Search Results - "Deahl, J. Thom"

In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances by Bercu, Joel P., Morton, Stuart M., Deahl, J. Thom, Gombar, Vijay K., Callis, Courtney M., van Lier, Robert B.L.

“…The current risk assessment approach for addressing the safety of very small concentrations of genotoxic impurities (GTIs) in drug substances is the threshold…”
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Relationships between genomic, cell cycle, and mutagenic responses of TK6 cells exposed to DNA damaging chemicals by Islaih, Mohammed, Halstead, Bartley W, Kadura, Ibrahim A, Li, Baohui, Reid-Hubbard, Jaclyn L, Flick, Leah, Altizer, Julie L, Thom Deahl, J, Monteith, David K, Newton, Ronald K, Watson, David E

“…Genotoxic stress causes a variety of cellular and molecular responses in mammalian cells, including cell cycle arrest, DNA repair, and apoptosis. These…”
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Comparison of gene expression changes induced in mouse and human cells treated with direct-acting mutagens by Islaih, Mohammed, Li, Baohui, Kadura, Ibrahim A., Reid-Hubbard, Jaclyn L., Deahl, J. Thom, Altizer, Julie L., Watson, David E., Newton, Ronald K.

“…Exposure to DNA‐damaging agents can elicit a variety of stress‐related responses that may alter the gene expression of numerous biological pathways. We used…”
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Mutagenicity of Photodynamic Therapy as Compared to UVC and Ionizing Radiation in Human and Murine Lymphoblast Cell Lines by Evans, Helen H., Horng, Min-Fen, Ricanati, Marlene, Deahl, J. Thorn, Oleinick, Nancy L.

“…— The mutagenicity of photodynamic therapy (PDT) using red light and either Photofrin® (porfimer sodium) (PF) or aluminum phthalocyanine (AIPc) as the…”
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Variation in Photodynamic Efficacy during the Cellular Uptake of Two Phthalocyanine Photosensitizers by He, Jin, Horng, Min-Fen, Deahl, J. Thom, Oleinick, Nancy L., Evans, Helen H.

“…ABSTRACT A decrease in the efficacy of photodynamic therapy (PDT) with phthalocyanine photosensitizers was observed for lymphoblastic murine and human cell…”
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Variation in photodynamic efficacy during the cellular uptake of two phthalocyanine photosensitizers by He, J, Horng, M F, Deahl, J T, Oleinick, N L, Evans, H H

“…A decrease in the efficacy of photodynamic therapy (PDT) with phthalocyanine photosensitizers was observed for lymphoblastic murine and human cell lines as the…”
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Large mutagenic lesions are induced by photodynamic therapy in murine L5178Y lymphoblasts by Deahl, J T, Oleinick, N L, Evans, H H

“…Mutagenic lesions at the thymidine kinase locus (tk) in mouse lymphoma L5178Y (LY) cells treated with red light and either Photofrin (PF) or chloroaluminum…”
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Activity of 1,1,1- and 1,1,3-trichloroacetones in a chromosomal aberration assay in CHO cells and the micronucleus and spermhead abnormality assays in mice by Blazak, W F, Meier, J R, Stewart, B E, Blachman, D C, Deahl, J T

“…1,1,1- and 1,1,3-trichloroacetones (TCA) result from the disinfection of municipal water supplies with chlorine, and are direct-acting mutagens in the…”
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