Search Results - "DeWitt, S."

A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility by Cusanovich, Darren A., Hill, Andrew J., Aghamirzaie, Delasa, Daza, Riza M., Pliner, Hannah A., Berletch, Joel B., Filippova, Galina N., Huang, Xingfan, Christiansen, Lena, DeWitt, William S., Lee, Choli, Regalado, Samuel G., Read, David F., Steemers, Frank J., Disteche, Christine M., Trapnell, Cole, Shendure, Jay

“…We applied a combinatorial indexing assay, sci-ATAC-seq, to profile genome-wide chromatin accessibility in ∼100,000 single cells from 13 adult mouse tissues…”
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A Public Database of Memory and Naive B-Cell Receptor Sequences by DeWitt, William S, Lindau, Paul, Snyder, Thomas M, Sherwood, Anna M, Vignali, Marissa, Carlson, Christopher S, Greenberg, Philip D, Duerkopp, Natalie, Emerson, Ryan O, Robins, Harlan S

“…The vast diversity of B-cell receptors (BCR) and secreted antibodies enables the recognition of, and response to, a wide range of epitopes, but this diversity…”
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Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity by DeWitt, 3rd, William S, Smith, Anajane, Schoch, Gary, Hansen, John A, Matsen, 4th, Frederick A, Bradley, Philip

“…The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic formation of immunological memory. Statistical analysis of repertoire…”
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Traumatic brain injury: a disease process, not an event by Masel, Brent E, DeWitt, Douglas S

“…Traumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of…”
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Deep generative models for T cell receptor protein sequences by Davidsen, Kristian, Olson, Branden J, DeWitt, 3rd, William S, Feng, Jean, Harkins, Elias, Bradley, Philip, Matsen, 4th, Frederick A

“…Probabilistic models of adaptive immune repertoire sequence distributions can be used to infer the expansion of immune cells in response to stimulus,…”
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Phenotypic Manifestations of Arrhythmogenic Cardiomyopathy in Children and Adolescents by DeWitt, Elizabeth S., Chandler, Stephanie F., Hylind, Robyn J., Beausejour Ladouceur, Virginie, Blume, Elizabeth D., VanderPluym, Christina, Powell, Andrew J., Fynn-Thompson, Francis, Roberts, Amy E., Sanders, Stephen P., Bezzerides, Vassilios, Lakdawala, Neal K., MacRae, Calum A., Abrams, Dominic J.

“…Arrhythmogenic cardiomyopathy (ACM) is a variably penetrant disease increasingly identified in young patients. This study sought to describe the diverse…”
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Traumatic brain injury induces long-lasting changes in immune and regenerative signaling by Boone, Deborah R, Weisz, Harris A, Willey, Hannah E, Torres, Karen E O, Falduto, Michael T, Sinha, Mala, Spratt, Heidi, Bolding, Ian J, Johnson, Kathea M, Parsley, Margaret A, DeWitt, Douglas S, Prough, Donald S, Hellmich, Helen L

“…There are no existing treatments for the long-term degenerative effects of traumatic brain injury (TBI). This is due, in part, to our limited understanding of…”
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Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice by Gerson, Julia, Castillo-Carranza, Diana L, Sengupta, Urmi, Bodani, Riddhi, Prough, Donald S, DeWitt, Douglas S, Hawkins, Bridget E, Kayed, Rakez

“…Tau aggregation is a pathological feature of numerous neurodegenerative disorders and has also been shown to occur under certain conditions of traumatic brain…”
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Coronary artery compression from epicardial leads: More common than we think by Mah, Douglas Y., Prakash, Ashwin, Porras, Diego, Fynn-Thompson, Francis, DeWitt, Elizabeth S., Banka, Puja

“…A child with an epicardial pacemaker presented with sudden death at our institution, secondary to coronary artery compression. This case prompted enhanced…”
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Effects of Mild Blast Traumatic Brain Injury on Cerebral Vascular, Histopathological, and Behavioral Outcomes in Rats by Rodriguez, Uylissa A, Zeng, Yaping, Deyo, Donald, Parsley, Margaret A, Hawkins, Bridget E, Prough, Donald S, DeWitt, Douglas S

“…To determine the effects of mild blast-induced traumatic brain injury (bTBI), several groups of rats were subjected to blast injury or sham injury in a…”
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Simulations of Anodic Nanopore Growth Using the Smoothed Boundary and Level Set Methods by DeWitt, S, Thornton, K

