Search Results - "Dear, Paul"

Digital PCR strategies in the development and analysis of molecular biomarkers for personalized medicine by Day, Elizabeth, Dear, Paul H., McCaughan, Frank

“…The efficient delivery of personalized medicine is a key goal of healthcare over the next decade. It is likely that PCR strategies will play an important role…”
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Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary by Krause, Johannes, Unger, Tina, Noçon, Aline, Malaspinas, Anna-Sapfo, Kolokotronis, Sergios-Orestis, Stiller, Mathias, Soibelzon, Leopoldo, Spriggs, Helen, Dear, Paul H, Briggs, Adrian W, Bray, Sarah C E, O'Brien, Stephen J, Rabeder, Gernot, Matheus, Paul, Cooper, Alan, Slatkin, Montgomery, Pääbo, Svante, Hofreiter, Michael

“…Despite being one of the most studied families within the Carnivora, the phylogenetic relationships among the members of the bear family (Ursidae) have long…”
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Genomic analysis of the causative agents of coccidiosis in domestic chickens by Reid, Adam J, Blake, Damer P, Ansari, Hifzur R, Billington, Karen, Browne, Hilary P, Bryant, Josephine, Dunn, Matt, Hung, Stacy S, Kawahara, Fumiya, Miranda-Saavedra, Diego, Malas, Tareq B, Mourier, Tobias, Naghra, Hardeep, Nair, Mridul, Otto, Thomas D, Rawlings, Neil D, Rivailler, Pierre, Sanchez-Flores, Alejandro, Sanders, Mandy, Subramaniam, Chandra, Tay, Yea-Ling, Woo, Yong, Wu, Xikun, Barrell, Bart, Dear, Paul H, Doerig, Christian, Gruber, Arthur, Ivens, Alasdair C, Parkinson, John, Rajandream, Marie-Adèle, Shirley, Martin W, Wan, Kiew-Lian, Berriman, Matthew, Tomley, Fiona M, Pain, Arnab

“…Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are…”
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Deeply conserved synteny and the evolution of metazoan chromosomes by Simakov, Oleg, Bredeson, Jessen, Berkoff, Kodiak, Marletaz, Ferdinand, Mitros, Therese, Schultz, Darrin T, O'Connell, Brendan L, Dear, Paul, Martinez, Daniel E, Steele, Robert E, Green, Richard E, David, Charles N, Rokhsar, Daniel S

“…Animal genomes show networks of deeply conserved gene linkages whose phylogenetic scope and chromosomal context remain unclear. Here, we report…”
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Aerotaxis Assay in Caenorhabditis elegans to Study Behavioral Plasticity by Li, Qiaochu, Marcu, Daniel-Cosmin, Dear, Paul H, Busch, Karl Emanuel

“…shows robust and reproducible behavioral responses to oxygen. Specifically, worms prefer O levels of 5-10% and avoid too high or too low O . Their O preference…”
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Perigone Lobe Transcriptome Analysis Provides Insights into Rafflesia cantleyi Flower Development by Lee, Xin-Wei, Mat-Isa, Mohd-Noor, Mohd-Elias, Nur-Atiqah, Aizat-Juhari, Mohd Afiq, Goh, Hoe-Han, Dear, Paul H, Chow, Keng-See, Haji Adam, Jumaat, Mohamed, Rahmah, Firdaus-Raih, Mohd, Wan, Kiew-Lian

“…Rafflesia is a biologically enigmatic species that is very rare in occurrence and possesses an extraordinary morphology. This parasitic plant produces a…”
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Single-molecule DNA sequencing of widely varying GC-content using nucleotide release, capture and detection in microdroplets by Puchtler, Tim J, Johnson, Kerr, Palmer, Rebecca N, Talbot, Emma L, Ibbotson, Lindsey A, Powalowska, Paulina K, Knox, Rachel, Shibahara, Aya, M. S. Cunha, Pedro, Newell, Oliver J, Wu, Mei, Chana, Jasmin, Athanasopoulou, Evangelia-Nefeli, Waeber, Andreas M, Stolarek, Magdalena, Silva, Ana-Luisa, Mordaka, Justyna M, Haggis-Powell, Michael, Xyrafaki, Christina, Bush, James, Topkaya, Ibrahim S, Sosna, Maciej, Ingham, Richard J, Huckvale, Thomas, Negrea, Aurel, Breiner, Boris, Šlikas, Justinas, Kelly, Douglas J, Dunning, Alexander J, Bell, Neil M, Dethlefsen, Mark, Love, David M, Dear, Paul H, Kuleshova, Jekaterina, Podd, Gareth J, Isaac, Tom H, Balmforth, Barnaby W, Frayling, Cameron A

“…Abstract Despite remarkable progress in DNA sequencing technologies there remains a trade-off between short-read platforms, having limited ability to sequence…”
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Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum by Abrahamsen, Mitchell S., Templeton, Thomas J., Enomoto, Shinichiro, Abrahante, Juan E., Zhu, Guan, Lancto, Cheryl A., Deng, Mingqi, Liu, Chang, Widmer, Giovanni, Tzipori, Saul, Buck, Gregory A., Xu, Ping, Bankier, Alan T., Dear, Paul H., Konfortov, Bernard A., Spriggs, Helen F., Iyer, Lakshminarayan, Anantharaman, Vivek, Aravind, L., Kapur, Vivek

“…The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in…”
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Towards accurate exclusion of neonatal bacterial meningitis: a feasibility study of a novel 16S rDNA PCR assay by Abelian, Arthur, Mund, Thomas, Curran, Martin D, Savill, Stuart A, Mitra, Nipa, Charan, Carol, Ogilvy-Stuart, Amanda L, Pelham, Hugh R. B, Dear, Paul H

