Search Results - "DeWolf Jr, Walter E."

Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of Staphylococcus aureus by FAN, Frank, KANG YAN, SEEFELD, Mark A, NEWLANDER, Kenneth A, JAKAS, Dalia R, HEAD, Martha S, PAYNE, David J, WALLIS, Nicola G, REED, Shannon, MOORE, Terrance D, RITTENHOUSE, Stephen F, DEWOLF, Walter E, JIANZHONG HUANG, MCDEVITT, Damien, MILLER, William H

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The kinetic model of the shikimate pathway as a tool to optimize enzyme assays for high-throughput screening by Noble, Michael, Sinha, Yugesh, Kolupaev, Aleksey, Demin, Oleg, Earnshaw, David, Tobin, Frank, West, Joshua, Martin, John D., Qiu, Chunyan, Liu, Wu-Schyong, DeWolf Jr, Walter E., Tew, David, Goryanin, Igor I.

“…Four‐enzyme section of the shikimate pathway (Aro B, D, E, and K) of Streptococcus pneumoniae has been studied. Kinetic properties of the individual enzymes…”
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Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents by PAYNE, David J, MILLER, William H, HEERDING, Dirk A, JANSON, Cheryl A, JAWORSKI, Deborah D, KELLER, Paul M, MANLEY, Peter J, MOORE, Terrance D, NEWLANDER, Kenneth A, PEARSON, Stewart, POLIZZI, Brian J, XIAYANG QIU, BERRY, Valerie, RITTENHOUSE, Stephen F, SLATER-RADOSTI, Courtney, SALYERS, Kevin L, SEEFELD, Mark A, SMYTH, Martin G, TAKATA, Dennis T, UZINSKAS, Irene N, VAIDYA, Kalindi, WALLIS, Nicola G, WINRAM, Scott B, BROSKY, John, YUAN, Catherine C. K, HUFFMAN, William F, BURGESS, Walter J, CHEN, Emile, DEWOLF, Walter E, FOSBERRY, Andrew P, GREENWOOD, Rebecca, HEAD, Martha S

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Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator by Hinklin, Ronald J., Baer, Brian R., Boyd, Steven A., Chicarelli, Mark D., Condroski, Kevin R., DeWolf, Walter E., Fischer, John, Frank, Michele, Hingorani, Gary P., Lee, Patrice A., Neitzel, Nickolas A., Pratt, Scott A., Singh, Ajay, Sullivan, Francis X., Turner, Timothy, Voegtli, Walter C., Wallace, Eli M., Williams, Lance, Aicher, Thomas D.

“…[Display omitted] Glucose flux through glucokinase (GK) controls insulin release from the pancreas in response to high levels of glucose. Flux through GK is…”
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Identification of a New Class of Glucokinase Activators through Structure-Based Design by Hinklin, Ronald J, Boyd, Steven A, Chicarelli, Mark J, Condroski, Kevin R, DeWolf, Walter E, Lee, Patrice A, Lee, Waiman, Singh, Ajay, Thomas, Laurie, Voegtli, Walter C, Williams, Lance, Aicher, Thomas D

“…Glucose flux through glucokinase (GK) controls insulin release from the pancreas in response to high glucose concentrations. Glucose flux through GK also…”
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Discovery of 2‑Pyridylureas as Glucokinase Activators by Hinklin, Ronald J, Aicher, Thomas D, Anderson, Deborah A, Baer, Brian R, Boyd, Steven A, Condroski, Kevin R, DeWolf, Walter E, Kraser, Christopher F, McVean, Maralee, Rhodes, Susan P, Sturgis, Hillary L, Voegtli, Walter C, Williams, Lance, Houze, Jonathan B

“…Glucokinase (GK) is the rate-limiting step for insulin release from the pancreas in response to high levels of glucose. Flux through GK also contributes to…”
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Characterization of a novel glucokinase activator in rat and mouse models by Lu, Min, Li, Pingping, Bandyopadhyay, Gautam, Lagakos, William, Dewolf, Jr, Walter E, Alford, Taylor, Chicarelli, Mark Joseph, Williams, Lance, Anderson, Deborah A, Baer, Brian R, McVean, Maralee, Conn, Marion, Véniant, Murielle M, Coward, Peter

“…Glucokinase (GK) is a hexokinase isozyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate. Glucokinase activators are being investigated as…”
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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties by Kohn, Todd J, Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E, Kraser, Christopher F, Hinklin, Ronald J, Boys, Mark L, Medina, Julio C, Houze, Jonathan, Dransfield, Paul, Coward, Peter

“…Two 1-(4-aryl-5-alkyl-pyridin-2-yl)-3-methylurea glucokinase activators were identified with robust in vivo efficacy. These two compounds possessed higher…”
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Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394 by Dransfield, Paul J, Pattaropong, Vatee, Lai, Sujen, Fu, Zice, Kohn, Todd J, Du, Xiaohui, Cheng, Alan, Xiong, Yumei, Komorowski, Renee, Jin, Lixia, Conn, Marion, Tien, Eric, DeWolf, Walter E, Hinklin, Ronald J, Aicher, Thomas D, Kraser, Christopher F, Boyd, Steven A, Voegtli, Walter C, Condroski, Kevin R, Veniant-Ellison, Murielle, Medina, Julio C, Houze, Jonathan, Coward, Peter

