Search Results - "Dearman, Rebecca"

An assessment of the ability of phthalates to influence immune and allergic responses by Kimber, Ian, Dearman, Rebecca J

“…Abstract It has been suggested that one possible contributor to the increasing prevalence of atopic (IgE-mediated) allergic diseases and asthma in Europe and…”
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Immunogenicity of therapeutic proteins: influence of aggregation by Ratanji, Kirsty D, Derrick, Jeremy P, Dearman, Rebecca J, Kimber, Ian

“…The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The…”
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Human neutrophil antigens: Nature, clinical significance and detection by Browne, Tom, Dearman, Rebecca J., Poles, Anthony

“…Granulocytes are an essential part of both the innate and adaptive immune systems. Human neutrophil antigens (HNAs) are a family of epitopes that are located…”
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Mechanistic Applicability Domain Classification of a Local Lymph Node Assay Dataset for Skin Sensitization by Roberts, David W, Patlewicz, Grace, Kern, Petra S, Gerberick, Frank, Kimber, Ian, Dearman, Rebecca J, Ryan, Cindy A, Basketter, David A, Aptula, Aynur O

“…The goal of eliminating animal testing in the predictive identification of chemicals with the intrinsic ability to cause skin sensitization is an important…”
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The aryl hydrocarbon receptor: differential contribution to T helper 17 and T cytotoxic 17 cell development by Hayes, Mark D, Ovcinnikovs, Vitalijs, Smith, Andrew G, Kimber, Ian, Dearman, Rebecca J

“…The aryl hydrocarbon receptor (AhR) has been shown to be required for optimal Thelper (Th) 17 cell activation. Th17 cells provide immunity against…”
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Chemical respiratory allergy: Reverse engineering an adverse outcome pathway by Kimber, Ian, Dearman, Rebecca J, Basketter, David A, Boverhof, Darrell R

“…Abstract Allergic sensitisation of the respiratory tract by chemicals is associated with rhinitis and asthma and remains an important occupational health…”
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The effect of arginine glutamate on the stability of monoclonal antibodies in solution by Kheddo, Priscilla, Tracka, Malgorzata, Armer, Jonathan, Dearman, Rebecca J., Uddin, Shahid, van der Walle, Christopher F., Golovanov, Alexander P.

“…[Display omitted] Finding excipients which mitigate protein self-association and aggregation is an important task during formulation. Here, the effect of an…”
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Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies by Rane, Shraddha S., Dearman, Rebecca J., Kimber, Ian, Uddin, Shahid, Bishop, Stephen, Shah, Maryam, Podmore, Adrian, Pluen, Alain, Derrick, Jeremy P.

“…Purpose Anti-drug antibodies can impair the efficacy of therapeutic proteins and, in some circumstances, induce adverse health effects. Immunogenicity can be…”
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Proteomic and Bioinformatic Analyses for the Identification of Proteins With Low Allergenic Potential for Hazard Assessment by Krutz, Nora L, Winget, Jason, Ryan, Cindy A, Wimalasena, Rohan, Maurer-Stroh, Sebastian, Dearman, Rebecca J, Kimber, Ian, Gerberick, G Frank

“…Abstract Use of botanicals and natural substances in consumer products has increased in recent years. Such extracts can contain protein that may theoretically…”
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The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies by Gurjar, Shalom A., Wheeler, Jun X., Wadhwa, Meenu, Thorpe, Robin, Kimber, Ian, Derrick, Jeremy P., Dearman, Rebecca J., Metcalfe, Clive

“…Therapeutic mAbs are used to manage a wide range of cancers and autoimmune disorders. However, mAb-based treatments are not always successful, highlighting the…”
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Identification of B cell epitopes enhanced by protein unfolding and aggregation by Eyes, Timothy J., Austerberry, James I., Dearman, Rebecca J., Johannissen, Linus O., Kimber, Ian, Smith, Noel, Thistlethwaite, Angela, Derrick, Jeremy P.

“…•Aggregation of an exemplar therapeutic antibody fragment (scFv) enhances immunogenicity in vivo.•Epitope mapping reveals immunogenicity is directed to a…”
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Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome by Ainscough, Joseph S., Frank Gerberick, G., Zahedi-Nejad, Maryam, Lopez-Castejon, Gloria, Brough, David, Kimber, Ian, Dearman, Rebecca J.