“…Abstract Background PCRctic is an innovative assay based on 16S rDNA PCR technology that has been designed to detect a single intact bacterium in a specimen of…”
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Single-molecule genomics by McCaughan, Frank, Dear, Paul H

“…The term 'single-molecule genomics' (SMG) describes a group of molecular methods in which single molecules are detected or sequenced. The focus on the analysis…”
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Progressive 3q Amplification Consistently Targets SOX2 in Preinvasive Squamous Lung Cancer by MCCAUGHAN, Frank, POLE, Jessica C. M, BANKIER, Alan T, KONFORTOV, Bernard A, CARROLL, Bernadette, FALZON, Mary, RABBITTS, Terence H, GEORGE, P. Jeremy, DEAR, Paul H, RABBITTS, Pamela H

“…Amplification of distal 3q is the most common genomic aberration in squamous lung cancer (SQC). SQC develops in a multistage progression from normal bronchial…”
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Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae by Hofreiter, Michael, Krause, Johannes, Dear, Paul H, Pollack, Joshua L, Slatkin, Montgomery, Spriggs, Helen, Barnes, Ian, Lister, Adrian M, Ebersberger, Ingo, Pääbo, Svante

“…In studying the genomes of extinct species, two principal limitations are typically the small quantities of endogenous ancient DNA and its degraded condition,…”
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Copy-number variation: the end of the human genome? by Dear, Paul H

“…Copy-number variation (CNV) – the presence of additional or missing segments of chromosomes in some individuals – has been found to be abundant in humans and…”
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The genome of Cryptosporidium hominis by Buck, Gregory A, Xu, Ping, Widmer, Giovanni, Wang, Yingping, Ozaki, Luiz S, Alves, Joao M, Serrano, Myrna G, Puiu, Daniela, Manque, Patricio, Akiyoshi, Donna, Mackey, Aaron J, Pearson, William R, Dear, Paul H, Bankier, Alan T, Peterson, Darrell L, Abrahamsen, Mitchell S, Kapur, Vivek, Tzipori, Saul

“…Cryptosporidium species cause acute gastroenteritis and diarrhoea worldwide. They are members of the Apicomplexa-protozoan pathogens that invade host cells by…”
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Single-molecule detection of deoxyribonucleoside triphosphates in microdroplets by Breiner, Boris, Johnson, Kerr, Stolarek, Magdalena, Silva, Ana-Luisa, Negrea, Aurel, Bell, Neil M, Isaac, Tom H, Dethlefsen, Mark, Chana, Jasmin, Ibbotson, Lindsey A, Palmer, Rebecca N, Bush, James, Dunning, Alexander J, Love, David M, Pachoumi, Olympia, Kelly, Douglas J, Shibahara, Aya, Wu, Mei, Sosna, Maciej, Dear, Paul H, Tolle, Fabian, Petrini, Edoardo, Amasio, Michele, Shelford, Leigh R, Saavedra, Monica S, Sheridan, Eoin, Kuleshova, Jekaterina, Podd, Gareth J, Balmforth, Barnaby W, Frayling, Cameron A

“…A new approach to single-molecule DNA sequencing in which dNTPs, released by pyrophosphorolysis from the strand to be sequenced, are captured in microdroplets…”
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Insights into the genome structure and copy-number variation of Eimeria tenella by Lim, Lik-Sin, Tay, Yea-Ling, Alias, Halimah, Wan, Kiew-Lian, Dear, Paul H

“…Eimeria is a genus of parasites in the same phylum (Apicomplexa) as human parasites such as Toxoplasma, Cryptosporidium and the malaria parasite Plasmodium. As…”
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IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer by Day, Elizabeth, Poulogiannis, George, McCaughan, Frank, Mulholland, Shani, Arends, Mark J., Ibrahim, Ashraf E. K., Dear, Paul H.

“…Summary Copy number alterations are frequently found in colorectal cancer (CRC), and recurrent gains or losses are likely to correspond to regions harbouring…”
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Comparative Genome Analysis Reveals Divergent Genome Size Evolution in a Carnivorous Plant Genus by Vu, Giang T. H., Schmutzer, Thomas, Bull, Fabian, Cao, Hieu X., Fuchs, Jörg, Tran, Trung D., Jovtchev, Gabriele, Pistrick, Klaus, Stein, Nils, Pecinka, Ales, Neumann, Pavel, Novak, Petr, Macas, Jiri, Dear, Paul H., Blattner, Frank R., Scholz, Uwe, Schubert, Ingo

“…The C‐value paradox remains incompletely resolved after >40 yr and is exemplified by 2,350‐fold variation in genome sizes of flowering plants. The carnivorous…”
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Numts help to reconstruct the demographic history of the ocellated lizard (Lacerta lepida) in a secondary contact zone by MIRALDO, ANDREIA, HEWITT, GODFREY M., DEAR, PAUL H., PAULO, OCTAVIO S., EMERSON, BRENT C.

“…In northwestern Iberia, two largely allopatric Lacerta lepida mitochondrial lineages occur, L5 occurring to the south of Douro River and L3 to the north, with…”
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Multiplex amplification of ancient DNA by Hofreiter, Michael, Römpler, Holger, Dear, Paul H, Krause, Johannes, Meyer, Matthias, Rohland, Nadin, Schöneberg, Torsten, Spriggs, Helen, Stiller, Mathias

“…This method is designed to assemble long, continuous DNA sequences using minimal amounts of fragmented ancient DNA as template. This is achieved by a two-step…”
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