Search Results - "Dean, Gregg A"

Impact of oral probiotic Lactobacillus acidophilus vaccine strains on the immune response and gut microbiome of mice by Abdo, Zaid, LeCureux, Jonathan, LaVoy, Alora, Eklund, Bridget, Ryan, Elizabeth P, Dean, Gregg A

“…The potential role of probiotic bacteria as adjuvants in vaccine trials led to their use as nonparenteral live mucosal vaccine vectors. Yet, interactions…”
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Mucosal Immunogenicity of Genetically Modified Lactobacillus acidophilus Expressing an HIV-1 Epitope within the Surface Layer Protein by Kajikawa, Akinobu, Zhang, Lin, LaVoy, Alora, Bumgardner, Sara, Klaenhammer, Todd R, Dean, Gregg A

“…Surface layer proteins of probiotic lactobacilli are theoretically efficient epitope-displaying scaffolds for oral vaccine delivery due to their high…”
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Adjuvant Strategies for Lactic Acid Bacterial Mucosal Vaccines by Vilander, Allison C, Dean, Gregg A

“…Lactic acid bacteria (LAB) are Gram-positive, acid-tolerant bacteria that have long been used in food fermentation and are generally recognized as safe (GRAS)…”
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Expression of E. coli FimH Enhances Trafficking of an Orally Delivered Lactobacillus acidophilus Vaccine to Immune Inductive Sites via Antigen-Presenting Cells by Vilander, Allison C, Shelton, Kimberly, LaVoy, Alora, Dean, Gregg A

“…The development of lactic acid bacteria as mucosal vaccine vectors requires the identification of robust mucosal adjuvants to increase vaccine effectiveness…”
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An Aptamer-Based Proteomic Analysis of Plasma from Cats ( Felis catus ) with Clinical Feline Infectious Peritonitis by Curtis, Benjamin E, Abdo, Zaid, Graham, Barbara, LaVoy, Alora, Evans, Samantha J M, Santangelo, Kelly, Dean, Gregg A

“…Feline infectious peritonitis (FIP) is a systemic disease manifestation of feline coronavirus (FCoV) and is the most important cause of infectious…”
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Nod2 is required for antigen-specific humoral responses against antigens orally delivered using a recombinant Lactobacillus vaccine platform by Bumgardner, Sara A, Zhang, Lin, LaVoy, Alora S, Andre, Barbara, Frank, Chad B, Kajikawa, Akinobu, Klaenhammer, Todd R, Dean, Gregg A

“…Safe and efficacious orally-delivered mucosal vaccine platforms are desperately needed to combat the plethora of mucosally transmitted pathogens. Lactobacillus…”
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Host Functional Response to a Prototypic Orally Delivered Self-Replicating Vaccine Platform by Vilander, Allison C, Burak, Julia, Gilfillan, Darby, Dean, Gregg A, Abdo, Zaid

“…The development of mucosal vaccines has been limited and could be aided by a systems vaccinology approach to identify platforms and adjuvant strategies that…”
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Oral Vaccination Using a Probiotic Vaccine Platform Combined with Prebiotics Impacts Immune Response and the Microbiome by Fox, Bridget E, Vilander, Allison C, Gilfillan, Darby, Dean, Gregg A, Abdo, Zaid

“…Unique to mucosal vaccination is the reciprocal influence of the microbiome and mucosal immune responses, where the immune system is constantly balancing…”
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Effects of Regulatory T Cell Depletion on NK Cell Responses against Listeria monocytogenes in Feline Immunodeficiency Virus Infected Cats by Simões, Rita D, LaVoy, Alora, Dean, Gregg A

“…Regulatory T cells (Treg) are key players in the maintenance of peripheral tolerance, preventing autoimmune diseases and restraining chronic inflammatory…”
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Mucosal Immune Response to Feline Enteric Coronavirus Infection by Pearson, Morgan, LaVoy, Alora, Evans, Samantha, Vilander, Allison, Webb, Craig, Graham, Barbara, Musselman, Esther, LeCureux, Jonathan, VandeWoude, Sue, Dean, Gregg A