“…IL-1α and β are key players in the innate immune system. The secretion of these cytokines by dendritic cells (DC) is integral to the development of…”
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Interleukin-1β Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin by Ainscough, Joseph S., Gerberick, G. Frank, Kimber, Ian, Dearman, Rebecca J.

“…The secretion of IL-1β is a central event in the initiation of inflammation. Unlike most other cytokines, the secretion of IL-1β requires two signals: one…”
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Adaptation of an ELISA assay for detection of IgG2a responses against therapeutic monoclonal antibodies in a mouse immunization model by Rane, Shraddha S, Dearman, Rebecca J, Kimber, Ian, Derrick, Jeremy P

“…Biotherapeutic monoclonal antibodies (mAb) play important roles in clinical medicine but their potential to elicit immune responses in patients remains a major…”
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Chemical allergy: translating biology into hazard characterization by Kimber, Ian, Basketter, David A, Gerberick, G Frank, Ryan, Cindy A, Dearman, Rebecca J

“…The induction by chemicals of allergic sensitization and allergic disease is an important and challenging branch of toxicology. Skin sensitization resulting in…”
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Investigating Liquid–Liquid Phase Separation of a Monoclonal Antibody Using Solution-State NMR Spectroscopy: Effect of Arg·Glu and Arg·HCl by Kheddo, Priscilla, Bramham, Jack E, Dearman, Rebecca J, Uddin, Shahid, van der Walle, Christopher F, Golovanov, Alexander P

“…Liquid–liquid phase separation (LLPS) of monoclonal antibody (mAb) formulations involves spontaneous separation into dense (protein-rich) and diluted…”
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Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature by Crow, Yanick J, Briggs, Tracy A, Rice, Gillian I, Daly, Sarah, Urquhart, Jill, Gornall, Hannah, Bader-Meunier, Brigitte, Baskar, Kannan, Baskar, Shankar, Baudouin, Veronique, Beresford, Michael W, Black, Graeme C M, Dearman, Rebecca J, de Zegher, Francis, Foster, Emily S, Francès, Camille, Hayman, Alison R, Hilton, Emma, Job-Deslandre, Chantal, Kulkarni, Muralidhar L, Le Merrer, Martine, Linglart, Agnes, Lovell, Simon C, Maurer, Kathrin, Musset, Lucile, Navarro, Vincent, Picard, Capucine, Puel, Anne, Rieux-Laucat, Frederic, Roifman, Chaim M, Scholl-Bürgi, Sabine, Smith, Nigel, Szynkiewicz, Marcin, Wiedeman, Alice, Wouters, Carine, Zeef, Leo A H, Casanova, Jean-Laurent, Elkon, Keith B, Janckila, Anthony, Lebon, Pierre

“…We studied ten individuals from eight families showing features consistent with the immuno-osseous dysplasia spondyloenchondrodysplasia. Of particular note was…”
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Lower levels of interleukin‐1β gene expression are associated with impaired Langerhans’ cell migration in aged human skin by Pilkington, Suzanne M., Ogden, Stephanie, Eaton, Laura H., Dearman, Rebecca J., Kimber, Ian, Griffiths, Christopher E. M.

“…Summary Langerhans’ cells (LC) play pivotal roles in skin immune responses, linking innate and adaptive immunity. In aged skin there are fewer LC and migration…”
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The direct peptide reactivity assay: selectivity of chemical respiratory allergens by Lalko, Jon F, Kimber, Ian, Gerberick, G Frank, Foertsch, Leslie M, Api, Anne Marie, Dearman, Rebecca J

“…It is well known that some chemicals are capable of causing allergic diseases of the skin and respiratory tract. Commonly, though not exclusively, chemical…”
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T lymphocyte dynamics in methylisothiazolinone-allergic patients by Popple, Amy, Williams, Jason, Maxwell, Gavin, Gellatly, Nichola, Dearman, Rebecca J., Kimber, Ian

“…Summary Background Methylisothiazolinone (MI), a preservative that is commonly used in personal care products, is now recognized as an important contact…”
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