Search Results - "Dean, S. N."

Machine learning for design of degenerate Cas13a crRNAs using lassa virus as a model of highly variable RNA target by Leski, T. A., Spangler, J. R., Wang, Z., Schultzhaus, Z., Taitt, C. R., Dean, S. N., Stenger, D. A.

“…The design of minimum CRISPR RNA (crRNA) sets for detection of diverse RNA targets using sequence degeneracy has not been systematically addressed. We tested…”
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Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis by Sirvent, Sofia, Vallejo, Andres F., Corden, Emma, Teo, Ying, Davies, James, Clayton, Kalum, Seaby, Eleanor G., Lai, Chester, Ennis, Sarah, Alyami, Rfeef, Douilhet, Gemma, Dean, Lareb S. N., Loxham, Matthew, Horswill, Sarah, Healy, Eugene, Roberts, Graham, Hall, Nigel J., Friedmann, Peter S., Singh, Harinder, Bennett, Clare L., Ardern-Jones, Michael R, Polak, Marta E.

“…Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus…”
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A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection by Blume, Cornelia, Jackson, Claire L., Spalluto, Cosma Mirella, Legebeke, Jelmer, Nazlamova, Liliya, Conforti, Franco, Perotin, Jeanne-Marie, Frank, Martin, Butler, John, Crispin, Max, Coles, Janice, Thompson, James, Ridley, Robert A., Dean, Lareb S. N., Loxham, Matthew, Reikine, Stephanie, Azim, Adnan, Tariq, Kamran, Johnston, David A., Skipp, Paul J., Djukanovic, Ratko, Baralle, Diana, McCormick, Christopher J., Davies, Donna E., Lucas, Jane S., Wheway, Gabrielle, Mennella, Vito

“…Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers…”
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Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation by Meldrum, Kirsty, Robertson, Sarah B, Römer, Isabella, Marczylo, Tim, Dean, Lareb S N, Rogers, Andrew, Gant, Timothy W, Smith, Rachel, Tetley, Terry D, Leonard, Martin O

“…Nanomaterial inhalation represents a potential hazard for respiratory conditions such as asthma. Cerium dioxide nanoparticles (CeO NPs) have the ability to…”
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Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis by Brereton, Christopher J, Yao, Liudi, Davies, Elizabeth R, Zhou, Yilu, Vukmirovic, Milica, Bell, Joseph A, Wang, Siyuan, Ridley, Robert A, Dean, Lareb S N, Andriotis, Orestis G, Conforti, Franco, Brewitz, Lennart, Mohammed, Soran, Wallis, Timothy, Tavassoli, Ali, Ewing, Rob M, Alzetani, Aiman, Marshall, Benjamin G, Fletcher, Sophie V, Thurner, Philipp J, Fabre, Aurelie, Kaminski, Naftali, Richeldi, Luca, Bhaskar, Atul, Schofield, Christopher J, Loxham, Matthew, Davies, Donna E, Wang, Yihua, Jones, Mark G

“…Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that…”
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Towards an artificial human lung: modelling organ-like complexity to aid mechanistic understanding by Humbert, Maria Victoria, Spalluto, Cosma Mirella, Bell, Joseph, Blume, Cornelia, Conforti, Franco, Davies, Elizabeth R, Dean, Lareb S N, Elkington, Paul, Haitchi, Hans Michael, Jackson, Claire, Jones, Mark G, Loxham, Matthew, Lucas, Jane S, Morgan, Hywel, Polak, Marta, Staples, Karl J, Swindle, Emily J, Tezera, Liku, Watson, Alastair, Wilkinson, Tom M A

“…Respiratory diseases account for over 5 million deaths yearly and are a huge burden to healthcare systems worldwide. Murine models have been of paramount…”
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‘Watching what they can do on their own is beautiful’: A navigation of shared agency in school-based outdoor environmental education by Dean, S. N., Gilbert, A.

