Search Results - "Debeissat, Christelle"

Flow cytometric quantification of all phases of the cell cycle and apoptosis in a two-color fluorescence plot by Vignon, Christine, Debeissat, Christelle, Georget, Marie-Thérèse, Bouscary, Didier, Gyan, Emmanuel, Rosset, Philippe, Herault, Olivier

“…An optimal technology for cell cycle analysis would allow the concomitant measurement of apoptosis, G0, G1, S, G2 and M phases in combination with cell surface…”
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Characteristics of cells with engraftment capacity within CD34+ cell population upon G-CSF and Plerixafor mobilization by Mombled, Margaux, Rodriguez, Laura, Avalon, Maryse, Duchez, Pascale, Vlaski-Lafarge, Marija, Debeissat, Christelle, Pérard, Baptiste, Sawai, Katherine M., Pasquet, Jean Max, Bijou, Fontanet, Thévenot, Florian, Cabantous, Txomin, Ivanovic, Zoran, Brunet de la Grange, Philippe

“…In the context of hematopoietic cell transplantation, hematopoietic stem cells and progenitor cells (HSC and HPC) are usually collected by apheresis following…”
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Involvement of GPx-3 in the Reciprocal Control of Redox Metabolism in the Leukemic Niche by Vignon, Christine, Debeissat, Christelle, Bourgeais, Jérôme, Gallay, Nathalie, Kouzi, Farah, Anginot, Adrienne, Picou, Frédéric, Guardiola, Philippe, Ducrocq, Elfi, Foucault, Amélie, Ravalet, Noémie, Le Nail, Louis-Romée, Domenech, Jorge, Béné, Marie-Christine, Le Bousse-Kerdilès, Marie-Caroline, Gyan, Emmanuel, Herault, Olivier

“…The bone marrow (BM) microenvironment plays a crucial role in the development and progression of leukemia (AML). Intracellular reactive oxygen species (ROS)…”
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Regulatory Crosstalk between Physiological Low O2 Concentration and Notch Pathway in Early Erythropoiesis by Labat, Véronique, Bayard, Eva Nguyen van Thanh dit, Refeyton, Alice, Huart, Mathilde, Avalon, Maryse, Debeissat, Christelle, Rodriguez, Laura, de la Grange, Philippe Brunet, Ivanovic, Zoran, Vlaski-Lafarge, Marija

“…Physiological low oxygen (O2) concentration (<5%) favors erythroid development ex vivo. It is known that low O2 concentration, via the stabilization of…”
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Alpha Lipoic-Acid Potentiates Ex Vivo Expansion of Human Steady-State Peripheral Blood Hematopoietic Primitive Cells by Debeissat, Christelle, Avalon, Maryse, Huart, Mathilde, Duchez, Pascale, Rodriguez, Laura, Vlaski-Lafarge, Marija, Ivanovic, Zoran, Brunet de la Grange, Philippe

“…Steady state peripheral blood (SSPB) contains hematopoietic stem and progenitor cells (HSPCs) presenting characteristics of real hematopoietic stem cells, and…”
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Bone marrow oxidative stress and specific antioxidant signatures in myelodysplastic syndromes by Picou, Frederic, Vignon, Christine, Debeissat, Christelle, Lachot, Sébastien, Kosmider, Olivier, Gallay, Nathalie, Foucault, Amelie, Estienne, Marie-Hélène, Ravalet, Noémie, Bene, Marie C., Domenech, Jorge, Gyan, Emmanuel, Fontenay, Michaela, Herault, Olivier

“…Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders with an inherent tendency for transformation in secondary acute myeloid…”
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α-Tocopherol Attenuates Oxidative Phosphorylation of CD34 + Cells, Enhances Their G0 Phase Fraction and Promotes Hematopoietic Stem and Primitive Progenitor Cell Maintenance by Rodriguez, Laura, Duchez, Pascale, Touya, Nicolas, Debeissat, Christelle, Guitart, Amélie V, Pasquet, Jean-Max, Vlaski-Lafarge, Marija, Brunet de la Grange, Philippe, Ivanovic, Zoran

