Search Results - "Debernardis, J F"

Multicenter assessment of CSF-phosphorylated tau for the prediction of conversion of MCI by EWERS, M, BUERGER, K, WALLIN, A, DEBERNARDIS, J. F, KERKMAN, D. J, HEINDL, B, BLENNOW, K, HAMPEL, H, TEIPEL, S. J, SCHELTENS, P, SCHRÖDER, J, ZINKOWSKI, R. P, BOUWMAN, F. H, SCHÖNKNECHT, P, SCHOONENBOOM, N. S. M, ANDREASEN, N

“…The measurement of hyperphosphorylated tau (p-tau) in CSF has been proposed as a biomarker candidate for the prediction of Alzheimer disease (AD) in patients…”
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A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype by Knepper, S M, Buckner, S A, Brune, M E, DeBernardis, J F, Meyer, M D, Hancock, A A

“…N-[5-(4,5-dihydro-1H-imidazol-2yl)-2-hydroxy-5,6,7,8-tetrahydro naphthalen-1-yl] methanesulfonamide hydrobromide (A-61603) is a novel and potent…”
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Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism by Leeb-Lundberg, L M, Cotecchia, S, Lomasney, J W, DeBernardis, J F, Lefkowitz, R J, Caron, M G

“…DDT1 MF-2 cells, which are derived from hamster vas deferens smooth muscle, contain alpha 1-adrenergic receptors (54,800 +/- 2700 sites per cell) that are…”
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Discovery of a novel class of orally active, non-peptide angiotensin II antagonists by De, B, Winn, M, Zydowsky, T. M, Kerkman, D. J, DeBernardis, J. F, Lee, J, Buckner, S, Warner, R, Brune, M

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Actions of A-75200, a novel catecholamine uptake inhibitor, on norepinephrine uptake and release from bovine adrenal chromaffin cells by Firestone, J A, Gerhardt, G A, DeBernardis, J F, McKelvy, J F, Browning, M D

“…The balance between catecholamine (CA) release and reuptake is closely regulated and determines the effective level of transmitter at the synaptic cleft. Drugs…”
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Characterization of antihypertensive activity of ABBOTT-81988, a nonpeptide angiotensin II antagonist in the renal hypertensive rat by Lee, J Y, Buckner, S A, Brune, M E, Warner, R B, Winn, M, De, B, Zydowsky, T M, Opgenorth, T J, Kerkman, D J, Debernardis, J F

“…2-(N-Propyl-N[(2'-[1H-tetrazol-5-yl]biphenyl-4yl)methyl]amin o) pyridine-3-carboxylic acid (ABBOTT-81988), a novel nonpeptide angiotensin II (AII) antagonist,…”
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Preclinical pharmacological actions of (+/-)-(1'R,3R)-3-phenyl-1- [1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic receptors and inhibits the neuronal uptake of norepinephrine by Hancock, A A, Buckner, S A, Giardina, W J, Brune, M E, Lee, J Y, Morse, P A, Oheim, K W, Stanisic, D S, Warner, R B, Kerkman, D J

“…(+/-)-(1'R*,3R*)-3-phenyl-1-[(1',2',3',4'-tetrahydro-5',6'-methylene- dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) was evaluated in a…”
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Discovery of potential antidepressant agents: Novel 3-arylpyrrolidines with dual mechanism of action on neurotransmission by Basha, Fatima Z., DeBernardis, J. F.

“…Abstract…”
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Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit by Lomasney, J W, Leeb-Lundberg, L M, Cotecchia, S, Regan, J W, DeBernardis, J F, Caron, M G, Lefkowitz, R J

“…alpha 1-Adrenergic receptors from a cultured smooth muscle cell line (DDT1 MF-2) have been solubilized with digitonin and purified to apparent homogeneity by…”
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Evaluation of the side arm of (naphthylvinyl)pyridinium inhibitors of choline acetyltransferase by DeBernardis, J. F, Gifford, P, Rizk, M, Ertel, R, Abraham, D. J, Siuda, J. F

“…A number of quaternary salts of trans-4-(beta-1-naphthylvinyl)pyridine (NVP) were synthesized and evaluated as inhibitors of the enzymes choline…”
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Antihypertensive activity of ABBOTT-81282, a nonpeptide angiotensin II antagonist, in the renal hypertensive rat by Lee, J Y, Brune, M E, Warner, R B, Buckner, S B, Winn, M, De, B, Zydowsky, T M, Opgenorth, T J, Kerkman, D J, DeBernardis, J F

