Search Results - "Dean, Jeffry"

Modification of the DNA Damage Response by Therapeutic CDK4/6 Inhibition by Dean, Jeffry L., McClendon, A.Kathleen, Knudsen, Erik S.

“…The RB/E2F axis represents a critical node of cell signaling that integrates a diverse array of signaling pathways. Recent evidence has suggested a role for…”
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A hormone-DNA repair circuit governs the response to genotoxic insult by Goodwin, Jonathan F, Schiewer, Matthew J, Dean, Jeffry L, Schrecengost, Randy S, de Leeuw, Renée, Han, Sumin, Ma, Teng, Den, Robert B, Dicker, Adam P, Feng, Felix Y, Knudsen, Karen E

“…Alterations in DNA repair promote tumor development, but the impact on tumor progression is poorly understood. Here, discovery of a biochemical circuit linking…”
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Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors by Dean, Jeffry L., McClendon, A. Kathleen, Hickey, Theresa E., Butler, Lisa M., Tilley, Wayne D., Witkiewicz, Agnieszka K., Knudsen, Erik S.

“…To model the heterogeneity of breast cancer as observed in the clinic, we employed an ex vivo model of breast tumor tissue. This methodology maintained the…”
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Harmonization of transcriptomic and methylomic analysis in environmental epidemiology studies for potential application in chemical risk assessment by Kim, Stephanie, White, Shana M., Radke, Elizabeth G., Dean, Jeffry L.

“…Recent efforts have posited the utility of transcriptomic-based approaches to understand chemical-related perturbations in the context of human health risk…”
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Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer by Thangavel, Chellappagounder, Dean, Jeffry L, Ertel, Adam, Knudsen, Karen E, Aldaz, C Marcelo, Witkiewicz, Agnieszka K, Clarke, Robert, Knudsen, Erik S

“…The majority of estrogen receptor (ER)-positive breast cancers are treated with endocrine therapy. While this is effective, acquired resistance to therapies…”
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Dual roles of PARP-1 promote cancer growth and progression by Schiewer, Matthew J, Goodwin, Jonathan F, Han, Sumin, Brenner, J Chad, Augello, Michael A, Dean, Jeffry L, Liu, Fengzhi, Planck, Jamie L, Ravindranathan, Preethi, Chinnaiyan, Arul M, McCue, Peter, Gomella, Leonard G, Raj, Ganesh V, Dicker, Adam P, Brody, Jonathan R, Pascal, John M, Centenera, Margaret M, Butler, Lisa M, Tilley, Wayne D, Feng, Felix Y, Knudsen, Karen E

“…PARP-1 is an abundant nuclear enzyme that modifies substrates by poly(ADP-ribose)-ylation. PARP-1 has well-described functions in DNA damage repair and also…”
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RB Loss Promotes Prostate Cancer Metastasis by Thangavel, Chellappagounder, Boopathi, Ettickan, Liu, Yi, Haber, Alex, Ertel, Adam, Bhardwaj, Anshul, Addya, Sankar, Williams, Noelle, Ciment, Stephen J, Cotzia, Paolo, Dean, Jeffry L, Snook, Adam, McNair, Chris, Price, Matt, Hernandez, James R, Zhao, Shuang G, Birbe, Ruth, McCarthy, James B, Turley, Eva A, Pienta, Kenneth J, Feng, Felix Y, Dicker, Adam P, Knudsen, Karen E, Den, Robert B

“…RB loss occurs commonly in neoplasia but its contributions to advanced cancer have not been assessed directly. Here we show that RB loss in multiple murine…”
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CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy by McClendon, A. Kathleen, Dean, Jeffry L., Rivadeneira, Dayana B., Yu, Justine E., Reed, Christopher A., Gao, Erhe, Farber, John L., Force, Thomas, Koch, Walter J., Knudsen, Erik S.

“…Triple-negative breast cancer (TNBC) is an aggressive disease that lacks established markers to direct therapeutic intervention. Thus, these tumors are…”
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Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods by Lizarraga, Lucina E., Suter, Glenn W., Lambert, Jason C., Patlewicz, Grace, Zhao, Jay Q., Dean, Jeffry L., Kaiser, Phillip

“…The assessment of human health hazards posed by chemicals traditionally relies on toxicity studies in experimental animals. However, most chemicals currently…”
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RB-pathway disruption in breast cancer: Differential association with disease subtypes, disease-specific prognosis and therapeutic response by Ertel, Adam, Dean, Jeffry L., Rui, Hallgeir, Liu, Chengbao, Witkiewicz, Agnes, Knudsen, Karen E., Knudsen, Erik S.

