Search Results - "Deaton, Rebecca A."

KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation by Bulut, Gamze B., Alencar, Gabriel F., Owsiany, Katherine M., Nguyen, Anh T., Karnewar, Santosh, Haskins, Ryan M., Waller, Lillian K., Cherepanova, Olga A., Deaton, Rebecca A., Shankman, Laura S., Keller, Susanna R., Owens, Gary K.

“…OBJECTIVE:Smooth muscle cells and pericytes display remarkable plasticity during injury and disease progression. Here, we tested the hypothesis that…”
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Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle by Deaton, Rebecca A, Gan, Qiong, Owens, Gary K

“…There is clear evidence that the phenotypic modulation of smooth muscle cells (SMCs) contributes to the pathophysiology of vascular disease. Phenotypic…”
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Oxidized Phospholipids Induce Phenotypic Switching of Vascular Smooth Muscle Cells In Vivo and In Vitro by Pidkovka, Nataliya A, Cherepanova, Olga A, Yoshida, Tadashi, Alexander, Matthew R, Deaton, Rebecca A, Thomas, James A, Leitinger, Norbert, Owens, Gary K

“…Atherosclerosis is a vascular disease characterized by lipid deposition and inflammation within the arterial wall. Oxidized phospholipids (oxPLs), such as…”
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Old bones control smooth muscle clones by Serbulea, Vlad, Deaton, Rebecca A, Owens, Gary K

“…Aging is known to exacerbate atherosclerosis, but the mechanisms have been largely unknown. A study in Nature Aging reveals a bone-marrow-controlled axis of…”
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PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns by Thomas, James A, Deaton, Rebecca A, Hastings, Nicole E, Shang, Yueting, Moehle, Christopher W, Eriksson, Ulf, Topouzis, Stavros, Wamhoff, Brian R, Blackman, Brett R, Owens, Gary K

“…Platelet-derived growth factor (PDGF)-BB is a well-known smooth muscle (SM) cell (SMC) phenotypic modulator that signals by binding to PDGF alphaalpha-,…”
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Response by Owens and Deaton to Letter Regarding Article, “Dichotomous Roles of Smooth Muscle Cell–Derived MCP1 (Monocyte Chemoattractant Protein 1) in Development of Atherosclerosis” by Owens, Gary K., Deaton, Rebecca A.

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A New Autosomal Myh11-CreERT2 Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model-Brief Report by Deaton, Rebecca A, Bulut, Gamze, Serbulea, Vlad, Salamon, Anita, Shankman, Laura S, Nguyen, Anh Tram, Owens, Gary K

“…BACKGROUNDThe Myh11 promoter is extensively used as a smooth muscle cell (SMC) Cre-driver and is regarded as the most restrictive and specific promoter…”
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Dichotomous Roles of Smooth Muscle Cell–Derived MCP1 (Monocyte Chemoattractant Protein 1) in Development of Atherosclerosis by Owsiany, Katherine M., Deaton, Rebecca A., Soohoo, Karen G., Tram Nguyen, Anh, Owens, Gary K.

“…Smooth muscle cells (SMCs) in atherosclerotic plaque take on multiple nonclassical phenotypes that may affect plaque stability and, therefore, the likelihood…”
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A New Autosomal Myh11-CreER T2 Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model—Brief Report by Deaton, Rebecca A., Bulut, Gamze, Serbulea, Vlad, Salamon, Anita, Shankman, Laura S., Nguyen, Anh Tram, Owens, Gary K.

“…The promoter is extensively used as a smooth muscle cell (SMC) Cre-driver and is regarded as the most restrictive and specific promoter available to study…”
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SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis by Hartmann, Felicia, Gorski, Daniel J., Newman, Alexandra A.C., Homann, Susanne, Petz, Anne, Owsiany, Katherine M., Serbulea, Vlad, Zhou, Yu-Qing, Deaton, Rebecca A., Bendeck, Michelle, Owens, Gary K., Fischer, Jens W.