“…Feline infectious peritonitis is a devastating, fatal disease of domestic cats caused by a pathogenic mutant virus derived from the ubiquitous feline enteric…”
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Lactobacillus acidophilus Expressing Murine Rotavirus VP8 and Mucosal Adjuvants Induce Virus-Specific Immune Responses by Gilfillan, Darby, Vilander, Allison C, Pan, Meichen, Goh, Yong Jun, O'Flaherty, Sarah, Feng, Ningguo, Fox, Bridget E, Lang, Callie, Greenberg, Harry B, Abdo, Zaid, Barrangou, Rodolphe, Dean, Gregg A

“…Rotavirus diarrhea-associated illness remains a major cause of global death in children under five, attributable in part to discrepancies in vaccine…”
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Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector by Stoeker, Laura, Nordone, Shila, Gunderson, Sara, Zhang, Lin, Kajikawa, Akinobu, LaVoy, Alora, Miller, Michael, Klaenhammer, Todd R, Dean, Gregg A

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Dissimilar Properties of Two Recombinant Lactobacillus acidophilus Strains Displaying Salmonella FliC with Different Anchoring Motifs by KAJIKAWA, Akinobu, NORDONE, Shila K, LIN ZHANG, STOEKER, Laura L, LAVOY, Alora S, KLAENHAMMER, Todd R, DEAN, Gregg A

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms by Takaesu, Giichi, Inagaki, Maiko, Takubo, Keiyo, Mishina, Yuji, Hess, Paul R, Dean, Gregg A, Yoshimura, Akihiko, Matsumoto, Kunihiro, Suda, Toshio, Ninomiya-Tsuji, Jun

“…A cytokine/stress signaling kinase Tak1 (Map3k7) deficiency is known to impair hematopoietic progenitor cells. However, the role of TAK1 signaling in the stem…”
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A novel candidate vaccine for cytauxzoonosis inferred from comparative apicomplexan genomics by Tarigo, Jaime L, Scholl, Elizabeth H, McK Bird, David, Brown, Corrie C, Cohn, Leah A, Dean, Gregg A, Levy, Michael G, Doolan, Denise L, Trieu, Angela, Nordone, Shila K, Felgner, Philip L, Vigil, Adam, Birkenheuer, Adam J

“…Cytauxzoonosis is an emerging infectious disease of domestic cats (Felis catus) caused by the apicomplexan protozoan parasite Cytauxzoon felis. The growing…”
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In vivo assessment of natural killer cell responses during chronic feline immunodeficiency virus infection by Simões, Rita D, Howard, Kristina E, Dean, Gregg A

“…Accumulating evidence suggests that natural killer (NK) cells may have an important role in HIV-1 disease pathogenesis; however, in vivo studies are lacking…”
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Review: The PI3K-AKT-mTOR signal transduction pathway in canine cancer by Meuten, Travis K., Dean, Gregg A., Thamm, Douglas H.

“…Tumors in dogs and humans share many similar molecular and genetic features, incentivizing a better understanding of canine neoplasms not only for the purpose…”
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Partial regulatory T cell depletion prior to acute feline immunodeficiency virus infection does not alter disease pathogenesis by Mikkelsen, S Rochelle, Long, Julie M, Zhang, Lin, Galemore, Erin R, VandeWoude, Sue, Dean, Gregg A

“…Feline immunodeficiency virus (FIV) infection in cats follows a disease course similar to HIV-1, including a short acute phase characterized by high viremia,…”
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Lactobacillus Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens by LeCureux, Jonathan S, Dean, Gregg A

“…Lactic acid bacteria (LAB) have been utilized since the 1990s for therapeutic heterologous gene expression. The ability of LAB to elicit an immune response…”
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High-throughput viral microneutralization method for feline coronavirus using image cytometry by Pearson, Morgan, LaVoy, Alora, Chan, Leo Li-Ying, Dean, Gregg A.

“…•There are no approved antiviral drugs or recommended vaccines for feline coronavirus infection.•Plate-based image cytometry is used for high-throughput viral…”
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