Search Results - "Deb, Gauri"

Plant Phytochemicals as Epigenetic Modulators: Role in Cancer Chemoprevention by Thakur, Vijay S., Deb, Gauri, Babcook, Melissa A., Gupta, Sanjay

“…In recent years, “nutri-epigenetics,” which focuses on the influence of dietary agents on epigenetic mechanism(s), has emerged as an exciting novel area in…”
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Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia by Deb, Gauri, Wingelhofer, Bettina, Amaral, Fabio M. R., Maiques-Diaz, Alba, Chadwick, John A., Spencer, Gary J., Williams, Emma L., Leong, Hui-Sun, Maes, Tamara, Somervaille, Tim C. P.

“…The histone demethylase lysine-specific demethylase 1 (LSD1 or KDM1A) has emerged as a candidate therapeutic target in acute myeloid leukaemia (AML);…”
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936 Stromal remodeling regulates dendritic cell abundance in the tumor microenvironment by Papadas, Athanasios, Deb, Gauri, Officer, Adam, Hope, Chelsea, Emmerich, Philip, Cicala, Alexander, Wiesner, Joshua, Arauz, Garrett, Pagenkopf, Adam, Matkowskyj, Kristina, Deming, Dustin, Politi, Katerina, Abrams, Scott, Harismendy, Olivier, Asimakopoulos, Fotis

“…BackgroundStimulatory dendritic cells (SDC), enriched within the Batf3-DC lineage (also known as conventional type 1 DC, cDC1), engage in productive…”
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Expression profiling of genes modulated by estrogen, EGCG or both in MCF-7 breast cancer cells by Manjegowda, Mohan C., Deb, Gauri, Kumar, Neeraj, Limaye, Anil M.

“…(−)-Epigallocatechin-3-gallate (EGCG) is one of the most potent and the most studied green tea catechin. Reports on mechanisms of EGCG action and its cellular…”
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Data in support of the negative influence of divalent cations on (−)-epigallocatechin-3-gallate (EGCG)-mediated inhibition of matrix metalloproteinase-2 (MMP-2) by Deb, Gauri, Batra, Sahil, Limaye, Anil M.

“…In this data article we have provided evidence for the negative influence of divalent cations on (−)‐epigallocatechin-3-gallate (EGCG)-mediated inhibition of…”
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EZH2: not EZHY (easy) to deal by Deb, Gauri, Singh, Anup Kumar, Gupta, Sanjay

“…Seminal discoveries have established that epigenetic modifications are important for driving tumor progression. Polycomb group (PcG) proteins are highly…”
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Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells by Deb, Gauri, Thakur, Vijay S., Limaye, Anil M., Gupta, Sanjay

“…Aberrant epigenetic silencing of the tissue inhibitor of matrix metalloproteinase‐3 (TIMP‐3) gene that negatively regulates matrix metalloproteinases (MMPs)…”
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Multifaceted role of EZH2 in breast and prostate tumorigenesis: Epigenetics and beyond by Deb, Gauri, Thakur, Vijay S., Gupta, Sanjay

“…Overexpression of EZH2 and other PRC2 subunits, such as SUZ12, is associated with tumor progression and poor prognosis in several human malignancies…”
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Green tea–induced epigenetic reactivation of tissue inhibitor of matrix metalloproteinase‐3 suppresses prostate cancer progression through histone‐modifying enzymes by Deb, Gauri, Shankar, Eswar, Thakur, Vijay S., Ponsky, Lee E., Bodner, Donald R., Fu, Pingfu, Gupta, Sanjay

“…Green tea polyphenols (GTPs) and their major constituent, epigallocatechin‐3‐gallate (EGCG), have been reported to demonstrate many interesting biological…”
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IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells by Lee, Jaewoong, Robinson, Mark E., Ma, Ning, Artadji, Dewan, Ahmed, Mohamed A., Xiao, Gang, Sadras, Teresa, Deb, Gauri, Winchester, Janet, Cosgun, Kadriye Nehir, Geng, Huimin, Chan, Lai N., Kume, Kohei, Miettinen, Teemu P., Zhang, Ye, Nix, Matthew A., Klemm, Lars, Chen, Chun Wei, Chen, Jianjun, Khairnar, Vishal, Wiita, Arun P., Thomas-Tikhonenko, Andrei, Farzan, Michael, Jung, Jae U., Weinstock, David M., Manalis, Scott R., Diamond, Michael S., Vaidehi, Nagarajan, Müschen, Markus

“…Interferon-induced transmembrane protein 3 (IFITM3) has previously been identified as an endosomal protein that blocks viral infection 1 – 3 . Here we studied…”
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Abstract 5084: Epigenetic modifications involving reactivation of RECK inhibiting MMP-9 and MMP-2 in prostate cancer by Shankar, Eswar, Iqbal, Omair, Bhaskaran, Natarajan, Deb, Gauri, MacLennan, Gregory T., Fu, Pingfu, Gupta, Sanjay