“…[Figure: see text]…”
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Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition by Shamsuzzaman, Sohel, Deaton, Rebecca A, Salamon, Anita, Doviak, Heather, Serbulea, Vlad, Milosek, Victoria M, Evans, Megan A, Karnewar, Santosh, Saibaba, Subhi, Alencar, Gabriel F, Shankman, Laura S, Walsh, Kenneth, Bekiranov, Stefan, Kocher, Olivier, Krieger, Monty, Kull, Bengt, Persson, Marie, Michaëlsson, Erik, Bergenhem, Nils, Heydarkhan-Hagvall, Sepideh, Owens, Gary K

“…Thromboembolic events, including myocardial infarction (MI) or stroke, caused by the rupture or erosion of unstable atherosclerotic plaques are the leading…”
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IL-1β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice by Karnewar, Santosh, Karnewar, Vaishnavi, Deaton, Rebecca A, Shankman, Laura S, Benavente, Ernest D, Williams, Corey M, Bradley, Xenia, Alencar, Gabriel F, Bulut, Gamze B, Kirmani, Sara, Baylis, Richard A, Zunder, Eli R, den Ruijter, Hester M, Pasterkamp, Gerard, Owens, Gary K

“…Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions is the global leading cause of death. The most common and effective…”
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Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms by Newman, Alexandra A. C., Serbulea, Vlad, Baylis, Richard A., Shankman, Laura S., Bradley, Xenia, Alencar, Gabriel F., Owsiany, Katherine, Deaton, Rebecca A., Karnewar, Santosh, Shamsuzzaman, Sohel, Salamon, Anita, Reddy, Mahima S., Guo, Liang, Finn, Aloke, Virmani, Renu, Cherepanova, Olga A., Owens, Gary K.

“…Stable atherosclerotic plaques are characterized by a thick, extracellular matrix-rich fibrous cap populated by protective ACTA2 + myofibroblast (MF)-like…”
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Smooth muscle cell FTO regulates contractile function by Luse, Melissa A, Krüger, Nenja, Good, Miranda E, Biwer, Lauren A, Serbulea, Vlad, Salamon, Anita, Deaton, Rebecca A, Leitinger, Norbert, Gödecke, Axel, Isakson, Brant E

“…The fat mass and obesity gene (FTO) is a -methyladenosine RNA demethylase that was initially linked by Genome-wide association studies to increased rates of…”
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Transforming Growth Factor-β1-induced Expression of Smooth Muscle Marker Genes Involves Activation of PKN and p38 MAPK by Deaton, Rebecca A., Su, Chang, Valencia, Thomas G., Grant, Stephen R.

“…Differentiated vascular smooth muscle cells (SMCs) exhibit a work phenotype characterized by expression of several well documented contractile…”
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PKN Activation via Transforming Growth Factor-β1 (TGF-β1) Receptor Signaling Delays G2/M Phase Transition in Vascular Smooth Muscle Cells by Su, Chang, Deaton, Rebecca A., Iglewsky, Myriam A., Valencia, Thomas G., Grant, Stephen R.

“…The transition of vascular smooth muscle cells (VSMCs) from G2 phase into the M (mitosis) phase of the cell cycle is a tightly controlled process. As an…”
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Dichotomous Roles of Smooth Muscle Cell–Derived MCP1 (Monocyte Chemoattractant Protein 1) in Development of Atherosclerosis by Owens, Gary K., Deaton, Rebecca A.

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Altered smooth muscle cell phenotypic switching in atherogenesis and -progression in a murine model of chemically induced colitis by Prinz, Anika, Deaton, Rebecca A., Fischer, Jens, Owens, Gary K., Grandoch, Maria

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Dichotomous Roles of Smooth Muscle Cell–Derived MCP1 (Monocyte Chemoattractant Protein 1) in Development of Atherosclerosis by Owsiany, Katherine M., Deaton, Rebecca A., Soohoo, Karen G., Tram Nguyen, Anh, Owens, Gary K.

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A new autosomal Myh11-CreERT2 smooth muscle cell lineage tracing and gene knockout mouse model by Deaton, Rebecca A., Bulut, Gamze, Serbulea, Vlad, Salamon, Anita, Shankman, Laura S., Nguyen, Anh Tram, Owens, Gary K.

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