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ERS International Congress 2022: highlights from the Basic and Translational Science Assembly by Cuevas Ocaña, Sara, El-Merhie, Natalia, Kuipers, Merian E, Lehmann, Mareike, Enes, Sara Rolandsson, Voss, Carola, Dean, Lareb S N, Loxham, Matthew, Boots, Agnes W, Cloonan, Suzanne M, Greene, Catherine M, Heijink, Irene H, Joannes, Audrey, Mailleux, Arnaud A, Mansouri, Nahal, Reynaert, Niki L, van der Does, Anne M, Wagner, Darcy E, Ubags, Niki

“…In this review, the Basic and Translational Science Assembly of the European Respiratory Society provides an overview of the 2022 International Congress…”
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119 Differential Alveolar Toxicity of Exhaust and Non-Exhaust Fine Particulate Matter by Parkin, James, Dean, Lareb S N, Raj, Helen S V, Cooper, Dawn, Ridley, Robert, Davies, Elizabeth R, Conforti, Franco, Bell, Joseph A, Wang, Yihua, Downward, Julian, Cooper, Matthew J, Cassee, Flemming R, Davies, Donna E, Cook, Richard, Loxham, Matthew

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Tris(1,9-diethyl­adeninium) triiodide diiodide by Day, Elizabeth F., Dean, Norman S., Franz, Andreas H.

“…X‐ray analysis of the title compound reveals three crystallographically distinct cations of 1,9‐diethyl­adeninium, two iodide anions and one triiodide anion in…”
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Structure and Magnetism of Dibridged Vanadium(IV) Hydrotris(pyrazolyl)borate Dimers by Dean, Norman S, Bond, Marcus R, O'Connor, C. J, Carrano, Carl J

“…The synthesis and characterization of four dinuclear V(IV) complexes are described:  1, [LVO(μ-(Ph)2PO2)LVO]; 2, [LVO(μ-(Ph)HPO2)2LVO]; 3, [LVO(μ-OH)2LVO]; and…”
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Homo- and Heterometallic Mono-, Di-, and Trinuclear Co2+, Ni2+, Cu2+, and Zn2+ Complexes of the “Heteroscorpionate” Ligand (2-Hydroxyphenyl)bis(pyrazolyl)methane and Its Derivatives by Higgs, Timothy C, Dean, Norman S, Carrano, Carl J

“…1H NMR spectra on the paramagnetic CoII and NiII, ML2 “sandwich” complexes of the “heteroscorpionate” ligands (2-hydroxyphenyl)bis (pyrazolyl)methane and its…”
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[Tris(pyrazolyl)borato]vanadium(III) Phosphates:  Structural Motifs from the Extended Solid and Models for the Interaction with DNA by Dean, Norman S, Mokry, Ladd M, Bond, Marcus R, O'Connor, C. J, Carrano, Carl J

“…The syntheses of five mixed ligand vanadium(III) phosphate/phosphonate complexes are described:  dinuclear I, [LVCl{μ-(PhO)2PO2}]2; II, [LVCl{μ-Ph2PO2}]2; and…”
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Non-Template-Centered, Closed Tetravanadium Phosphate and Phosphonate Clusters by Otieno, Tom, Mokry, Ladd M, Bond, Marcus R, Carrano, Carl J, Dean, Norman S

“…Tetranuclear V(III) complexes, [HB(pz)3]4V4(μ-C6H5OPO3)4 (I), its acetonitrile solvate (I·4CH3CN), and [HB(pz)3]4V4(μ-O2NC6H4OPO3)4·4C7H8·H2O (II), and…”
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Vanadium Hydridotris(pyrazolyl)borate Complexes of Diphenyl Phosphate. Homometallic Trimeric Complexes of the [LV{(PhO)2PO2}3]- Fragment by Dean, Norman S, Mokry, Ladd M, Bond, Marcus R, O'Connor, C. J, Carrano, Carl J

“…The synthesis and characterization of two linear trinuclear V(III) complexes are described:  1, [LV(μ-(PhO)2PO2)3-V-(μ-(PhO)2PO2)3VL]PF6, and 2,…”
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Vanadium Hydrotris(pyrazolyl)borate Complexes of Diphenyl Phosphate. Heterometallic Complexes of the [LV{(PhO)2PO2}3 ] - Fragment by Dean, Norman S, Mokry, Ladd M, Bond, Marcus R, Mohan, Madan, Otieno, Tom, O'Connor, C. J, Spartalian, K, Carrano, Carl J

“…The synthesis and characterization of nine trinuclear, mixed metal complexes of the type [LV{μ-(PhO)2PO2}3]2M, where the vanadium is in the 3+ oxidation state,…”
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A Heterobimetallic Vanadium−Manganese Complex as a Model for the Structural Dynamics in Oxo-Bridged Metal Dimers by Dean, Norman S, Cooper, Jennifer K, Czernuszewicz, Roman S, Ji, David, Carrano, Carl J

“…The heterobimetallic complex 1, [LV(μ-O)(μ-OAc)2MnL] (where L = hydridotris(pyrazolyl)borate), has been synthesized and characterized. X-ray crystal structural…”
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Cables and equipment for cable systems by Dean, N.S.

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