“…In breast cancer, inactivation of the RB tumor suppressor gene is believed to occur via multiple mechanisms to facilitate tumorigenesis.  However, the…”
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USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression by SCHRECENGOST, Randy S, DEAN, Jeffry L, VISAKORPI, Tapio, DEMARZO, Angelo M, MCMAHON, Steven B, KNUDSEN, Karen E, GOODWIN, Jonathan F, SCHIEWER, Matthew J, URBAN, Mark W, STANEK, Timothy J, SUSSMAN, Robyn T, HICKS, Jessica L, BIRBE, Ruth C, DRAGANOVA-TACHEVA, Rossitza A

“…Increasing evidence links deregulation of the ubiquitin-specific proteases 22 (USP22) deubitiquitylase to cancer development and progression in a select group…”
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DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis by Goodwin, Jonathan F., Kothari, Vishal, Drake, Justin M., Zhao, Shuang, Dylgjeri, Emanuela, Dean, Jeffry L., Schiewer, Matthew J., McNair, Christopher, Jones, Jennifer K., Aytes, Alvaro, Magee, Michael S., Snook, Adam E., Zhu, Ziqi, Den, Robert B., Birbe, Ruth C., Gomella, Leonard G., Graham, Nicholas A., Vashisht, Ajay A., Wohlschlegel, James A., Graeber, Thomas G., Karnes, R. Jeffrey, Takhar, Mandeep, Davicioni, Elai, Tomlins, Scott A., Abate-Shen, Cory, Sharifi, Nima, Witte, Owen N., Feng, Felix Y., Knudsen, Karen E.

“…Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent roles in transcriptional regulation of unsolved consequence. Here, in vitro…”
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A case study on the application of an expert-driven read-across approach in support of quantitative risk assessment of p,p’-dichlorodiphenyldichloroethane by Lizarraga, Lucina E., Dean, Jeffry L., Kaiser, J. Phillip, Wesselkamper, Scott C., Lambert, Jason C., Zhao, Q. Jay

“…Deriving human health risk estimates for environmental chemicals has traditionally relied on in vivo toxicity databases to characterize potential adverse…”
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The role of tumor suppressor dysregulation in prostate cancer progression by Dean, Jeffry L, Knudsen, Karen E

“…Androgen receptor activity is essential for prostate cancer development and progression. While there are classically defined roles for the retinoblastoma (Rb)…”
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Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes by Augello, Michael A, Burd, Craig J, Birbe, Ruth, McNair, Christopher, Ertel, Adam, Magee, Michael S, Frigo, Daniel E, Wilder-Romans, Kari, Shilkrut, Mark, Han, Sumin, Jernigan, Danielle L, Dean, Jeffry L, Fatatis, Alessandro, McDonnell, Donald P, Visakorpi, Tapio, Feng, Felix Y, Knudsen, Karen E

“…Cyclin D1b is a splice variant of the cell cycle regulator cyclin D1 and is known to harbor divergent and highly oncogenic functions in human cancer. While…”
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Consequence of the tumor‐associated conversion to cyclin D1b by Augello, Michael A, Berman‐Booty, Lisa D, Carr, Richard, Yoshida, Akihiro, Dean, Jeffry L, Schiewer, Matthew J, Feng, Felix Y, Tomlins, Scott A, Gao, Erhe, Koch, Walter J, Benovic, Jeffrey L, Diehl, John Alan, Knudsen, Karen E

“…Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular…”
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Integrating publicly available information to screen potential candidates for chemical prioritization under the Toxic Substances Control Act: A proof of concept case study using genotoxicity and carcinogenicity by Patlewicz, Grace, Dean, Jeffry L., Gibbons, Catherine F., Judson, Richard S., Keshava, Nagalakshmi, Vegosen, Leora, Martin, Todd M., Pradeep, Prachi, Simha, Anita, Warren, Sarah H., Gwinn, Maureen R., DeMarini, David M.

“…•TSCA requires the U.S. EPA to perform risk-based evaluations of existing chemicals.•Developed tiered approach to screen for genotoxicity and…”
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RB and p53 Cooperate to Prevent Liver Tumorigenesis in Response to Tissue Damage by McClendon, A. Kathleen, Dean, Jeffry L, Ertel, Adam, Fu, Zhiyan, Rivadeneira, Dayana B, Reed, Christopher A, Bourgo, Ryan J, Witkiewicz, Agnieszka, Addya, Sankar, Mayhew, Christopher N, Grimes, H. Leighton, Fortina, Paolo, Knudsen, Erik S

“…Background & Aims The tumor suppressors retinoblastoma (RB) and p53 are important regulators of the cell cycle. Although human cancer cells inactivate RB and…”
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Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists by Wang, Ying, Dean, Jeffry L, Millar, Ewan K A, Tran, Thai Hong, McNeil, Catriona M, Burd, Craig J, Henshall, Susan M, Utama, Fransiscus E, Witkiewicz, Agnieszka, Rui, Hallgeir, Sutherland, Robert L, Knudsen, Karen E, Knudsen, Erik S

“…Cyclin D1 is a key mediator of cell cycle progression that is aberrantly regulated in multiple cancers, especially in breast cancers. A number of studies have…”
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Differential impact of tumor suppressor pathways on DNA damage response and therapy-induced transformation in a mouse primary cell model by McClendon, A Kathleen, Dean, Jeffry L, Ertel, Adam, Knudsen, Erik S

“…The RB and p53 tumor suppressors are mediators of DNA damage response, and compound inactivation of RB and p53 is a common occurrence in human cancers…”
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