“…Abstract Metastasis is responsible for more than 90% of prostate cancer-associated mortality in the United States. One of the distinctive reason for metastasis…”
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Genome-Wide CRISPR-Cas9 Screen Identifies Sensitizers to LSD1 Inhibition in MLL-Translocated Human AML Cells by Deb, Gauri, Wingelhofer, Bettina, Williams, Emma, Leong, Hui-Sun, Somervaille, Tim CP

“…Lysine-specific demethylase (LSD1, also known as KDM1A) is an epigenetic regulator that has recently emerged as a potential therapeutic target in acute myeloid…”
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Signalling input from divergent pathways subverts B cell transformation by Chan, Lai N., Murakami, Mark A., Robinson, Mark E., Caeser, Rebecca, Sadras, Teresa, Lee, Jaewoong, Cosgun, Kadriye Nehir, Kume, Kohei, Khairnar, Vishal, Xiao, Gang, Ahmed, Mohamed A., Aghania, Eamon, Deb, Gauri, Hurtz, Christian, Shojaee, Seyedmehdi, Hong, Chao, Pölönen, Petri, Nix, Matthew A., Chen, Zhengshan, Chen, Chun Wei, Chen, Jianjun, Vogt, Andreas, Heinäniemi, Merja, Lohi, Olli, Wiita, Arun P., Izraeli, Shai, Geng, Huimin, Weinstock, David M., Müschen, Markus

“…Malignant transformation of cells typically involves several genetic lesions, whose combined activity gives rise to cancer 1 . Here we analyse 1,148…”
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Rationale for Targeting BCL6 in MLL-Rearranged B-ALL by Chan, Lai N, Hurtz, Christian, Geng, Huimin, Ballabio, Erica, Xiao, Gang, Deb, Gauri, Khoury, Haytham, Armstrong, Scott A., Ernst, Patricia, Melnick, Ari, Milne, Tom Arthur, Müschen, Markus

“…Background and significance:MLL-gene rearrangements occur in ~10% of B-cell acute lymphoblastic leukemia (B-ALL) and 70% of infant B-ALL and define a group of…”
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Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment by Papadas, Athanasios, Deb, Gauri, Cicala, Alexander, Officer, Adam, Hope, Chelsea, Pagenkopf, Adam, Flietner, Evan, Morrow, Zachary T., Emmerich, Philip, Wiesner, Joshua, Arauz, Garrett, Bansal, Varun, Esbona, Karla, Capitini, Christian M., Matkowskyj, Kristina A., Deming, Dustin A., Politi, Katerina, Abrams, Scott I., Harismendy, Olivier, Asimakopoulos, Fotis

“…Stimulatory type 1 conventional dendritic cells (cDC1s) engage in productive interactions with CD8+ effectors along tumor-stroma boundaries. The paradoxical…”
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Rationale for targeting BCL6 in MLL -rearranged acute lymphoblastic leukemia by Hurtz, Christian, Chan, Lai N, Geng, Huimin, Ballabio, Erica, Xiao, Gang, Deb, Gauri, Khoury, Haytham, Chen, Chun-Wei, Armstrong, Scott A, Chen, Jianjun, Ernst, Patricia, Melnick, Ari, Milne, Thomas, Müschen, Markus

“…Chromosomal rearrangements of the ( ) gene occur in ∼10% of B-cell acute lymphoblastic leukemia (B-ALL) and define a group of patients with dismal outcomes…”
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Abstract 253: Green tea polyphenol-mediated epigenetic reactivation of TIMP-3 reduces invasiveness and gelatinolytic activity in human breast cancer cells by Deb, Gauri, Thakur, Vijay S., Limaye, Anil M., Gupta, Sanjay

“…Abstract The molecular pathway from tumor development to clinically evident metastasis is complex and consists of multiple sequential steps. Substantial data…”
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Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies by Igoe, Niall, Bayle, Elliott D, Fedorov, Oleg, Tallant, Cynthia, Savitsky, Pavel, Rogers, Catherine, Owen, Dafydd R, Deb, Gauri, Somervaille, Tim C. P, Andrews, David M, Jones, Neil, Cheasty, Anne, Ryder, Hamish, Brennan, Paul E, Müller, Susanne, Knapp, Stefan, Fish, Paul V

“…The BRPF (bromodomain and PHD finger-containing) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family…”
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Abstract 2609: Epigenetic reactivation of TIMP-3 in human prostate cancer cells by green tea polyphenols by Deb, Gauri, Thakur, Vijay S., Shankar, Eswar, Gupta, Sanjay

“…Abstract Metastasis is responsible for more than 90% of prostate cancer-associated mortality in the United States. Metastasis is facilitated by remodeling of…”
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Abstract 5257: Upregulation of glutathione S-transferase P1 by green tea polyphenols: A novel transcriptional target of p53 tumor suppressor gene by Thakur, Vijay S., Deb, Gauri, Jackson, Mark W., Gupta, Sanjay

“…Abstract Green tea polyphenols (GTPs) and its major constituent (-)-epigallocatechin-3-gallate (EGCG) reactivate epigenetically silenced genes in cancer cells…”
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