Search Results - "Dearling, Jason"

Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics by Dammes, Niels, Goldsmith, Meir, Ramishetti, Srinivas, Dearling, Jason L. J., Veiga, Nuphar, Packard, Alan B., Peer, Dan

“…The successful in vivo implementation of gene expression modulation strategies relies on effective, non-immunogenic delivery vehicles. Lipid nanoparticles are…”
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Molecular imaging in nanomedicine – A developmental tool and a clinical necessity by Dearling, Jason L.J., Packard, Alan B.

“…The development of nanomedicines presents the potential to deliver more potent drugs targeted more specifically to the site(s) of disease than is currently…”
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Detection and therapy of neuroblastoma minimal residual disease using [64/67Cu]Cu-SARTATE in a preclinical model of hepatic metastases by Dearling, Jason L. J., van Dam, Ellen M., Harris, Matthew J., Packard, Alan B.

“…Background A major challenge to the long-term success of neuroblastoma therapy is widespread metastases that survive initial therapy as minimal residual…”
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Some thoughts on the mechanism of cellular trapping of Cu(II)-ATSM by Dearling, Jason L.J, Packard, Alan B

“…Abstract Cu(II)-ATSM continues to be investigated, both in the laboratory and in the clinic, as a tumor hypoxia imaging agent. However, meaningful…”
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Low‐Fouling Zwitterionic Polymeric Colloids as Resuscitation Fluids for Hemorrhagic Shock by Kumar, Rajesh, Mancebo, Julia Garcia, Patenaude, Ryan, Sack, Kristen, Prondzynski, Maksymilian, Packard, Alan B., Dearling, Jason L. J., Li, Ruihan, Balcarcel‐Monzon, Michelle, Dominguez, Saffron, Emani, Sirisha, Kheir, John N., Polizzotti, Brian, Peng, Yifeng

“…Colloids, known as volume expanders, have been used as resuscitation fluids for hypovolemic shock for decades, as they increase plasma oncotic pressure and…”
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Positron Emission Tomography Detects In Vivo Expression of Disialoganglioside GD2 in Mouse Models of Primary and Metastatic Osteosarcoma by Butch, Elizabeth R, Mead, Paul E, Amador Diaz, Victor, Tillman, Heather, Stewart, Elizabeth, Mishra, Jitendra K, Kim, Jieun, Bahrami, Armita, Dearling, Jason L J, Packard, Alan B, Stoddard, Shana V, Vāvere, Amy L, Han, Yuanyuan, Shulkin, Barry L, Snyder, Scott E

“…The cell membrane glycolipid GD2 is expressed by multiple solid tumors, including 88% of osteosarcomas and 98% of neuroblastomas. However, osteosarcomas are…”
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The Ionic Charge of Copper-64 Complexes Conjugated to an Engineered Antibody Affects Biodistribution by Dearling, Jason L. J, Paterson, Brett M, Akurathi, Vamsidhar, Betanzos-Lara, Soledad, Treves, S. Ted, Voss, Stephan D, White, Jonathan M, Huston, James S, Smith, Suzanne V, Donnelly, Paul S, Packard, Alan B

“…The development of biomolecules as imaging probes requires radiolabeling methods that do not significantly influence their biodistribution. Sarcophagine (Sar)…”
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Colitis ImmunoPET: Defining Target Cell Populations and Optimizing Pharmacokinetics by Dearling, Jason L J, Daka, Ala, Veiga, Nuphar, Peer, Dan, Packard, Alan B

“…Positron emission tomography combined with a specific probe presents the ability to noninvasively assess inflammatory bowel disease. We previously reported…”
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Use of [18F]FDG Positron Emission Tomography to Monitor the Development of Cardiac Allograft Rejection by Daly, Kevin P, Dearling, Jason L J, Seto, Tatsuichiro, Dunning, Patricia, Fahey, Frederic, Packard, Alan B, Briscoe, David M

“…Positron emission tomography (PET) has the potential to be a specific, sensitive and quantitative diagnostic test for transplant rejection. To test this…”
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Mitochondrial transplantation: Effects on chemotherapy in prostate and ovarian cancer cells in vitro and in vivo by Celik, Aybuke, Orfany, Arzoo, Dearling, Jason, del Nido, Pedro J., McCully, James D., Bakar-Ates, Filiz

