Search Results - "Dean, Angela E."

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter by Zhu, Yueming, Zou, Xianghui, Dean, Angela E., Brien, Joseph O’, Gao, Yucheng, Tran, Elizabeth L., Park, Seong-Hoon, Liu, Guoxiang, Kieffer, Matthew B., Jiang, Haiyan, Stauffer, Melissa E., Hart, Robert, Quan, Songhua, Satchell, Karla J. F., Horikoshi, Nobuo, Bonini, Marcelo, Gius, David

“…Manganese superoxide dismutase (MnSOD) functions as a tumor suppressor; however, once tumorigenesis occurs, clinical data suggest MnSOD levels correlate with…”
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Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice by Quan, Songhua, Principe, Daniel R., Dean, Angela E., Park, Seong-Hoon, Grippo, Paul J., Gius, David, Horikoshi, Nobuo

“…Mice lacking Sirt2 spontaneously develop tumors in multiple organs, as well as when expressed in combination with oncogenic Kras G12D , leading to pancreatic…”
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Fxr-alpha Skips Alternatively in Liver Metabolism by Anakk, Sayeepriyadarshini, Dean, Angela E.

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Sex differences feed into nuclear receptor signaling along the digestive tract by Dean, Angela E, Reichardt, François, Anakk, Sayeepriyadarshini

“…Sex differences in physiology are noted in clinical and animal studies. However, mechanisms underlying these observed differences between males and females…”
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Hepatic farnesoid X receptor is necessary to facilitate ductular reaction and expression of heme biosynthetic genes by Dean, Angela E, Jungwirth, Emilian, Panzitt, Katrin, Wagner, Martin, Anakk, Sayeepriyadarshini

“…Bile, which contains bile acids, the natural ligands for farnesoid x receptor (FXR), moves from the liver to the intestine through bile ducts. Ductular…”
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MnSOD Lysine 68 acetylation leads to cisplatin and doxorubicin resistance due to aberrant mitochondrial metabolism by Gao, Yucheng, Zhu, Yueming, Tran, Elizabeth L, Tokars, Valerie, Dean, Angela E, Quan, Songhua, Gius, David

“…Manganese superoxide dismutase (MnSOD) acetylation (Ac) has been shown to be a key post-translational modification important in the regulation of…”
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SAT018 Investigate If Sex Differences In Microbiota Is Sufficient To Promote Bile Acid-Mediated Hepatocellular Carcinoma In Mice by Dean, Angela E, Gaulke, Christopher A, Anakk, Sayeepriyadarshini

“…Abstract Disclosure: A.E. Dean: None. S. Anakk: None. Liver cancer is one of the leading causes of cancer-related deaths with men having a higher prevalence…”
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SAT007 Excess Bile Acids Can Compensate To Promote Regeneration In Constitutive Androstane Receptor Knockout Mice by Zhou, Weinan, Chembazhi, Ullas V, Huang, Jiansheng, Bangru, Sushant, Dean, Angela E, Kalsotra, Auinash, Rudnick, David A, Anakk, Sayeepriyadarshini

“…Abstract Disclosure: W. Zhou: None. U.V. Chembazhi: None. J. Huang: None. S. Bangru: None. A.E. Dean: None. A. Kalsotra: None. D.A. Rudnick: None. S. Anakk:…”
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Investigating the Role of Farnesoid X Receptor in Heme Biosynthesis and Ductular Reaction by Dean, Angela E, Jungwirth, Emilian, Panzitt, Katrin, Wagner, Martin, Anakk, Sayeepriyadarshini

“…Abstract Bile acids (BAs) have gained traction not just as emulsifiers of fat, but also as hormones. Nuclear receptor Farnesoid X receptor (FXR) is the master…”
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