“…Alpha tocopherol acetate (αTOA) is an analogue of alpha tocopherol (αTOC) that exists in the form of an injectable drug. In the context of the metabolic…”
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Characterization of NADPH Oxidase Expression and Activity in Acute Myeloid Leukemia Cell Lines: A Correlation with the Differentiation Status by Dakik, Hassan, El Dor, Maya, Leclerc, Joan, Kouzi, Farah, Nehme, Ali, Deynoux, Margaux, Debeissat, Christelle, Khamis, Georges, Ducrocq, Elfi, Ibrik, Aida, Stasia, Marie-José, Raad, Houssam, Rezvani, Hamid Reza, Gouilleux, Fabrice, Zibara, Kazem, Herault, Olivier, Mazurier, Frédéric

“…In acute myeloid leukemia (AML), a low level of reactive oxygen species (ROS) is associated with leukemic stem cell (LSC) quiescence, whereas a high level…”
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Expression of miRNA-210 in human bone marrow-derived mesenchymal stromal cells under oxygen deprivation by Loncaric, Darija, Stankovic, Biljana, Ghousein, Amani, Vreca, Misa, Spasovski, Vesna, Villacreces, Arnaud, Debeissat, Christelle, Grosset, Christophe, Ivanovic, Zoran, Pavlovic, Sonja

“…A major limitation in the development of efficient clinical protocols for mesenchymal stromal cell (MStroC)-based tissue regeneration therapy is the low…”
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Interleukin-6 (IL-6) and low O2 concentration (1%) synergize to improve the maintenance of hematopoietic stem cells (pre-CFC) by Kovačević-Filipović, Milica, Petakov, Marijana, Hermitte, Francis, Debeissat, Christelle, Krstić, Aleksandra, Jovčić, Gordana, Bugarski, Dijana, Lafarge, Xavier, Milenković, Pavle, Praloran, Vincent, Ivanović, Zoran

“…Low O2 concentration (1%) favors the self‐renewal of hematopoietic stem cells and inhibits committed progenitors (CFC). Since IL‐6 influences both stem cells…”
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Imaging of conditional gene silencing in vivo using a bioluminescence-based method with thermo-inducible microRNAs by Pinel, Karine, Genevois, Coralie, Debeissat, Christelle, Couillaud, Franck

“…RNA interference (RNAi)-based gene therapy has great potential in cancer and infectious disease treatment to correct abnormal up-regulation of gene expression…”
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n-3 Polyunsaturated fatty acids induce acute myeloid leukemia cell death associated with mitochondrial glycolytic switch and Nrf2 pathway activation by Picou, Frédéric, Debeissat, Christelle, Bourgeais, Jérôme, Gallay, Nathalie, Ferrié, Elise, Foucault, Amélie, Ravalet, Noémie, Maciejewski, Aurore, Vallet, Nicolas, Ducrocq, Elfi, Haddaoui, Lamya, Domenech, Jorge, Hérault, Olivier, Gyan, Emmanuel

“…[Display omitted] Acute Myeloid Leukemia (AML) remains a therapeutic challenge and improvements in chemotherapy are needed. n-3 polyunsaturated fatty acids…”
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Aberrant DNA methylation impacts HOX genes expression in bone marrow mesenchymal stromal cells of myelodysplastic syndromes and de novo acute myeloid leukemia by Roux, Benjamin, Picou, Frédéric, Debeissat, Christelle, Koubi, Myriam, Gallay, Nathalie, Hirsch, Pierre, Ravalet, Noémie, Béné, Marie C., Maigre, Michel, Hunault, Mathilde, Mosser, Jean, Etcheverry, Amandine, Gyan, Emmanuel, Delhommeau, François, Domenech, Jorge, Herault, Olivier

