Search Results - "Deasy, J O"

Surface Reconstruction From Non-parallel Curve Networks by Liu, L., Bajaj, C., Deasy, J. O., Low, D. A., Ju, T.

“…Building surfaces from cross‐section curves has wide applications including bio‐medical modeling. Previous work in this area has mostly focused on connecting…”
Get full text

Multiple local minima in radiotherapy optimization problems with dose–volume constraints by Deasy, J. O.

“…The cause of multiple local minima in beam weight optimization problems subject to dose–volume constraints is analyzed. Three objective functions were…”
Get full text

Modelling the interplay between hypoxia and proliferation in radiotherapy tumour response by Jeong, J, Shoghi, K I, Deasy, J O

“…A tumour control probability computational model for fractionated radiotherapy was developed, with the goal of incorporating the fundamental interplay between…”
Get more information

“Primer shot” fractionation with an early treatment break is theoretically superior to consecutive weekday fractionation schemes for early-stage non-small cell lung cancer by Gouw, Z.A.R., Jeong, J., Rimner, A., Lee, N.Y., Jackson, A., Fu, A., Sonke, J-J., Deasy, J.O.

“…[Display omitted] •“Primer shot” is predicted to improve radiation efficacy for early stage NSCLC.•An early treatment break allows for reoxygenation,…”
Get full text

Exploring feature-based approaches in PET images for predicting cancer treatment outcomes by El Naqa, I., Grigsby, P.W., Apte, A., Kidd, E., Donnelly, E., Khullar, D., Chaudhari, S., Yang, D., Schmitt, M., Laforest, Richard, Thorstad, W.L., Deasy, J.O.

“…Accumulating evidence suggests that characteristics of pre-treatment FDG–PET could be used as prognostic factors to predict outcomes in different cancer sites…”
Get full text

A comparison of Monte Carlo dose calculation denoising techniques by El Naqa, I, Kawrakow, I, Fippel, M, Siebers, J V, Lindsay, P E, Wickerhauser, M V, Vicic, M, Zakarian, K, Kauffmann, N, Deasy, J O

“…Recent studies have demonstrated that Monte Carlo (MC) denoising techniques can reduce MC radiotherapy dose computation time significantly by preferentially…”
Get more information

Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy by Mackie, T R, Holmes, T, Swerdloff, S, Reckwerdt, P, Deasy, J O, Yang, J, Paliwal, B, Kinsella, T

“…Tomotherapy, literally "slice therapy," is a proposal for the delivery of radiation therapy with intensity-modulated strips of radiation. The proposed method…”
Get more information

SU‐C‐BRB‐06: Modeling Stereotactic Body Radiation Therapy (SBRT) including Cell Cycle‐Dependent Radiosensitivity, Hypoxia, Reoxygenation and Proliferation: Is SBRT Explainable Based on Classical Radiobiological Factors? by Jeong, J, Deasy, J O

“…Purpose: The tumoricidal effectiveness of standard fractionation radiotherapy is usually understood qualitatively in terms of proliferation, hypoxia, and…”
Get full text

A proton dose calculation algorithm for conformal therapy simulations based on Molière’s theory of lateral deflections by Deasy, J. O.

“…An algorithm is developed for computing proton dose distributions in the therapeutic energy range (100–250 MeV). The goal is to provide accurate pencil beam…”
Get full text

Image-based Data Mining to Probe Dosimetric Correlates of Radiation-induced Trismus by Beasley, William, Thor, Maria, McWilliam, Alan, Green, Andrew, Mackay, Ranald, Slevin, Nick, Olsson, Caroline, Pettersson, Niclas, Finizia, Caterina, Estilo, Cherry, Riaz, Nadeem, Lee, Nancy Y., Deasy, Joseph O., van Herk, Marcel

“…To identify imaged regions in which dose is associated with radiation-induced trismus after head and neck cancer radiation therapy (HNRT) using a novel…”
Get full text

Temporal patterns of patient‐reported trismus and associated mouth‐opening distances in radiotherapy for head and neck cancer: A prospective cohort study by Thor, M., Olsson, C. E., Oh, J. H., Hedström, J., Pauli, N., Johansson, M., Deasy, J. O., Finizia, C.

“…Objectives To identify temporal patterns of patient‐reported trismus during the first year post‐radiotherapy, and to study their associations with maximal…”
Get full text

TH‐C‐220‐07: Multi‐Compartmental Tumor Control Probability (TCP) Modeling Based on the Microenvironmental Conditions of a Tumor Sub‐Volume by Jeong, J, Deasy, J O

“…Purpose: The microenvironment varies throughout a tumor and is known to affect radiotherapy treatment response. In this study, impact of various…”
Get full text

MicroRT—Small animal conformal irradiator by Stojadinovic, S., Low, D. A., Hope, A. J., Vicic, M., Deasy, J. O., Cui, J., Khullar, D., Parikh, P. J., Malinowski, K. T., Izaguirre, E. W., Mutic, S., Grigsby, P. W.

“…A novel small animal conformal radiation therapy system has been designed and prototyped: MicroRT. The microRT system integrates multimodality imaging,…”
Get full text

Denoising of electron beam Monte Carlo dose distributions using digital filtering techniques by Deasy, J O

“…The Monte Carlo (MC) method has long been viewed as the ultimate dose distribution computational technique. The inherent stochastic dose fluctuations (i.e…”
Get more information

Dose response explorer: an integrated open-source tool for exploring and modelling radiotherapy dose-volume outcome relationships by El Naqa, I, Suneja, G, Lindsay, P E, Hope, A J, Alaly, J R, Vicic, M, Bradley, J D, Apte, A, Deasy, J O

“…Radiotherapy treatment outcome models are a complicated function of treatment, clinical and biological factors. Our objective is to provide clinicians and…”
Get more information

Influence of image slice thickness on rectal dose-response relationships following radiotherapy of prostate cancer by Olsson, C, Thor, M, Liu, M, Moissenko, V, Petersen, S E, Høyer, M, Apte, A, Deasy, J O

“…When pooling retrospective data from different cohorts, slice thicknesses of acquired computed tomography (CT) images used for treatment planning may vary…”
Get more information

Inter-institutional analysis demonstrates the importance of lower than previously anticipated dose regions to prevent late rectal bleeding following prostate radiotherapy by Thor, Maria, Jackson, Andrew, Zelefsky, Michael J., Steineck, Gunnar, Karlsdòttir, Asa, Høyer, Morten, Liu, Mitchell, Nasser, Nicola J., Petersen, Stine E., Moiseenko, Vitali, Deasy, Joseph O.

“…To investigate whether inter-institutional cohort analysis uncovers more reliable dose–response relationships exemplified for late rectal bleeding (LRB)…”
Get full text

A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results by Chao, K S, Deasy, J O, Markman, J, Haynie, J, Perez, C A, Purdy, J A, Low, D A

“…In a prospective clinical study, we tested the hypothesis that sparing the parotid glands may result in significant objective and subjective improvement of…”
Get more information

MO‐D‐WAB‐01: How OMICs Is Going to Impact Research Topics for Medical Physicists by Deasy, JO, Gevaert, O, Aerts, H

“…The ongoing revolution in genomics provides many new research opportunities for physicists. Two crucial research areas to advance clinical oncology include the…”
Get full text

SU‐D‐137‐07: Verification of the Method Used in Clinical Estimation of Alpha/beta Ratio, Using a Model Simulation Including Proliferation and Hypoxic Effects by Jeong, J, Deasy, JO

“…Purpose: We hypothesize that the interplay between cell kill, proliferation, and hypoxia make the traditional interpretation of clinically‐derived α/β ratios…”
Get full text