Search Results - "Dear, G. J."

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma by Dear, G.J., Roberts, A.D., Beaumont, C., North, S.E.

“…Definitive information on the metabolism of a drug candidate in humans is achieved through dosing radiolabelled drug as part of a clinical study, and is…”
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TopCount coupled to ultra-performance liquid chromatography for the profiling of radiolabeled drug metabolites in complex biological samples by Dear, G.J., Patel, N., Kelly, P.J., Webber, L., Yung, M.

“…The recent commercial availability of small particle packed columns (<2 μm) and associated instrumentation capable of withstanding the high pressures of such…”
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The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma by Ayrton, J., Dear, G. J., Leavens, W. J., Mallett, D. N., Plumb, R. S.

“…The use of turbulent flow chromatography coupled to mass spectrometry (turbulent flow LC/MS) shows great potential for the rapid, direct analysis of…”
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The determination of nicotinic acid in plasma by mixed-mode liquid chromatography–tandem mass spectrometry following ion exchange solid phase extraction by Mallett, D.N., Dayal, S., Dear, G.J., Pateman, A.J.

“…An assay for nicotinic acid in plasma samples has been developed using ion exchange solid phase extraction in 96-well format followed by mixed-mode ion…”
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Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct on-line analysis of pharmaceuticals in plasma by Ayrton, J, Dear, G.J, Leavens, W.J, Mallett, D.N, Plumb, R.S

“…The use of ultra-high flow-rate chromatography coupled to mass spectrometry offers great potential for the rapid, on-line analysis of pharmaceutical compounds…”
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Ultra-performance liquid chromatography coupled to linear ion trap mass spectrometry for the identification of drug metabolites in biological samples by Dear, G. J., James, A. D., Sarda, S.

“…The coupling of ultra‐performance liquid chromatography, operating at elevated pressures, to a linear ion trap mass spectrometer provides a high‐performance…”
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Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substrates by Ayrton, J., Plumb, R., Leavens, W. J., Mallett, D., Dickins, M., Dear, G. J.

“…A liquid chromatography tandem mass spectrometry (LC/MS/MS) method has been developed for the fast routine analysis of selected CYP450 probe substrate…”
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Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review by Plumb, R. S., Dear, G. J., Mallett, D. N., Higton, D. M., Pleasance, S., Biddlecombe, R. A.

“…1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and…”
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Characterization of the metabolites of alosetron in experimental animals and human by Ismail, I. M, Andrew, P. D, Cholerton, J, Roberts, A. D, Dear, G. J, Taylor, S, Koch, K. M, Saynor, D. A

“…The metabolism of radiolabelled alosetron was studied in rat, dog, rabbit, mouse and human. The metabolism in rat and dog was studied at a low and an elevated…”
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The rapid identification of drug metabolites using capillary liquid chromatography coupled to an ion trap mass spectrometer by Dear, G. J., Ayrton, J., Plumb, R., Fraser, I. J.

“…Capillary liquid chromatography (LC) using a 320 µm column and a flow rate of 10 µL/min has been coupled to an ion trap mass spectrometer using electrospray…”
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Urinary metabolites of a novel quinoxaline non-nucleoside reverse transcriptase inhibitor in rabbit, mouse and human: identification of fluorine NIH shift metabolites using NMR and tandem MS by Dear, G. J., Ismail, I. M., Mutch, P. J., Plumb, R. S., Davies, L. H., Sweatman, B. C.

“…1. The urinary metabolites of (S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydro-2H-quinoxaline-carboxylic acid isopropylester (GW420867X) have been investigated in…”
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Utilizing a -100 degrees C microplate CCD Imager, yttrium silicate coated 384-microplates and ultra-performance liquid chromatography for improved profiling of radiolabeled drug metabolites in complex biological samples by Dear, G J, Patel, N, Weightman, Alan, Pirard, Hans, Talvitie, Miika

“…The recent commercial availability of small particle packed columns (<2 microm) and associated instrumentation capable of withstanding the high pressures of…”
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Ultra-high flow rate capillary liquid chromatography with mass spectrometric detection for the direct analysis of pharmaceuticals in plasma at sub-nanogram per millilitre concentrations by Ayrton, J., Clare, R. A., Dear, G. J., Mallett, D. N., Plumb, R. S.

“…Ultra‐high flow rate liquid chromatography on large particle size stationary phases coupled with mass spectrometric detection (particularly tandem mass…”
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Formation of a defluorinated metabolite of a quinoxaline antiviral drug catalysed by human cytochrome P450 1A2 by Mutch, Peter J., Dear, Gordon J., Ismail, Issy M.

“…The in‐vitro metabolism of GW420867X ((S)‐2‐ethyl‐7‐fluoro‐3‐oxo‐3, 4‐dihydro‐2H‐quinoxaline‐1‐carboxylic acid isopropyl ester), a quinoxaline drug for the…”
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Utilizing a −100 °C microplate CCD Imager, yttrium silicate coated 384-microplates and ultra-performance liquid chromatography for improved profiling of radiolabeled drug metabolites in complex biological samples by Dear, G.J., Patel, N., Weightman, Alan, Pirard, Hans, Talvitie, Miika

“…The recent commercial availability of small particle packed columns (<2 μm) and associated instrumentation capable of withstanding the high pressures of such…”
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N-O glucuronidation: a major human metabolic pathway in the elimination of two novel anticonvulsant drug candidates by Ismail, I. M., Dear, G. J., Roberts, A. D., Plumb, R. S., Ayrton, J., Sweatman, B. C., Bowers, G. D.

“…1. The urinary metabolites of the anti-convulsant compound 4-amino-1-(2,6-difluorobenzyl)-1H-1,2,3-triazolo[4,5-c]-pyridine hydrochloride (GI265080) obtained…”
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Determination of 4-hydroxytamoxifen in mouse plasma in the pg/mL range by gradient capillary liquid chromatography/tandem mass spectrometry by Plumb, R. S., Warwick, H., Higton, D., Dear, G. J., Mallett, D. N.

“…Capillary high‐performance liquid chromatography (HPLC; 300 µm i.d.) coupled to tandem mass spectrometry has been used to determine the concentration of…”
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The use of preparative high performance liquid chromatography with tandem mass spectrometric directed fraction collection for the isolation and characterisation of drug metabolites in urine by nuclear magnetic resonance spectroscopy and liquid chromatography/sequential mass spectrometry by Plumb, R. S., Ayrton, J., Dear, G. J., Sweatman, B. C., Ismail, I. M.

“…Preparative high performance liquid chromatography (HPLC) coupled to tandem mass spectrometry has been used successfully for the isolation of several drug…”
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The potential of serially coupled alkyl-bonded silica monolithic columns for high resolution separations of pharmaceutical compounds in biological fluids by DEAR, G. J, MALLETT, D. N, HIGTOR, D. M, ROBERTS, A. D, BIRD, S. A, YOUNG, H, PLUMB, R. S, ISMAIL, I. M

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Direct analysis of a polar pharmaceutical compound in plasma using ultra-high flow rate liquid chromatography/mass spectrometry with a mixed-mode column by Mallett, D.N., Dear, G.J., Plumb, R.S.

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