Search Results - "Dean, Nicholas M."

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity by Graff, Jeremy R, Konicek, Bruce W, Vincent, Thomas M, Lynch, Rebecca L, Monteith, David, Weir, Spring N, Schwier, Phil, Capen, Andrew, Goode, Robin L, Dowless, Michele S, Chen, Yuefeng, Zhang, Hong, Sissons, Sean, Cox, Karen, McNulty, Ann M, Parsons, Stephen H, Wang, Tao, Sams, Lillian, Geeganage, Sandaruwan, Douglass, Larry E, Neubauer, Blake Lee, Dean, Nicholas M, Blanchard, Kerry, Shou, Jianyong, Stancato, Louis F, Carter, Julia H, Marcusson, Eric G

“…Expression of eukaryotic translation initiation factor 4E (eIF4E) is commonly elevated in human and experimental cancers, promoting angiogenesis and tumor…”
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MicroRNA-143 Regulates Adipocyte Differentiation by Esau, Christine, Kang, Xiaolin, Peralta, Eigen, Hanson, Elaine, Marcusson, Eric G, Ravichandran, Lingamanaidu V, Sun, Yingqing, Koo, Seongjoon, Perera, Ranjan J, Jain, Ravi, Dean, Nicholas M, Freier, Susan M, Bennett, C Frank, Lollo, Bridget, Griffey, Richard

“…MicroRNAs (miRNAs) are endogenously expressed 20-24 nucleotide RNAs thought to repress protein translation through binding to a target mRNA ( 1 - 3 ). Only a…”
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Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells by KIM, Youngsoo, JOON WON YOON, XIAOKUN XIAO, DEAN, Nicholas M, MONIA, Brett P, MARCUSSON, Eric G

“…The sonic hedgehog (Shh) pathway contributes to the initiation and progression of tumors with various origins when aberrantly activated. In this study, we…”
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Antisense inhibition of connective tissue growth factor (CTGF/CCN2) mRNA limits hypertrophic scarring without affecting wound healing in vivo by Sisco, Mark, Kryger, Zol B., O'Shaughnessy, Kristina D., Kim, Peter S., Schultz, Greg S., Ding, Xian-Zhong, Roy, Nakshatra K., Dean, Nicholas M., Mustoe, Thomas A.

“…ABSTRACT Augmented expression of connective tissue growth factor (CTGF/CCN2) is observed in healing wounds and in a variety of fibrotic disorders. It appears…”
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Competition for RISC binding predicts in vitro potency of siRNA by Koller, Erich, Propp, Stephanie, Murray, Heather, Lima, Walter, Bhat, Balkrishen, Prakash, Thaza P, Allerson, Charles R, Swayze, Eric E, Marcusson, Eric G, Dean, Nicholas M

“…Short interfering RNAs (siRNA) guide degradation of target RNA by the RNA-induced silencing complex (RISC). The use of siRNA in animals is limited partially…”
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Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation by Ali, Ambereen, Zhang, Ji, Bao, Shideng, Liu, Irene, Otterness, Diane, Dean, Nicholas M, Abraham, Robert T, Wang, Xiao-Fan

“…The checkpoint kinase ATM is centrally involved in the cellular response to DNA double-strand breaks. However, the mechanism of ATM activation during genotoxic…”
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Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice by BUTLER, Madeline, MCKAY, Robert A, POPOFF, Ian J, GAARDE, William A, WITCHELL, Donna, MURRAY, Susan F, DEAN, Nicholas M, BHANOT, Sanjay, MONIA, Brett P

“…Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice Madeline Butler , Robert A. McKay , Ian J. Popoff , William A. Gaarde , Donna…”
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Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis by Zhang, Hong, Cook, Jesse, Nickel, Jeffrey, Yu, Rosie, Stecker, Kimberly, Myers, Kathleen, Dean, Nicholas M

“…Aberrant apoptosis-mediated cell death is believed to result in a number of different human diseases. For example, excessive apoptosis in the liver can result…”
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Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2Aα by Bonness, Kathy, Aragon, Ileana V., Rutland, Beth, Ofori-Acquah, Solomon, Dean, Nicholas M., Honkanen, Richard E.