“…Prostate and ovarian cancers affect the male and female reproductive organs and are among the most common cancers in developing countries. Previous studies…”
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Predicting Response to Radioimmunotherapy from the Tumor Microenvironment of Colorectal Carcinomas by EL EMIR, Ethaar, QURESHI, Uzma, DEARLING, Jason L. J, BOXER, Geoffrey M, CLATWORTHY, Innes, FOLARIN, Amos A, ROBSON, Mathew P, NAGL, Sylvia, KONERDING, Moritz A, PEDLEY, R. Barbara

“…Solid tumors have a heterogeneous pathophysiology, which directly affects antibody-targeted therapies. Here, we consider the influence of selected tumor…”
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In vivo detection of antigen-specific CD8+ T cells by immuno-positron emission tomography by Woodham, Andrew W., Zeigler, Stad H., Zeyang, Ella L., Kolifrath, Stephen C., Cheloha, Ross W., Rashidian, Mohammad, Chaparro, Rodolfo J., Seidel, Ronald D., Garforth, Scott J., Dearling, Jason L., Mesyngier, Maia, Duddempudi, Phaneendra K., Packard, Alan B., Almo, Steven C., Ploegh, Hidde L.

“…The immune system’s ability to recognize peptides on major histocompatibility molecules contributes to the eradication of cancers and pathogens. Tracking these…”
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On the destiny of (copper) species by Dearling, Jason L J, Packard, Alan B

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Imaging cancer using PET — the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody by Dearling, Jason L.J., Voss, Stephan D., Dunning, Patricia, Snay, Erin, Fahey, Frederic, Smith, Suzanne V., Huston, James S., Meares, Claude F., Treves, S. Ted, Packard, Alan B.

“…Use of copper radioisotopes in antibody radiolabeling is challenged by reported loss of the radionuclide from the bifunctional chelator used to label the…”
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A Sensitive Method for the Measurement of Copper at Trace Levels Using an HPLC-Based Assay by Dearling, Jason L J, Packard, Alan B

“…Measurement of trace metal contamination is critical in the production of radiometals, such as 64Cu, for protein labeling. ICP-MS provides these data with high…”
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Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships by Dearling, Jason L J, Lewis, Jason S, Mullen, Gregory E D, Welch, Michael J, Blower, Philip J

“…Copper(II) bis(thiosemicarbazone) complexes labelled with Cu-60/62/64 are useful radiopharmaceuticals for imaging blood flow and hypoxic tissues in vivo. The…”
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Combining Radioimmunotherapy with Antihypoxia Therapy 2-Deoxy-d-Glucose Results in Reduction of Therapeutic Efficacy by DEARLING, Jason L. J, QURESHI, Uzma, BEGENT, Richard H. J, PEDLEY, R. Barbara

“…Purpose: The efficacy of solid tumor radioimmunotherapy is reduced by heterogeneous tumor distribution of the radionuclide, with dose mainly deposited in the…”
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Targeted Imaging of Ewing Sarcoma in Preclinical Models Using a 64Cu-Labeled Anti-CD99 Antibody by O'NEILL, Allison F, DEARLING, Jason L. J, YUCHUAN WANG, TUPPER, Tanya, YANPING SUN, ASTER, Jon C, CALICCHIO, Monica L, PEREZ-ATAYDE, Antonio R, PACKARD, Alan B, KUNG, Andrew L

“…Ewing sarcoma is a tumor of the bone and soft tissue characterized by diffuse cell membrane expression of CD99 (MIC2). Single-site, surgically resectable…”
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Localization of radiolabeled anti-CEA antibody in subcutaneous and intrahepatic colorectal xenografts: influence of tumor size and location within host organ on antibody uptake by Dearling, Jason L.J, Flynn, Aiden A, Qureshi, Uzma, Whiting, Stephen, Boxer, Geoffrey M, Green, Alan, Begent, Richard H.J, Pedley, R. Barbara

“…Abstract Introduction Radioimmunotherapy (RIT) has been shown to be more effective against solid tumor micrometastases, possibly due to an inverse relationship…”
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Microdistribution of Targeted, Fluorescently Labeled Anti–Carcinoembryonic Antigen Antibody in Metastatic Colorectal Cancer: Implications for Radioimmunotherapy by Fidarova, Elena F., El-Emir, Ethaar, Boxer, Geoffrey M., Qureshi, Uzma, Dearling, Jason L.J., Robson, Mathew P., Begent, Richard H.J., Trott, Klaus R., Pedley, R. Barbara

“…Purpose: Most radioimmunotherapy studies on radiolabeled antibody distribution are based on autoradiographic and radioluminographic data, which provide a lack…”
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