“…DNA methylation, a major biological process regulating the transcription, contributes to the pathophysiology of hematologic malignancies, and hypomethylating…”
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GPx-3 Activity and Nrf2 Sub-Cellular Localization in Leukemic Cells Are Controlled by the Bone Marrow Niche by Herault, Olivier, Vignon, Christine, Debeissat, Christelle, Gyan, Emmanuel, Bonnin, Florence, Gouilleux, Fabrice, Domenech, Jorge, Mazurier, Frederic

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133 - GPx-3 Activity and Nrf2 Sub-Cellular Localization in Leukemic Cells Are Controlled by the Bone Marrow Niche by Herault, Olivier, Vignon, Christine, Debeissat, Christelle, Gyan, Emmanuel, Bonnin, Florence, Gouilleux, Fabrice, Domenech, Jorge, Mazurier, Frederic

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Abstract LB-334: The Nrf2-subcellular localization in human acute myeloblastic leukemic cells is regulated by the bone marrow mesenchymal stem/stromal cells by Herault, Olivier, Vignon, Christine, Debeissat, Christelle, Rouleux-Bonnin, Florence, Gyan, Emmanuel, Mazurier, Frederic, Gouilleux, Fabrice, Domenech, Jorge

“…Abstract BACKGROUND. The redox metabolism is a key actor in the pathophysiology of acute myeloblastic leukemia (AML). High level of reactive oxygen species…”
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Bioenergetic Changes Underline Plasticity of Murine Embryonic Stem Cells by Vlaski‐Lafarge, Marija, Loncaric, Darija, Perez, Laura, Labat, Véronique, Debeissat, Christelle, Brunet de la Grange, Philippe, Rossignol, Rodrigue, Ivanovic, Zoran, Bœuf, Hélène

“…Murine embryonic stem cells (mESCs) are endowed by a time‐dependent window of plasticity during their early commitment steps. Indeed, while mESCs deprived of…”
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α-Tocopherol Acetate Attenuates Mitochondrial Oxygen Consumption and Maintains Primitive Cells within Mesenchymal Stromal Cell Population by Loncaric, Darija, Rodriguez, Laura, Debeissat, Christelle, Touya, Nicolas, Labat, Veronique, Villacreces, Arnaud, Bouzier-Sore, Anne-Karine, Pasquet, Jean-Max, de la Grange, Philippe Brunet, Vlaski-Lafarge, Marija, Pavlovic, Sonja, Ivanovic, Zoran

“…We present here the data showing, in standard cultures exposed to atmospheric O concentration, that alpha-tocopherol acetate (α-TOA) has a positive impact on…”
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Steady state peripheral blood provides cells with functional and metabolic characteristics of real hematopoietic stem cells by Bourdieu, Antonin, Avalon, Maryse, Lapostolle, Véronique, Ismail, Sadek, Mombled, Margaux, Debeissat, Christelle, Guérinet, Marianne, Duchez, Pascale, Chevaleyre, Jean, Vlaski‐Lafarge, Marija, Villacreces, Arnaud, Praloran, Vincent, Ivanovic, Zoran, Brunet de la Grange, Philippe

“…Hematopoietic stem cells (HSCs), which are located in the bone marrow, also circulate in cord and peripheral blood. Despite high availability, HSCs from steady…”
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Docosahexaenoic Acid and Eicosapentaenoic Acid Are Keyplayers of the Cytotoxicity of a Parenteral Fish Oil Emulsion in Acute Myeloid Leukemia Cell Lines and Primary Blasts and This Effect Is Additive with Chemotherapy in Vitro by Gyan, Emmanuel, Debeissat, Christelle, Ducrocq, Elfi, Domenech, Jorge, Herault, Olivier

“…Abstract 2597 Acute Myeloid Leukemia (AML) represents a life-threatening myeloid malignancy for which standard chemotherapy remains the cornerstone of therapy…”
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