Search Results - "Dea, M. A."

The kinetoplastid chemotherapy revisited: current drugs, recent advances and future perspectives by Castillo, E, Dea-Ayuela, M A, Bolás-Fernández, F, Rangel, M, González-Rosende, M E

“…Leishmaniasis, African sleeping sickness and Chagas disease, caused by the kinetoplastid parasites Leishmania spp, Trypanosoma brucei and Trypanosoma cruzi,…”
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In vivo distribution and therapeutic efficacy of a novel amphotericin B poly-aggregated formulation by Espada, R., Valdespina, S., Dea, M. A., Molero, G., Ballesteros, M. P., Bolás, F., Torrado, J. J.

“…Objectives The purpose of this investigation is the study of toxicity, in vivo distribution and therapeutic activity against candidiasis of poly-aggregated…”
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Treatment of Experimental Visceral Leishmaniasis with Amphotericin B in Stable Albumin Microspheres by SANCHEZ-BRUNETE, J. A, DEA, M. A, RAMA, S, BOLAS, F, ALUNDA, J. M, RAPOSO, R, MENDEZ, M. T, TORRADO-SANTIAGO, S, TORRADO, J. J

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Real-Time Reverse Transcription-PCR Quantification of Cytokine mRNA Expression in Golden Syrian Hamster Infected with Leishmania infantum and Treated with a New Amphotericin B Formulation by RAMA INIGUEZ, S, DEA-AYUELA, M. A, SANCHEZ-BRUNETE, J. A, TORRADO, J. J, ALUNDA, J. M, BOLAS-FERNANDEZ, F

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Local anaesthetic systemic toxicity by Christie, Linsey E., MBChB (Hons) BSc (Hons) MRCP FRCA, Picard, John, BA MA DEA BM BCh FRCA, Weinberg, Guy L., MD

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Influence of the vehicle on the properties and efficacy of microparticles containing amphotericin B by Sánchez-Brunete, J. A., Dea, M. A., Rama, S., Bolás, F., Alunda, J. M., Torrado-Santiago, S., Torrado, J. J.

“…New microparticles containing amphotericin B (AMB) have been developed and manufactured by spray drying. To this end albumin, polylactic-co-glycolic acids…”
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Amphotericin B Molecular Organization as an Essential Factor to Improve Activity/Toxicity Ratio in the Treatment of Visceral Leishmaniasis by Sánchez-Brunete, J.A., Dea, M.A., Rama, S., Bolás, F., Alunda, J.M., Torrado-Santiago, S., Torrado, J.J.

“…An in vivo study has been performed in order to determine the influence of amphotericin B (AMB) molecular organization on the toxicity and activity of this…”
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3D entropy and moments prediction of enzyme classes and experimental-theoretic study of peptide fingerprints in Leishmania parasites by Concu, R., Dea-Ayuela, M.A., Perez-Montoto, L.G., Prado-Prado, F.J., Uriarte, E., Bolás-Fernández, F., Podda, G., Pazos, A., Munteanu, C.R., Ubeira, F.M., González-Díaz, H.

“…The number of protein 3D structures without function annotation in Protein Data Bank (PDB) has been steadily increased. This fact has led in turn to an…”
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Setting New Immunobiological Parameters in the Hamster Model of Visceral Leishmaniasis for In Vivo Testing of Antileishmanial Compounds by Dea-Ayuela, M. A, Rama-Íñiguez, S, Alunda, J. M, Bolás-Fernandez, F

“…To establish suitable immunobiological parameters for in vivo testing of new antileishmanial compounds in the golden hamster model of visceral leishmaniasis,…”
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Anti‐leishmanial activity of a new formulation of amphotericin B by Dea‐Ayuela, M. A., Rama‐Íñiguez, S., Sánchez‐Brunete, J. A., Torrado, J. J., Alunda, J. M., Bolás‐Fernández, F.

