Search Results - "Deak, D."

Multisection CT Protocols: Sex- and Age-specific Conversion Factors Used to Determine Effective Dose from Dose-Length Product by DEAK, Paul D, SMAL, Yulia, KALENDER, Willi A

“…To determine conversion factors for the new International Commission on Radiological Protection (ICRP) publication 103 recommendations for adult and pediatric…”
Get full text

Isotretinoin is indirectly effective in sebocytes by Kovács, D., Hegyi, K., Szegedi, A., Deák, D., Póliska, Sz, Rühl, R., Zouboulis, C.C., Törőcsik, D.

Get full text

Effects of adaptive section collimation on patient radiation dose in multisection spiral CT by Deak, Paul D, Langner, Oliver, Lell, Michael, Kalender, Willi A

“…To evaluate the potential effectiveness of adaptive collimation in reducing computed tomographic (CT) radiation dose owing to z-overscanning by using dose…”
Get full text

Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration by Austin-Zimmerman, Isabelle, Levey, Daniel F., Giannakopoulou, Olga, Deak, Joseph D., Galimberti, Marco, Adhikari, Keyrun, Zhou, Hang, Denaxas, Spiros, Irizar, Haritz, Kuchenbaecker, Karoline, McQuillin, Andrew, Concato, John, Buysse, Daniel J., Gaziano, J. Michael, Gottlieb, Daniel J., Polimanti, Renato, Stein, Murray B., Bramon, Elvira, Gelernter, Joel

“…Sleep duration has been linked to a wide range of negative health outcomes and to reduced life expectancy. We present genome-wide association studies of short…”
Get full text

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals by Zhou, Hang, Kember, Rachel L., Deak, Joseph D., Xu, Heng, Toikumo, Sylvanus, Yuan, Kai, Lind, Penelope A., Farajzadeh, Leila, Wang, Lu, Hatoum, Alexander S., Johnson, Jessica, Lee, Hyunjoon, Mallard, Travis T., Xu, Jiayi, Johnston, Keira J. A., Johnson, Emma C., Nielsen, Trine Tollerup, Galimberti, Marco, Dao, Cecilia, Levey, Daniel F., Overstreet, Cassie, Byrne, Enda M., Gillespie, Nathan A., Gordon, Scott, Hickie, Ian B., Whitfield, John B., Xu, Ke, Zhao, Hongyu, Huckins, Laura M., Davis, Lea K., Sanchez-Roige, Sandra, Madden, Pamela A. F., Heath, Andrew C., Medland, Sarah E., Martin, Nicholas G., Ge, Tian, Smoller, Jordan W., Hougaard, David M., Børglum, Anders D., Demontis, Ditte, Krystal, John H., Gaziano, J. Michael, Edenberg, Howard J., Agrawal, Arpana, Justice, Amy C., Stein, Murray B., Kranzler, Henry R., Gelernter, Joel

“…Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of…”
Get full text

Association patterns of antisocial personality disorder across substance use disorders by Low, Aislinn, Stiltner, Brendan, Nunez, Yaira Z., Adhikari, Keyrun, Deak, Joseph D., Pietrzak, Robert H., Kranzler, Henry R., Gelernter, Joel, Polimanti, Renato

“…There is a high prevalence of antisocial personality disorder (ASPD) in individuals affected by substance use disorders (SUD). However, there is limited…”
Get full text

Polygenic scores for smoking and educational attainment have independent influences on academic success and adjustment in adolescence and educational attainment in adulthood by Hicks, Brian M, Clark, D Angus, Deak, Joseph D, Schaefer, Jonathan D, Liu, Mengzhen, Jang, Seonkyeong, Durbin, C Emily, Johnson, Wendy, Wilson, Sylia, Iacono, William G, McGue, Matt, Vrieze, Scott I

“…Educational success is associated with greater quality of life and depends, in part, on heritable cognitive and non-cognitive traits. We used polygenic scores…”
Get full text

Using Local and Global Genetic Correlation Approaches to Help Elucidate the Shared Genetic Etiology of Psychiatric and Substance Use Traits by Deak, Joseph D.

