Search Results - "Deans, Jonathan"
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Impact of various high fat diets on gene expression and the microbiome across the mouse intestines
Published in Scientific reports (27-12-2023)“…High fat diets (HFDs) have been linked to several diseases including obesity, diabetes, fatty liver, inflammatory bowel disease (IBD) and colon cancer. In this…”
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Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
Published in Nature communications (19-10-2018)“…Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of liver-specific gene expression with potent tumor suppressor activity, yet many liver tumors…”
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Duthie v HMA: Clarification on Corroboration
Published in The Edinburgh law review (01-09-2021)“…In the latest edition of Walker and Walker's "The Law of Evidence in Scotland" it is noted that the "appeal court has recently left open the question of…”
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Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells
Published in Molecular and cellular biology (01-10-2015)“…The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) is tumor suppressive in the liver but amplified in colon cancer, suggesting that it also might be…”
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Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice
Published in Endocrinology (Philadelphia) (01-02-2020)“…Abstract Soybean oil consumption has increased greatly in the past half-century and is linked to obesity and diabetes. To test the hypothesis that soybean oil…”
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HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver
Published in Frontiers in endocrinology (Lausanne) (04-12-2023)“…Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2) which drive the expression of…”
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Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis
Published in RNA (Cambridge) (01-11-2007)“…As the genomes of more eukaryotic pathogens are sequenced, understanding how molecular differences between parasite and host might be exploited to provide new…”
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Nasal polyposis: unusual indication for tracheostomy
Published in Journal of laryngology and otology (01-04-2004)“…A rare case of nasal polyposis requiring urgent tracheostomy is reported. A 70-year-old male presented to the hospital with stridor. He had a 10-year history…”
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P10-012-23 Impact of Various High Fat Diets on Intestinal Gene Expression in Mouse
Published in Current developments in nutrition (01-07-2023)Get full text
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SUN-LB119 Role of HNF4a Isoforms in the Carbohydrate/Lipid Switch in the Liver and Responsiveness to AMPK
Published in Journal of the Endocrine Society (08-05-2020)“…Hepatocyte Nuclear Factor 4α (HNF4α), the master regulator of liver-specific gene expression, is regulated by two promoters (P1 and P2) which drive expression…”
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The role of nuclear receptors in tissue-specific gene expression: The impact of genetic variation on DNA binding
Published 01-01-2017“…Nuclear receptors (NRs) are ligand-sensitive transcription factors that regulate a wide array of biological processes including development, metabolism, and…”
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Dissertation -
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SUN-101 Dysregulation of Hypothalamic Gene Expression by Soybean Oil Diets in Mice
Published in Journal of the Endocrine Society (30-04-2019)“…Soybean oil is a major component of the American diet and its increased consumption correlates positively with the prevalence of obesity and diabetes in the…”
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SUN-023 HNF4a Isoforms Regulate the Circadian Balance between Carbohydrate and Fatty Acid Metabolism in the Liver
Published in Journal of the Endocrine Society (30-04-2019)“…Nuclear receptor genes often contain alternative promoters but the physiological relevance of the different promoters or the proteins they generate is largely…”
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Relation-weighted Link Prediction for Disease Gene Identification
Published 10-11-2020“…Identification of disease genes, which are a set of genes associated with a disease, plays an important role in understanding and curing diseases. In this…”
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