“…ABBOTT-81282, 4-(N-butyl-N-[(2-'-[1H-tetrazol-5yl]biphenyl-4-yl)methyl]ami no) pyrimidine-5-carboxylic acid is a novel nonpeptide angiotensin II (AII)…”
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Cardiovascular effects of orally administered ABBOTT-81988, an angiotensin II antagonist, in conscious spontaneously hypertensive rats by Lee, J Y, Warner, R B, Brune, M E, Adler, A L, Winn, M, De, B, Zydowsky, T M, Opgenorth, T J, Kerkman, D J, DeBernardis, J F

“…ABBOTT-81988 (A-81988), 2-(N-propyl-N[(2'-[1H-tetrazol-5-yl]biphenyl- 4yl)methyl] amino) pyridine-3-carboxylic acid, a nonpeptide angiotensin II (AII)…”
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Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe by Leeb-Lundberg, L M, Dickinson, K E, Heald, S L, Wikberg, J E, Hagen, P O, DeBernardis, J F, Winn, M, Arendsen, D L, Lefkowitz, R J, Caron, M G

“…We have synthesized and characterized a novel high affinity radioiodinated alpha 1-adrenergic receptor photoaffinity probe,…”
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Phorbol Esters Promote α1-adrenergic Receptor Phosphorylation and Receptor Uncoupling from Inositol Phospholipid Metabolism by L. M. Fredrik Leeb-Lundberg, Cotecchia, Susanna, Lomasney, Jon W., DeBernardis, John F., Lefkowitz, Robert J., Caron, Marc G.

“…DDT1MF-2 cells, which are derived from hamster vas deferens smooth muscle, contain α1-adrenergic receptors (54,800 ± 2700 sites per cell) that are coupled to…”
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Molecular design of novel ligands for 5-HT1A receptors by Hancock, A A, Meyer, M D, DeBernardis, J F

“…Serotonin (5-HT) is a potent bioactive substance known to function through a number of different receptor types and subtypes. In our attempt to develop new…”
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A new nasal decongestant, A-57219: a comparison with oxymetazoline by DeBernardis, J F, Winn, M, Kerkman, D J, Kyncl, J J, Buckner, S, Horrom, B

“…2-(4-Amino-3,5-dichlorobenzyl)imidazoline hydrochloride (A-57219), has alpha 1-agonist/alpha 2-antagonist activity and was more effective and long-acting than…”
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Adrenergic and dopaminergic properties of dopamine sulfoconjugates by Kyncl, J J, Buckner, S A, Brondyk, H, Kerkman, D J, DeBernardis, J F, Bush, E N, Kuchel, O

“…The 3- and 4-sulfate esters of dopamine (DA-3-SO4 and DA-4-SO4, respectively), the two main metabolites of DA, were evaluated for potential intrinsic or…”
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Structural correlations of choline acetyltransferase inhibitors: trans-N-(carboxymethyl)-4-(.beta.-1-naphthylvinyl)pyridinium bromide and cis-N-(2-aminoethyl)-4-(.beta.-1-naphthylvinyl)-3-methylpyridinium bromide hydrobromide by Chweh, Andrew Y, DeBernardis, John F, Siuda, Jerome F, Rondan, Nelson G, Abola, Jaime E, Abraham, Donald J

“…This paper correlates the X-ray structures of two 4-(beta-1-naphthylvinyl)pyridine analogues (one cis and one trans) with chemical and biological activity data…”
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Similarity of central and peripheral alpha-1 adrenoceptors in rat and rabbit by Bush, E N, Walker, D E, Stanisic, D, DeBernardis, J F, Kyncl, J J

“…In order to examine species and tissue differences in alpha 1 adrenoceptors, binding experiments were performed using 3H-prazosin and membrane homogenates of…”
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Calcium-induced vasocontractions after alpha-2 adrenergic receptor activation in the dog saphenous vein: comparison to calcium-induced contractions after potassium-depolarization by Lee, J Y, Warner, R B, Brune, M E, DeBernardis, J F

“…1. Calcium mediated contractile effects were evoked in phenoxybenzamine (10(-7) M)-pretreated dog saphenous vein (DSV) rings under the continuing presence of…”
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