Get full text

Genetics of substance use disorders: a review by Deak, Joseph D, Johnson, Emma C

“…Substance use disorders (SUDs) are prevalent and result in an array of negative consequences. They are influenced by genetic factors (h2 = ~50%). Recent years…”
Get more information

What Are the Genetic Building Blocks of Alcohol-Related Behaviors? by Gelernter, Joel, Deak, Joseph D

“…Alcohol use is prevalent in society and can lead to various problems. Different individuals have different reasons for using alcohol and experience its effects…”
Get full text

Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits by Galimberti, Marco, Levey, Daniel F., Deak, Joseph D., Zhou, Hang, Stein, Murray B., Gelernter, Joel

“…Cannabis use disorder (CanUD) has increased with the legalization of the use of cannabis. Around 20% of individuals using cannabis develop CanUD, and the…”
Get full text

The relationship between cannabis and schizophrenia: a genetically informed perspective by Johnson, Emma C., Hatoum, Alexander S., Deak, Joseph D., Polimanti, Renato, Murray, Robin M., Edenberg, Howard J., Gelernter, Joel, Di Forti, Marta, Agrawal, Arpana

“…Background and Aims While epidemiological studies support a role for heavy, high‐potency cannabis use on first‐episode psychosis, genetic models of causation…”
Get full text

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci by Deak, Joseph D., Zhou, Hang, Galimberti, Marco, Levey, Daniel F., Wendt, Frank R., Sanchez-Roige, Sandra, Hatoum, Alexander S., Johnson, Emma C., Nunez, Yaira Z., Demontis, Ditte, Børglum, Anders D., Rajagopal, Veera M., Jennings, Mariela V., Kember, Rachel L., Justice, Amy C., Edenberg, Howard J., Agrawal, Arpana, Polimanti, Renato, Kranzler, Henry R., Gelernter, Joel

“…Despite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS) of OUD to date have yielded few susceptibility loci. We performed a…”
Get full text

Associations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin study by Schaefer, Jonathan D, Jang, Seon-Kyeong, Clark, D Angus, Deak, Joseph D, Hicks, Brian M, Iacono, William G, Liu, Mengzhen, McGue, Matt, Vrieze, Scott I, Wilson, Sylia

“…Recent well-powered genome-wide association studies have enhanced prediction of substance use outcomes via polygenic scores (PGSs). Here, we test (1) whether…”
Get more information

Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder by Wendt, Frank R., Pathak, Gita A., Deak, Joseph D., De Angelis, Flavio, Koller, Dora, Cabrera-Mendoza, Brenda, Lebovitch, Dannielle S., Levey, Daniel F., Stein, Murray B., Kranzler, Henry R., Koenen, Karestan C., Gelernter, Joel, Huckins, Laura M., Polimanti, Renato

“…UK Biobank (UKB) is a key contributor in mental health genome-wide association studies (GWAS) but only ~31% of participants completed the Mental Health…”
Get full text

Genome-wide analyses reveal shared genetic architecture and novel risk loci between opioid use disorder and general cognitive ability by Holen, Børge, Kutrolli, Gleda, Shadrin, Alexey A., Icick, Romain, Hindley, Guy, Rødevand, Linn, O’Connell, Kevin S., Frei, Oleksandr, Parker, Nadine, Tesfaye, Markos, Deak, Joseph D., Jahołkowski, Piotr, Dale, Anders M., Djurovic, Srdjan, Andreassen, Ole A., Smeland, Olav B.

“…Opioid use disorder (OUD), a serious health burden worldwide, is associated with lower cognitive function. Recent studies have demonstrated a negative genetic…”
Get full text

Genetics of alcohol use disorder: a review by Deak, Joseph D, Miller, Alex P, Gizer, Ian R

“…Alcohol use disorder (AUD) represents a significant and ongoing public health concern with 12-month prevalence estimates of ∼5.6%. Quantitative genetic studies…”
Get full text

Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study by Xu, Heng, Toikumo, Sylvanus, Crist, Richard C., Glogowska, Klaudia, Jinwala, Zeal, Deak, Joseph D., Justice, Amy C., Gelernter, Joel, Johnson, Emma C., Kranzler, Henry R., Kember, Rachel L.

“…Background and Aims Genome‐wide association studies (GWAS) of opioid use disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use…”
Get full text

Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders by Koller, Dora, Friligkou, Eleni, Stiltner, Brendan, Pathak, Gita A., Løkhammer, Solveig, Levey, Daniel F., Zhou, Hang, Hatoum, Alexander S., Deak, Joseph D., Kember, Rachel L., Treur, Jorien L., Kranzler, Henry R., Johnson, Emma C., Stein, Murray B., Gelernter, Joel, Polimanti, Renato

“…Individuals suffering from chronic pain develop substance use disorders (SUDs) more often than others. Understanding the shared genetic influences underlying…”
Get full text

Alcohol and nicotine polygenic scores are associated with the development of alcohol and nicotine use problems from adolescence to young adulthood by Deak, Joseph D., Clark, D. Angus, Liu, Mengzhen, Schaefer, Jonathan D., Jang, Seon Kyeong, Durbin, C. Emily, Iacono, William G., McGue, Matt, Vrieze, Scott, Hicks, Brian M.

“…Background and Aims Molecular genetic studies of alcohol and nicotine use have identified many genome‐wide association study (GWAS) loci. We measured…”
Get full text