“…Glucokinase (GK) catalyzes the phosphorylation of glucose to glucose-6-phosphate. We present the structure–activity relationships leading to the discovery of…”
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Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK by Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, DeWolf, Walter E, Elkins, Patricia A, Head, Martha S, Jakas, Dalia R, Janson, Cheryl A, Keller, Paul M, Manley, Peter J, Moore, Terrance D, Payne, David J, Pearson, Stewart, Polizzi, Brian J, Qiu, Xiayang, Rittenhouse, Stephen F, Uzinskas, Irene N, Wallis, Nicola G, Huffman, William F

“…Bacterial enoyl-ACP reductase (FabI) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis and is an attractive target for the…”
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Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality by Lee, Dennis, Long, Scott A., Adams, Jerry L., Chan, George, Vaidya, Kalindi S., Francis, Terry A., Kikly, Kristine, Winkler, James D., Sung, Chiu-Mei, Debouck, Christine, Richardson, Susan, Levy, Mark A., DeWolf, Walter E., Keller, Paul M., Tomaszek, Thaddeus, Head, Martha S., Ryan, M.Dominic, Haltiwanger, R.Curtis, Liang, Po-Huang, Janson, Cheryl A., McDevitt, Patrick J., Johanson, Kyung, Concha, Nestor O., Chan, Winnie, Abdel-Meguid, Sherin S., Badger, Alison M., Lark, Michael W., Nadeau, Daniel P., Suva, Larry J., Gowen, Maxine, Nuttall, Mark E.

“…Caspases have been strongly implicated to play an essential role in apoptosis. A critical question regarding the role(s) of these proteases is whether…”
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Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK) by Marrakchi, Hedia, Dewolf, Jr, Walter E, Quinn, Chad, West, Joshua, Polizzi, Brian J, So, Chi Y, Holmes, David J, Reed, Shannon L, Heath, Richard J, Payne, David J, Rock, Charles O, Wallis, Nicola G

“…The enoyl-(acyl-carrier protein) (ACP) reductase catalyses the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems. An…”
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Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI) by Miller, William H, Seefeld, Mark A, Newlander, Kenneth A, Uzinskas, Irene N, Burgess, Walter J, Heerding, Dirk A, Yuan, Catherine C. K, Head, Martha S, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, Pearson, Stewart C, Berry, Valerie, DeWolf, Walter E, Keller, Paul M, Polizzi, Brian J, Qiu, Xiayang, Janson, Cheryl A, Huffman, William F

“…Bacterial enoyl-ACP reductase (FabI) catalyzes the final step in each cycle of bacterial fatty acid biosynthesis and is an attractive target for the…”
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Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro by Nuttall, M E, Nadeau, D P, Fisher, P W, Wang, F, Keller, P M, DeWolf, Jr, W E, Goldring, M B, Badger, A M, Lee, D, Levy, M A, Gowen, M, Lark, M W

“…Apoptosis was induced in a human chondrocyte cell line, T/C 28a4, by treatment with various stimuli, including camptothecin, tumor necrosis factor-alpha,…”
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Apoptosis in polycystic kidney disease: involvement of caspases by Ali, S M, Wong, V Y, Kikly, K, Fredrickson, T A, Keller, P M, DeWolf, Jr, W E, Lee, D, Brooks, D P

“…Polycystic kidney disease (PKD) is characterized by the development of large renal cysts and progressive loss of renal function. Although the cause of the…”
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Role of conserved histidines in catalytic activity and inhibitor binding of human recombinant phosphodiesterase 4A by Jacobitz, S, Ryan, M D, McLaughlin, M M, Livi, G P, DeWolf, Jr, W E, Torphy, T J

“…To identify critical amino acids within the central conserved region of recombinant human cAMP-specific phosphodiesterase 4 subtype A (rhPDE4A), we engineered…”
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Endothelin-Converting Enzyme: Substrate Specificity and Inhibition by Novel Analogs of Phosphoramidon by Keller, Paul M., Lee, Chao-Pin, Fenwick, Ashley E., Atkinson, Steven T., Elliott, John D., DeWolf, Jr, Walter E.

“…Endothelin converting enzyme was partially purified by detergent extraction and ion exchange chromatography from porcine aortic endothelial cells. This…”
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TL1, a Novel Tumor Necrosis Factor-like Cytokine, Induces Apoptosis in Endothelial Cells by Yue, Tian-Li, Ni, Jian, Romanic, Anne M., Gu, Juan-Li, Keller, Paul, Wang, Chuanlin, Kumar, Sanjay, Yu, Guo-liang, Hart, Timothy K., Wang, Xinkang, Xia, Zhengui, DeWolf, Walter E., Feuerstein, Giora Z.

“…TL1 is a recently discovered novel member of the tumor necrosis factor (TNF) cytokine family. TL1 is abundantly expressed in endothelial cells, but its…”
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