Search Results - "Deacon, T.W."

The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence by Deacon, T W, Pakzaban, P, Isacson, O

“…In order to determine whether the lateral ganglionic eminence (LGE) of the fetal telencephalon is the primary source of striatal precursors in striatal…”
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Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat by Isacson, O., Deacon, T.W.

“…The presence and specificity of axon guidance cues in the mature brain were examined by transplanting several types of xenogeneic neural cells from fetal pig…”
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A Novel Immunophilin Ligand: Distinct Branching Effects on Dopaminergic Neurons in Culture and Neurotrophic Actions after Oral Administration in an Animal Model of Parkinson's Disease by Costantini, L.C., Chaturvedi, P., Armistead, D.M., McCaffrey, P.G., Deacon, T.W., Isacson, O.

“…Protection or regeneration of the dopaminergic (DA) system would be of significant therapeutic value for Parkinson's disease. Immunophilin ligands, such as…”
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A novel mode of immunoprotection of neural xenotransplants: Masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system by Pakzaban, P., Deacon, T.W., Burns, L.H., Dinsmore, J., Isacson, O.

“…To determine the role of major histocompatibility complex (MHC) class I in immunological rejection of neural xenotransplants, F(ab′) 2 fragments of a…”
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Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease by Burns, L.H., Pakzaban, P., Deacon, T.W., Brownell, A.-L., Tatter, S.B., Jenkins, B.G., Isacson, O.

“…While dyskinetic movements have been reported in primates with unilateral excitotoxic lesions following stimulation by dopaminergic agonists, the presence and…”
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Cytoarchitectonic development, axon-glia relationships, and long distance axon growth of porcine striatal xenografts in rats by Deacon, T W, Pakzaban, P, Burns, L H, Dinsmore, J, Isacson, O

“…Porcine fetal lateral ganglionic eminence cells were transplanted into the quinolinic-acid-lesioned corpus striatum of immunosuppressed adult rats. The…”
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Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence by Pakzaban, P, Deacon, T W, Burns, L H, Isacson, O

“…Fetal striatal grafts are found to have a modular organization revealed by acetylcholinesterase (AChE) histochemistry. The AChE-rich zones represent the only…”
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Enhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum by Holm, K.H., Cicchetti, F., Bjorklund, L., Boonman, Z., Tandon, P., Costantini, L.C., Deacon, T.W., Huang, X., Chen, D.F., Isacson, O.

“…Embryonic neurons transplanted to the adult CNS extend axons only for a developmentally defined period. There are certain intercellular factors that control…”
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