Search Results - "Dear, JW"

Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury by Vliegenthart, ADB, Kimmitt, RA, Seymour, JH, Homer, NZ, Clarke, JI, Eddleston, M, Gray, A, Wood, DM, Dargan, PI, Cooper, JG, Antoine, DJ, Webb, DJ, Lewis, SC, Bateman, DN, Dear, JW

“…Acetaminophen (paracetamol‐APAP) is the most common cause of drug‐induced liver injury in the Western world. Reactive metabolite production by cytochrome P450…”
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Long‐term adverse effects of paracetamol – a review by McCrae, J. C., Morrison, E. E., MacIntyre, I. M., Dear, J. W., Webb, D. J.

“…Paracetamol (acetaminophen) is the most commonly used drug in the world, with a long record of use in acute and chronic pain. In recent years, the benefits of…”
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Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature by Caparrotta, Thomas M., Antoine, Daniel J., Dear, James W.

“…Purpose Paracetamol is one of the world’s most commonly used drugs. In overdose, it is well established to be hepatotoxic. The aim of this review was to…”
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Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity by Antoine, Daniel J, Jenkins, Rosalind E, Dear, James W, Williams, Dominic P, McGill, Mitchell R, Sharpe, Matthew R, Craig, Darren G, Simpson, Kenneth J, Jaeschke, Hartmut, Park, B. Kevin

“…Background & Aims Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen…”
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Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment by Farrah, Tariq E., Pugh, Dan, Chapman, Fiona A., Godden, Emily, Balmforth, Craig, Oniscu, Gabriel C., Webb, David J., Dhillon, Baljean, Dear, James W., Bailey, Matthew A., Gallacher, Peter J., Dhaun, Neeraj

“…In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response,…”
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Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies by Dear, James W, Clarke, Joanna I, Francis, Ben, Allen, Lowri, Wraight, Jonathan, Shen, Jasmine, Dargan, Paul I, Wood, David, Cooper, Jamie, Thomas, Simon H L, Jorgensen, Andrea L, Pirmohamed, Munir, Park, B Kevin, Antoine, Daniel J

“…Paracetamol overdose is common but patient stratification is suboptimal. We investigated the usefulness of new biomarkers that have either enhanced liver…”
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Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery by Zhou, H., Yuen, P.S.T., Pisitkun, T., Gonzales, P.A., Yasuda, H., Dear, J.W., Gross, P., Knepper, M.A., Star, R.A.

“…Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein…”
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Are rare diseases still orphans or happily adopted? The challenges of developing and using orphan medicinal products by Dear, James W., Lilitkarntakul, Pajaree, Webb, David J.

“…Orphan medicinal products (OMPs) are targeted at the diagnosis, prevention or treatment of rare diseases and have a special status in European law. This status…”
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Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: Acute renal failure is dependent on MyD88 but not renal cell apoptosis by Dear, J.W., Yasuda, H., Hu, X., Hieny, S., Yuen, P.S.T., Hewitt, S.M., Sher, A., Star, R.A.

“…Toll-like receptors (TLRs) are important in sepsis. Myeloid differentiation factor 88 (MyD88) is a key molecule involved in signal transduction by multiple…”
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Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice by Dear, James W., Kobayashi, Hisataka, Jo, Sang-Kyung, Holly, Mikaela K., Hu, Xuzhen, Yuen, Peter S.T., Brechbiel, Martin W., Star, Robert A.

“…Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice. Acute renal failure (ARF) induced by sepsis…”
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Estimated glomerular filtration rate results are misleading in acute kidney disease by Dear, J W

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Delayed DMSO administration protects the kidney from mercuric chloride-induced injury by JO, Sang-Kyung, XUZHEN HU, YUEN, Peter S. T, ASLAMKHAN, Amy G, PRITCHARD, John B, DEAR, James W, STAR, Robert A

“…Reactive oxygen species are implicated as mediators of tissue damage in ischemic and toxic acute renal failure. Whereas many agents can inhibit renal ischemic…”
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Involvement of kinins in hyperresponsiveness induced by platelet activating factor in the human nasal airway by Turner, P J, Dear, J W, Foreman, J C

“…The aim of this study was to investigate the role of kinins in the development of nasal hyperresponsiveness induced by platelet activating factor (PAF) in…”
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Reduction by N G ‐nitro‐L‐arginine methyl ester (L‐NAME) of antigen‐induced nasal airway plasma extravasation in human subjects in vivo by Dear, J.W., Scadding, G.K., Foreman, J.C.

“…In non‐allergic subjects, histamine induced a reduction of minimal nasal cross‐sectional area (Amin) and an increase in albumin release into nasal lavage. The…”
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Attenuation of human nasal airway responses to bradykinin and histamine by inhibitors of nitric oxide synthase by Dear, J.W., Ghali, S., Foreman, J.C.

“…1 The effects of inhibitors of nitric oxide synthase and local anaesthetics were studied on changes in human nasal airway patency and albumin extravasation in…”
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Characterization of the bradykinin receptor in the human nasal airway using the binding of [125I]‐Hoe 140 by Dear, J.W., Wirth, K., Scadding, G.K., Foreman, J.C.

“…1 The aim of this study was to characterize the kinin receptor in the human nasal airway using [125I]‐Hoe 140 binding to a membrane preparation from human…”
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The contribution of histamine to the action of bradykinin in the human nasal airway by Austin, C.E., Dear, J.W., Neighbour, H., Lund, V., Foreman, J.C.

“…Bradykinin, 10 to 1000 μg given by aerosol into the nasal cavity of normal, healthy volunteers, produced a dose-related increase of nasal airway resistance…”
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