Search Results - "Deadwyler, Sam A"
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Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates
Published in The Journal of neuroscience (26-12-2007)“…Hypocretin-1 (orexin-A) was administered to sleep-deprived (30-36 h) rhesus monkeys immediately preceding testing on a multi-image delayed match-to-sample…”
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Sparse Large-Scale Nonlinear Dynamical Modeling of Human Hippocampus for Memory Prostheses
Published in IEEE transactions on neural systems and rehabilitation engineering (01-02-2018)“…In order to build hippocampal prostheses for restoring memory functions, we build sparse multi-input, multi-output (MIMO) nonlinear dynamical models of the…”
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A Hippocampal Cognitive Prosthesis: Multi-Input, Multi-Output Nonlinear Modeling and VLSI Implementation
Published in IEEE transactions on neural systems and rehabilitation engineering (01-03-2012)“…This paper describes the development of a cognitive prosthesis designed to restore the ability to form new long-term memories typically lost after damage to…”
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Columnar processing in primate pFC: evidence for executive control microcircuits
Published in Journal of cognitive neuroscience (01-12-2012)“…A common denominator for many cognitive disorders of human brain is the disruption of neural activity within pFC, whose structural basis is primarily…”
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Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank
Published in Frontiers in neuroscience (24-01-2018)“…The annual Deep Brain Stimulation (DBS) Think Tank provides a focal opportunity for a multidisciplinary ensemble of experts in the field of neuromodulation to…”
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Identification of sparse neural functional connectivity using penalized likelihood estimation and basis functions
Published in Journal of computational neuroscience (01-12-2013)“…One key problem in computational neuroscience and neural engineering is the identification and modeling of functional connectivity in the brain using spike…”
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Patterned Hippocampal Stimulation Facilitates Memory in Patients With a History of Head Impact and/or Brain Injury
Published in Frontiers in human neuroscience (25-07-2022)“…Rationale: Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement of memory impaired by injury or disease. Many pre-clinical DBS paradigms…”
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Nonlinear modeling of neural population dynamics for hippocampal prostheses
Published in Neural networks (01-11-2009)“…Developing a neural prosthesis for the damaged hippocampus requires restoring the transformation of population neural activities performed by the hippocampal…”
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Neural activity in frontal cortical cell layers: evidence for columnar sensorimotor processing
Published in Journal of cognitive neuroscience (01-06-2011)“…The mammalian frontal cortex (FCx) is at the top of the brain's sensorimotor hierarchy and includes cells in the supragranular Layer 2/3, which integrate…”
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Prefrontal cortical microcircuits bind perception to executive control
Published in Scientific reports (29-07-2013)“…During the perception-to-action cycle, our cerebral cortex mediates the interactions between the environment and the perceptual-executive systems of the brain…”
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Corrigendum: Patterned hippocampal stimulation facilitates memory in patients with a history of head impact and/or brain injury
Published in Frontiers in human neuroscience (06-10-2022)Get full text
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Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall of stimulus features and categories
Published in Frontiers in computational neuroscience (08-02-2024)“…Here, we demonstrate the first successful use of static neural stimulation patterns for specific information content. These static patterns were derived by a…”
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Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3
Published in PLoS computational biology (01-07-2017)“…Much of the research on cannabinoids (CBs) has focused on their effects at the molecular and synaptic level. However, the effects of CBs on the dynamics of…”
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Nonlinear Dynamic Modeling of Spike Train Transformations for Hippocampal-Cortical Prostheses
Published in IEEE transactions on biomedical engineering (01-06-2007)“…One of the fundamental principles of cortical brain regions, including the hippocampus, is that information is represented in the ensemble firing of…”
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Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates
Published in PLoS biology (01-09-2005)“…The deleterious effects of prolonged sleep deprivation on behavior and cognition are a concern in modern society. Persons at risk for impaired performance and…”
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Differential but Complementary Mnemonic Functions of the Hippocampus and Subiculum
Published in Neuron (Cambridge, Mass.) (13-05-2004)“…In this study we describe how the hippocampus and subiculum act in concert to encode information in a spatial delayed-nonmatch-to-sample (DNMS) task. This…”
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Experience-Dependent Regulation of the Immediate-Early Gene Arc Differs across Brain Regions
Published in The Journal of neuroscience (23-07-2003)“…Previously, we demonstrated that initial acquisition of a lever-press task resulted in higher levels of activity-regulated cytoskeleton-associated protein…”
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Donor/recipient enhancement of memory in rat hippocampus
Published in Frontiers in systems neuroscience (01-01-2013)“…The critical role of the mammalian hippocampus in the formation, translation and retrieval of memory has been documented over many decades. There are many…”
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Closing the loop in primate prefrontal cortex: inter-laminar processing
Published in Frontiers in neural circuits (2012)“…Prefrontal cortical (PFC) activity in the primate brain emerging from minicolumnar microcircuits plays a critical role in cognitive processes dealing with…”
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Cannabinoids Reveal the Necessity of Hippocampal Neural Encoding for Short-Term Memory in Rats
Published in The Journal of neuroscience (01-12-2000)“…The memory-disruptive effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and the synthetic cannabinoid WIN 55,212-2 (WIN-2) were assessed in rats exposed…”
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