“…Summary The effectiveness of albumin microspheres loaded with amphotericin B was tested in an in vivo model of visceral leishmaniasis using the golden hamster…”
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Identification of proteins interacting with HSP70 mRNAs in Leishmania braziliensis by Ramírez, C.A., Dea-Ayuela, M.A., Gutiérrez-Blázquez, M.D., Bolas-Fernández, F., Requena, J.M., Puerta, C.J.

“…HSP70 protein is involved in Leishmania differentiation, apoptosis, antimony-resistance and host-immune response. Therefore, this protein and the regulatory…”
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Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers by de Pablo, E., O'Connell, P., Fernández-García, R., Marchand, S., Chauzy, A., Tewes, F., Dea-Ayuela, M.A., Kumar, D., Bolás, F., Ballesteros, M.P., Torrado, J.J., Healy, A.M., Serrano, D.R.

“…[Display omitted] The incidence of fungal pulmonary infections is known to be on the increase, and yet there is an alarming gap in terms of marketed antifungal…”
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Heterogeneity and immunogenicity of the Trichinella TSL‐1 antigen gp53 by Romarís, F., Dea‐Ayuela, M. A., Bolás, F., Martínez‐Fernández, A. R., Sanmartín, M. L., Ubeira, F. M.

“…SUMMARY This study investigates the heterogeneity and immunogenicity of the Trichinella TSL‐1 antigen gp53. Western blotting analysis of several Trichinella…”
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Two-dimensional electrophoresis and mass spectrometry for the identification of species-specific Trichinella antigens by Dea-Ayuela, M.A., Bolás-Fernández, F.

“…A proteomic approach was utilized for fine antigenic characterization of the closely related Trichinella genotypes Trichinella britovi T3 and Trichinella T8…”
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HPLC assay for determination of amphotericin B in biological samples by Espada, R., Josa, J. M., Valdespina, S., Dea, M. A., Ballesteros, M. P., Alunda, J. M., Torrado, J. J.

“…A fast and selective HPLC method for assaying amphotericin B in biological samples was developed and validated. The chromatographic separation was achieved in…”
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Contrasting effects of Trichinella spiralis and Trichuris muris antigens on the infection by Leishmania infantum in BALB/c mice by Dea-Ayuela, M.A., Rama-Iñiguez, S., Bolas-Fernández, F.

“…The interaction of Trichinella spiralis and Trichuris muris derived antigens with the infection by Leishmania infantum was investigated in BALB/c mice…”
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Possible presence of common tyvelose-containing glycans in Trichinella L1 larvae and embryonated eggs of several nematodes by Dea-Ayuela, M A, Romarís, F, Ubeira, F M, Rama-Iñiguez, S, Martínez-Fernández, A R, Bolás, F

“…A monoclonal antibody (mAb US4) recognising an epitope containing tyvelose within the T. spiralis L-1 muscle larvae (TSL-1) antigens was tested in western-blot…”
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A comparison of antigenic peptides in muscle larvae of several Trichinella species by two-dimensional western-blot analysis with monoclonal antibodies by Dea-Ayuela, M A, Ubeira, F M, Pitarch, A, Gil, C, Martínez-Fernández, A R, Bolás, F

“…The antigens recognised by mAb US5 specific to 53 kDa glycoprotein (gp 53) in T. spiralis L-1 muscle larvae (TSL1) antigens, mAb US9 specific to gp 53 in TSL1…”
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Comparison of IgG3 responses to carbohydrates following mouse infection or immunization with six species of Trichinella by Dea-Ayuela, M A, Martinez-Fernandez, A R, Bolas-Fernandez, F

“…The IgG3 antibody responses to carbohydrate epitopes were compared in BALB/c mice infected or immunized with six species of Trichinella: T. spiralis (T1), T…”
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Generalized lattice graphs for 2D-visualization of biological information by González-Díaz, H., Pérez-Montoto, L.G., Duardo-Sanchez, A., Paniagua, E., Vázquez-Prieto, S., Vilas, R., Dea-Ayuela, M.A., Bolas-Fernández, F., Munteanu, C.R., Dorado, J., Costas, J., Ubeira, F.M.

“…Several graph representations have been introduced for different data in theoretical biology. For instance, complex networks based on Graph theory are used to…”
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