“…Cantharidin, a natural vesicant, inhibits the activity of several PPP family phosphatases, displays antitumor activity, and induces apoptosis in many types of…”
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Down-regulation of connective tissue growth factor and type I collagen mRNA expression by connective tissue growth factor antisense oligonucleotide during experimental liver fibrosis by Uchio, Kozue, Graham, Mark, Dean, Nicholas M., Rosenbaum, Jean, Desmoulière, Alexis

“…Transforming growth factor (TGF)‐β1 is a major mediator of liver fibrosis. Connective tissue growth factor (CTGF) mediates TGF‐β1 pro‐fibrogenic effects in…”
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Regulation and Targeting of Eg5, a Mitotic Motor Protein in Blast Crisis CML: Overcoming Imatinib Resistance by Carter, Bing Z., Mak, Duncan H., Shi, Yuexi, Schober, Wendy D, Wang, Rui-Yu, Konopleva, Marina, Koller, Erich, Dean, Nicholas M., Andreeff, Michael

“…Patients with blast crisis (BC) CML frequently become resistant to Imatinib, a Bcr-Abltyrosine kinase-targeting agent. Eg5, a microtubule-associated motor…”
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Identification of a Functional Link for the p53 Tumor Suppressor Protein in Dexamethasone-induced Growth Suppression by Urban, Gudrun, Golden, Teresa, Aragon, Ileana V, Cowsert, Lex, Cooper, Scott R, Dean, Nicholas M, Honkanen, Richard E

“…Serine/threonine phosphatase 5 (PP5) can act as a suppresser of p53-dependent growth suppression and has been reported to associate with several proteins,…”
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Inhibition of Antigen-Induced Eosinophilia and Late Phase Airway Hyperresponsiveness by an IL-5 Antisense Oligonucleotide in Mouse Models of Asthma by Karras, James G, McGraw, Kathy, McKay, Robert A, Cooper, Scott R, Lerner, Dmitri, Lu, Tao, Walker, Christoph, Dean, Nicholas M, Monia, Brett P

“…Chronic airway eosinophilia is associated with allergic asthma and is mediated in part by secretion of IL-5 from allergen-specific Th2 lymphocytes. IL-5 is a…”
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Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-xL is an essential survival protein of human myeloma cells by Derenne, Sophie, Monia, Brett, Dean, Nicholas M., Taylor, Jennifer K., Rapp, Marie-Josée, Harousseau, Jean-Luc, Bataille, Régis, Amiot, Martine

“…Multiple myeloma (MM) is a plasma cell malignancy that occurs mainly in bone marrow. As MM cells proliferate slowly, it would seem essential to find means of…”
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Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs by Sun, Yingqing, Koo, Seongjoon, White, Neill, Peralta, Eigen, Esau, Christine, Dean, Nicholas M., Perera, Ranjan J.

“…MicroRNAs (miRNAs) are believed to play important roles in developmental and other cellular processes by hybridizing to complementary target mRNA transcripts…”
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Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis by Vickers, Timothy A, Koo, Seongjoon, Bennett, C Frank, Crooke, Stanley T, Dean, Nicholas M, Baker, Brenda F

“…RNA interference can be considered as an antisense mechanism of action that utilizes a double-stranded RNase to promote hydrolysis of the target RNA. We have…”
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Antisense oligonucleotide-based therapeutics for cancer by Dean, Nicholas M, Bennett, C Frank

“…There has been steady progress in antisense technology over the past 14 years. We now have a far better appreciation of the attributes and limitations of the…”
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Pharmacologic inhibition of RAF→MEK→ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1 by GYSIN, Stephan, LEE, Sang-Hyun, DEAN, Nicholas M, MCMAHON, Martin

“…Expression of mutationally activated RAS is a feature common to the vast majority of human pancreatic adenocarcinomas. RAS elicits its effects through numerous…”
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Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling by Dean, D A, Urban, G, Aragon, I V, Swingle, M, Miller, B, Rusconi, S, Bueno, M, Dean, N M, Honkanen, R E

“…In most cells glucocorticoid receptors (GR) reside predominantly in the cytoplasm. Upon hormone binding, the GR translocates into the nucleus, where the…”
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Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death by Theobald, Benjamin, Bonness, Kathy, Musiyenko, Alla, Andrews, Joel F, Urban, Gudrun, Huang, Xizhong, Dean, Nicholas M, Honkanen, Richard E

“…Fostriecin is a natural product purified from Sterptomyces extracts with antitumor activity sufficient to warrant human clinical trials. Unfortunately,…”
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