Search Results - "Deaver, Daniel"

Sex differences and similarities in depressive- and anxiety-like behaviour in the Wistar-Kyoto rat by Burke, Nikita N, Coppinger, Jonathan, Deaver, Daniel R, Roche, Michelle, Finn, David P, Kelly, John

“…Abstract Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however,…”
Get full text

Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis by Keifer, Orion P, Gutierrez, Juanmarco, Butt, Mark T, Cramer, Sarah D, Bartus, Raymond, Tansey, Malu, Deaver, Daniel, Betourne, Alexandre, Boulis, Nicholas M

“…Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy is modest at…”
Get full text

Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates by Cunningham, Jacobi I, Eyerman, David J, Todtenkopf, Mark S, Dean, Reginald L, Deaver, Daniel R, Sanchez, Connie, Namchuk, Mark

“…Background: Olanzapine, regarded as one of the most efficacious antipsychotic medications for the treatment of schizophrenia, is associated with a high risk of…”
Get full text

Long-Acting Atypical Antipsychotics: Characterization of the Local Tissue Response by Paquette, Sara Montminy, Dawit, Had, Hickey, Magali B., Merisko-Liversidge, Elaine, Almarsson, Örn, Deaver, Daniel R.

“…Purpose Long-acting injectables (LAIs) are increasingly recognized as an effective therapeutic approach for treating chronic conditions. Many LAIs are…”
Get full text

Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat by Smith, Karen L., Cunningham, Jacobi I., Eyerman, David J., Dean, Reginald L., Deaver, Daniel R., Sanchez, Connie

“…Approximately two-thirds of major depressive disorder (MDD) patients do not respond adequately to current therapies. BUP/SAM (ALKS 5461), a combination of…”
Get full text

Antidepressant-like effects of 3-carboxamido seco-nalmefene (3CS-nalmefene), a novel opioid receptor modulator, in a rat IFN-α-induced depression model by Callaghan, Charlotte K., Rouine, Jennifer, Dean, Reginald L., Knapp, Brian I., Bidlack, Jean M., Deaver, Daniel R., O'Mara, Shane M.

“…•IFN-α treatment induced depressive-like and cognitive deficits in the rat.•IFN-α increased IL-6, IL-1β and corticosterone, and decreased neurogenesis and…”
Get full text

Samidorphan, an opioid receptor antagonist, attenuates drug-induced increases in extracellular dopamine concentrations and drug self-administration in male Wistar rats by Cunningham, Jacobi I., Todtenkopf, Mark S., Dean, Reginald L., Azar, Marc R., Koob, George F., Deaver, Daniel R., Eyerman, David J.

“…Opioid receptors modulate neurochemical and behavioral responses to drugs of abuse in nonclinical models. Samidorphan (SAM) is a new molecular entity that…”
Get full text

Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats by Burke, Nikita N., Ferdousi, Mehnaz, Deaver, Daniel R., Finn, David P., Roche, Michelle, Kelly, John P.

“…Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of…”
Get full text

Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats by Burke, Nikita N, Li, Yan, Deaver, Daniel R, Finn, David P, Roche, Michelle, Eyerman, David J, Sanchez, Connie, Kelly, John P

“…Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a…”
Get full text

Evaluation of samidorphan, a μ‐opioid antagonist, in a drug discrimination assay in rats by Sgro, Mario P., Modlin, Deah L., Deaver, Daniel R., Kallman, Mary J., Todtenkopf, Mark S.

“…Preclinical Research & Development Background: Samidorphan, a μ‐opioid receptor antagonist, is in clinical development for central nervous system related…”
Get full text

Large Porous Particles for Pulmonary Drug Delivery by Edwards, David A., Hanes, Justin, Caponetti, Giovanni, Hrkach, Jeffrey, Ben-Jebria, Abdelaziz, Eskew, Mary Lou, Mintzes, Jeffrey, Deaver, Daniel, Lotan, Noah, Langer, Robert

“…A new type of inhalation aerosol, characterized by particles of small mass density and large size, permitted the highly efficient delivery of inhaled…”
Get full text

Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats by Dean, Reginald L., Eyerman, David, Todtenkopf, Mark S., Turncliff, Ryan Z., Bidlack, Jean M., Deaver, Daniel R.

“…Naltrexone is a μ-opioid receptor antagonist that has been extensively studied for its ability to block the rewarding effects of ethanol. Opioid receptors are…”
Get full text

Effects of Extended-Release Injectable Naltrexone on Self-Injurious Behavior in Rhesus Macaques (Macaca mulatta) by Kempf, Doty J, Baker, Kate C, Gilbert, Margaret H, Blanchard, James L, Dean, Reginald L, Deaver, Daniel R, Bohm, Rudolf P

“…Self-injurious behavior (SIB) is a spontaneous behavior that threatens the health and wellbeing of multiple species. In humans, the opioid antagonist…”
Get full text

A new non-isotopic detection system for immunoassays by Deaver, Daniel R

Get full text

Naltrexone decreases D-amphetamine and ethanol self-administration in rhesus monkeys by Jimenez-Gomez, Corina, Winger, Gail, Dean, Reginald L, Deaver, Daniel R, Woods, James H

“…Amphetamines are the second most highly abused illicit drugs worldwide, yet there is no pharmacological treatment for amphetamine abuse and dependence…”
Get full text

Overriding the blockade of antinociceptive actions of opioids in rats treated with extended-release naltrexone by Dean, Reginald L., Todtenkopf, Mark S., Deaver, Daniel R., Arastu, Mahin F., Dong, Nan, Reitano, Krystal, O'Driscoll, Kevin, Kriksciukaite, Kristina, Gastfriend, David R.

“…A monthly extended-release formulation of the opioid antagonist naltrexone (XR-NTX) is approved for treatment of alcohol dependence. There is little research…”
Get full text

Myogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs by Draghia-Akli, R., Fiorotto, M. L., Hill, L. A., Malone, P. B., Deaver, D. R., Schwartz, R. J.

“…Ectopic expression of a new serum protease-resistant porcine growth hormone-releasing hormone, directed by an injectable muscle-specific synthetic promoter…”
Get full text

Route of administration affects the ability of naltrexone to reduce amphetamine-potentiated brain stimulation reward in rats by Todtenkopf, Mark S, O'Neill, Krystal S, Kriksciukaite, Kristina, Turncliff, Ryan Z, Dean, Reginald L, Ostrovsky-Day, Irina, Deaver, Daniel R

“…Opioid receptor antagonism has been shown to attenuate behavioral and neurochemical effects of amphetamine in humans and rodents. The effects of acute (oral or…”
Get full text

Growth hormone pulsatility profile characteristics following acute heavy resistance exercise by Nindl, Bradley C, Hymer, Wesley C, Deaver, Daniel R, Kraemer, William J

“…1  Intercollege Graduate Program in Physiology, 2  General Clinical Research Center at Noll Laboratory, 3  Department of Kinesiology, 4  Department of…”
Get full text

LH secretion and testosterone concentrations are blunted after resistance exercise in men by Nindl, Bradley C, Kraemer, William J, Deaver, Daniel R, Peters, Jana L, Marx, James O, Heckman, Jeffrey T, Loomis, Gregory A

“…1  Intercollege Graduate Program in Physiology, 2  General Clinical Research Center at Noll Laboratory, and Departments of 3  Kinesiology and 4  Animal…”
Get full text