“…Self-ordered nanostructured films can be fabricated through an electrochemical oxidation process called anodization. These films, with features on the order of…”
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Impact & Blast Traumatic Brain Injury: Implications for Therapy by Yamamoto, Satoshi, DeWitt, Douglas S, Prough, Donald S

“…Traumatic brain injury (TBI) is one of the most frequent causes of combat casualties in Operations Iraqi Freedom (OIF), Enduring Freedom (OEF), and New Dawn…”
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MicroRNA sequencing of rat hippocampus and human biofluids identifies acute, chronic, focal and diffuse traumatic brain injuries by Weisz, Harris A., Kennedy, Deborah, Widen, Steven, Spratt, Heidi, Sell, Stacy L., Bailey, Christine, Sheffield-Moore, Melinda, DeWitt, Douglas S., Prough, Donald S., Levin, Harvey, Robertson, Claudia, Hellmich, Helen L.

“…High-throughput sequencing technologies could improve diagnosis and classification of TBI subgroups. Because recent studies showed that circulating microRNAs…”
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Retroflexed catheter course reduces the risk of right free wall accessory pathway recurrence by Przybylski, Robert, DeWitt, Elizabeth S, Meziab, Omar, Gauvreau, Kimberlee, Dionne, Audrey, O'Leary, Edward T, Alexander, Mark E, Walsh, Edward P, Mah, Douglas Y

“…Accessory atrioventricular pathways (APs) may mediate atrioventricular reciprocating tachycardia and, in some cases, have the potential to conduct atrial…”
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A Diverse Lipid Antigen-Specific TCR Repertoire Is Clonally Expanded during Active Tuberculosis by DeWitt, William S, Yu, Krystle K Q, Wilburn, Damien B, Sherwood, Anna, Vignali, Marissa, Day, Cheryl L, Scriba, Thomas J, Robins, Harlan S, Swanson, Willie J, Emerson, Ryan O, Bradley, Philip H, Seshadri, Chetan

“…Human T cells that recognize lipid Ags presented by highly conserved CD1 proteins often express semi-invariant TCRs, but the true diversity of lipid…”
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Using Genotype Abundance to Improve Phylogenetic Inference by DeWitt, 3rd, William S, Mesin, Luka, Victora, Gabriel D, Minin, Vladimir N, Matsen, 4th, Frederick A

“…Modern biological techniques enable very dense genetic sampling of unfolding evolutionary histories, and thus frequently sample some genotypes multiple times…”
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Human Neural Stem Cell Transplantation-Mediated Alteration of Microglial/Macrophage Phenotypes after Traumatic Brain Injury by Gao, Junling, Grill, Raymond J, Dunn, Tiffany J, Bedi, Supinder, Labastida, Javier Allende, Hetz, Robert A, Xue, Hasen, Thonhoff, Jason R, DeWitt, Douglas S, Prough, Donald S, Cox, Jr, Charles S, Wu, Ping

“…Neural stem cells (NSCs) promote recovery from brain trauma, but neuronal replacement is unlikely the sole underlying mechanism. We hypothesize that grafted…”
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Traumatic brain injury-induced dysregulation of the circadian clock by Boone, Deborah R, Sell, Stacy L, Micci, Maria-Adelaide, Crookshanks, Jeanna M, Parsley, Margaret, Uchida, Tatsuo, Prough, Donald S, DeWitt, Douglas S, Hellmich, Helen L

“…Circadian rhythm disturbances are frequently reported in patients recovering from traumatic brain injury (TBI). Since circadian clock output is mediated by…”
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Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury by Boone, Deborah R, Leek, Jeanna M, Falduto, Michael T, Torres, Karen E O, Sell, Stacy L, Parsley, Margaret A, Cowart, Jeremy C, Uchida, Tatsuo, Micci, Maria-Adelaide, DeWitt, Douglas S, Prough, Donald S, Hellmich, Helen L

“…Virally mediated RNA interference (RNAi) to knock down injury-induced genes could improve functional outcome after traumatic brain injury (TBI); however,…”
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Differentiation of fasciculoventricular fibers from anteroseptal accessory pathways using the surface electrocardiogram by O’Leary, Edward T., Dewitt, Elizabeth S., Mah, Douglas Y., Gauvreau, Kimberlee, Walsh, Edward P., Bezzerides, Vassilios J.

“…Fasciculoventricular fibers (FVFs) are responsible for 1%–5% of cases of asymptomatic preexcitation on the surface electrocardiogram (ECG). Unlike ventricular…”
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