma, Anup

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Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy by Xia, Mengying, Varmazyad, Mahboubeh, Pla-Palacín, Iris, Gavlock, Dillon C, DeBiasio, Richard, LaRocca, Gregory, Reese, Celeste, Florentino, Rodrigo M, Faccioli, Lanuza A P, Brown, Jacquelyn A, Vernetti, Lawrence A, Schurdak, Mark, Stern, Andrew M, Gough, Albert, Behari, Jaideep, Soto-Gutierrez, Alejandro, Taylor, D Lansing, Miedel, Mark T

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide health epidemic with a global occurrence of approximately 30%. The pathogenesis…”
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A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies by Lefever, Daniel E, Miedel, Mark T, Pei, Fen, DiStefano, Johanna K, Debiasio, Richard, Shun, Tong Ying, Saydmohammed, Manush, Chikina, Maria, Vernetti, Lawrence A, Soto-Gutierrez, Alejandro, Monga, Satdarshan P, Bataller, Ramon, Behari, Jaideep, Yechoor, Vijay K, Bahar, Ivet, Gough, Albert, Stern, Andrew M, Taylor, D Lansing

“…Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence with a heterogeneous and complex pathophysiology that presents barriers to traditional…”
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Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems by Lee-Montiel, Felipe T, George, Subin M, Gough, Albert H, Sharma, Anup D, Wu, Juanfang, DeBiasio, Richard, Vernetti, Lawrence A, Taylor, D Lansing

“…This article describes our next generation human Liver Acinus MicroPhysiology System (LAMPS). The key demonstration of this study was that Zone 1 and Zone 3…”
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Fluorescent protein biosensors applied to microphysiological systems by Senutovitch, Nina, Vernetti, Lawrence, Boltz, Robert, DeBiasio, Richard, Gough, Albert, Taylor, D Lansing

“…This mini-review discusses the evolution of fluorescence as a tool to study living cells and tissues in vitro and the present role of fluorescent protein…”
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Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors by Saydmohammed, Manush, Jha, Anupma, Mahajan, Vineet, Gavlock, Dillon, Shun, Tong Ying, DeBiasio, Richard, Lefever, Daniel, Li, Xiang, Reese, Celeste, Kershaw, Erin E, Yechoor, Vijay, Behari, Jaideep, Soto-Gutierrez, Alejandro, Vernetti, Larry, Stern, Andrew, Gough, Albert, Miedel, Mark T, Lansing Taylor, D

“…Metabolic syndrome is a complex disease that involves multiple organ systems including a critical role for the liver. Non-alcoholic fatty liver disease (NAFLD)…”
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Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans by Bhushan, Abhinav, Senutovitch, Nina, Bale, Shyam S, McCarty, William J, Hegde, Manjunath, Jindal, Rohit, Golberg, Inna, Berk Usta, O, Yarmush, Martin L, Vernetti, Lawrence, Gough, Albert, Bakan, Ahmet, Shun, Tong Ying, DeBiasio, Richard, Lansing Taylor, D

“…Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to…”
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Quantitative cell-based high-content screening for vasopressin receptor agonists using transfluor technology by Ghosh, Richik N, DeBiasio, Richard, Hudson, Christine C, Ramer, Everett R, Cowan, Conrad L, Oakley, Robert H

“…The authors demonstrate the use of a simple, universal G-protein-coupled receptor (GPCR) assay to screen for agonists for a specific GPCR. Cells stably…”
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