Search Results - "Dearolf, Charles R."

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 ( PTPN11) mutations by Mohi, M. Golam, Williams, Ifor R., Dearolf, Charles R., Chan, Gordon, Kutok, Jeffery L., Cohen, Sarah, Morgan, Kelly, Boulton, Christina, Shigematsu, Hirokazu, Keilhack, Heike, Akashi, Koichi, Gilliland, D. Gary, Neel, Benjamin G.

“…The SH2-containing tyrosine phosphatase Shp2 ( PTPN11) is required for growth factor and cytokine signaling. Germline Shp2 mutations cause Noonan Syndrome…”
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Analysis of Ras-induced overproliferation in Drosophila hemocytes by Asha, H, Nagy, Istvan, Kovacs, Gabor, Stetson, Daniel, Ando, Istvan, Dearolf, Charles R

“…We use the Drosophila melanogaster larval hematopoietic system as an in vivo model for the genetic and functional genomic analysis of oncogenic cell…”
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The National Institutes of Health Lasker Clinical Research Scholars Program: A Decade of Launching Clinician-Scientist Careers by Dearolf, Charles R, Lee, Janice S, Pickett, Christopher L, Santangelo, George, Schor, Nina F

“…In response to the decades-long decrease in U.S. clinician-scientists, the National Institutes of Health (NIH) and the Albert and Mary Lasker Foundation…”
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The Drosophila STAT Protein, Stat92E, Regulates Follicle Cell Differentiation during Oogenesis by Baksa, Katalin, Parke, Timothy, Dobens, Leonard L., Dearolf, Charles R.

“…Signal transducer and activator of transcription (STAT) proteins are transcription factors that play a critical role in the response of a variety of eukaryotic…”
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viking: identification and characterization of a second type IV collagen in Drosophila by Yasothornsrikul, Sukkid, Davis, Wendy J, Cramer, Gabrielle, Kimbrell, Deborah A, Dearolf, Charles R

“…We have taken an enhancer trap approach to identify genes that are expressed in hematopoietic cells and tissues of Drosophila. We conducted a molecular…”
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The Drosophila Jak Kinase Hopscotch Is Required for Multiple Developmental Processes in the Eye by Luo, Hong, Asha, H, Kockel, Lutz, Parke, Tim, Mlodzik, Marek, Dearolf, Charles R

“…Jak kinases are critical signaling components in hematopoiesis. While a large number of studies have been conducted on the roles of Jak kinases in the…”
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Identification of a Stat Gene That Functions in Drosophila Development by Yan, Riqiang, Small, Stephen, Desplan, Claude, Dearolf, Charles R, Darnell, James E

“…A Drosophila Stat gene ( D-Stat) with a zygotic segmental expression pattern was identified. This protein becomes phosphorylated on Tyr-704 when coexpressed in…”
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Targeted Recovery of Mutations in Drosophila by Bentley, Alyssa, MacLennan, Bridget, Calvo, Jonathan, Dearolf, Charles R

“…Reverse genetic techniques will be necessary to take full advantage of the genomic sequence data for Drosophila and other experimental organisms. To develop a…”
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caudal gene product is a direct activator of fushi tarazu transcription during Drosophila embryogenesis by Dearolf, C.R, Topol, J, Parker, C.S

“…A Drosophila pair-rule segmentation gene, fushi tarazu (ftz), encodes a protein which is expressed in a characteristic seven-stripe pattern. The promoter…”
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The JAK/STAT pathway and Drosophila development by Luo, Hong, Dearolf, Charles R.

“…The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of…”
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Fruit fly “leukemia” by Dearolf, Charles R

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A JAK-STAT pathway regulates wing vein formation in Drosophila by Yan, R. (The Rockefeller University, New York, NY.), Luo, H, Darnell, J.E. Jr, Dearolf, C.R

“…We present evidence that the JAK-STAT signal transduction pathway regulates multiple developmental processes in Drosophila. We screened for second-site…”
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Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways by Luo, Hong, Rose, Paul, Barber, Dwayne, Hanratty, William P., Lee, Sue, Roberts, Thomas M., D'Andrea, Alan D., Dearolf, Charles R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hyperactivation of the Drosophila Hop Jak kinase causes the preferential overexpression of eIF1A transcripts in larval blood cells by Myrick, Kyl V., Dearolf, Charles R.

“…Jak kinase–Stat protein pathways play a critical role in the response of blood cells to a range of cytokines and growth factors. We are using the fruit fly,…”
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Molecular consequences of awdb3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis by DEAROLF, C. R, TRIPOULAS, N, BIGGS, J, SHEARN, A

“…The abnormal wing disc locus, which is at salivary gland chromosome position 100C-D of the Drosophila melanogaster genome, has been identified by a recessive…”
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The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus by Hanratty, W P, Dearolf, C R

“…The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature…”
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Drosophila awdK–pn, a homologue of the metastasis suppressor gene nm23, suppresses the Tum–I haematopoietic oncogene by Zinyk, Dawn L., McGonnigal, Bethany G., Dearolf, Charles R.

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Drosophila awd K-pn , a homologue of the metastasis suppressor gene nm23, suppresses the Tum-I haematopoietic oncogene by Zinyk, Dawn L, McGonnigal, Bethany G, Dearolf, Charles R

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Synthetic oligonucleotides recreate Drosophila fushi tarazu zebra-stripe expression by TOPOL, J, DEAROLF, C. R, KULKARNI PRAKASH, PARKER, C. S

“…A complex array of activator and repressor elements located within 669 bp proximal to the fushi tarazu (ftz) transcriptional start site is sufficient to…”
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Developmental consequences of awd b3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis by Dearolf, Charles R., Hersperger, Evelyn, Shearn, Allen

“…In order to recover mutations affecting imaginal discs in a way which would allow the relevant genes to be readily cloned, a hybrid dysgenic screen was…”
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