Search Results - "DeWald, Horace A"

Synthesis and dopamine agonist properties of (+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol and its enantiomers by DeWald, Horace A, Heffner, Thomas G, Jaen, Juan C, Lustgarten, David M, McPhail, Andrew T, Meltzer, Leonard T, Pugsley, Thomas A, Wise, Lawrence D

“…The dopamine agonist profile of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was…”
Get full text

Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines by DeWald, Horace A, Beeson, Nicholas W, Hershenson, Fred M, Wise, Lawrence D, Downs, David A, Heffner, Thomas G, Coughenour, Linda L, Pugsley, Thomas A

“…The synthesis of a series of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines is reported along with the effects of these compounds in preclinical tests for…”
Get full text

6- and 8-Hydroxy-3,4-dihydro-3-(dipropylamino)-2H-1-benzopyrans. Dopamine agonists with autoreceptor selectivity by Wise, Lawrence D, DeWald, Horace A, Hawkins, Elma S, Reynolds, Donna M, Heffner, Thomas G, Meltzer, Leonard T, Pugsley, Thomas A

“…The dopamine agonist profiles of 3,4-dihydro-3-(3-dipropylamino)-2H-1-benzopyran-6- and -8-ol (4 and 5, respectively) were examined. Both 4 and 5 exhibited…”
Get full text

Pyrazolodiazepines. 2. 4-Aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1H)-ones as antianxiety and anticonvulsant agents by DeWald, Horace A, Lobbestael, Sandra, Butler, Donald E

“…A series of 4-aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e] [1,4]diazepin-7(1H)-ones was synthesized and screened for psychotropic activity. In animals, a number…”
Get full text

General methods for the substitution of 5- chloropyrazoles. Synthesis of 1,3-dialkyl-5-chloropyrazol-4-yl aryl ketones and new 1,3-dialkyl-2-pyrazolin-5-ones by Butler, Donald Eugene, DeWald, Horace A

Get full text

(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones. A series of novel potential antipsychotic agents by Wise, Lawrence D, Butler, Donald E, DeWald, Horace A, Lustgarten, David, Coughenour, Linda L, Downs, David A, Heffner, Thomas G, Pugsley, Thomas A

“…(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanone (1) was found to have an antipsychotic-like profile in behavioral tests predictive of…”
Get full text

(1,3-Dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones. A series of novel central nervous system depressants by Butler, Donald E, Wise, Lawrence D, DeWald, Horace A

“…A series of novel (1,3-dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones was synthesized. Pharmacological evaluation of these compounds demonstrated central…”
Get full text

N-Dealkylation of pyrazoles using pyridine hydrochloride by Butler, Donald E, DeWald, Horace A

Get full text

Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8-triazaspiro[4.5]decan-4-ones as potential antipsychotic agents by Wise, Lawrence D, Pattison, Ian C, Butler, Donald E, DeWald, Horace A, Lewis, Edward P, Lobbestael, Sandra J, Tecle, Haile, Coughenour, Linda L, Downs, David A, Poschel, B. P. H

“…8-[3-[Bis(4-fluorophenyl)amino]propyl]-1-phenyl-1,3,8- triazaspiro[4.5]decan-4-one (3) and related compounds have been shown to have antipsychotic profiles in…”
Get full text

1,3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents by Wise, Lawrence D, Butler, Donald E, DeWald, Horace A, Lustgarten, David M, Pattison, Ian C, Schweiss, Dieter N, Coughenour, Linda L, Downs, David A, Heffner, Thomas G, Pugsley, Thomas A

“…2-(Diethylamino)-N-[4-(2-fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl] acetamide (1) was recently found to have an antipsychotic-like profile in behavioral…”
Get full text

1-[3-(Diarylamino)propyl]piperidines and Related Compounds, Potential Antipsychotic Agents with Low Cataleptogenic Profiles by Wise, Lawrence D, Pattison, Ian C, Butler, Donald E, DeWald, Horace A, Lewis, Edward P, Lobbestael, Sandra J, Nordin, Ivan C, Poschel, B. P. H, Coughenour, Linda L

“…On the basis of a structural model of the postsynaptic dopaminergic antagonist pharmacophore, a series of 1-[3-(diarylamino)propyl]piperidines and related…”
Get full text

Diazoacetic Esters of Hydroxyamino Acids1 by DeWald, Horace A, Behn, D. Craig, Moore, Alexander M

Get full text

6-Diazo-5-oxo-L-norleucine, a New Tumor-inhibitory Substance.1a Preparation of L-, D- and DL-Forms1b by DeWald, Horace A, Moore, Alexander M

Get full text

Some New Esters of Serine with Various Acids1 by DeWald, Horace A, Behn, D. Craig, Morgan, Marcus S, Renfrew, Alice G, Moore, Alexander M

Get full text

THE ADDITION OF GRIGNARD REAGENTS TO THE DIBIPHENYLENEPOLYENES by FUSON, REYNOLD C, DeWALD, HORACE A, GAERTNER, RUSSELL

Get full text

A New Class of Orally Effective Antifertility Agents with Hypocholesteraemic Activity by DEWALD, HORACE A, BIRD, ORSON D, RODNEY, GERTRUDE, KAUMP, DONALD H, BLACK, MARTIN L

Get full text

2-(2-Pyridyl)-1,2-diarylalkanols as Hypocholesteremic Agents by Burckhalter, J. H, Dixon, William D, Black, Martin L, Westland, Roger D, Werbel, Leslie M, DeWald, Horace A, Dice, John R, Rodney, Gertrude, Kaump, Donald H

Get full text

The synthesis of 4-(o-fluorophenyl)-6,8-dihydro-3,8-dimethyl-pyrazolo[3,4-e][1,4]diazepin-7(IH)one, a metabolite of zolazepam by Dewald, Horace A.

“…A metabolite of Zolazepam was prepared by a selective N‐demethylation of a dihydro derivative of Zolazepam using pyridine hydrochloride…”
Get full text

6-Diazo-5-oxo-L-norleucine, a New Tumor-inhibitory Substance. 1a Preparation of L-, D- and DL-Forms 1b by DeWald, Horace A., Moore, Alexander M.

Get full text

Diazoacetic Esters of Hydroxyamino Acids 1 by DeWald, Horace A., Behn, D. Craig, Moore, Alexander M.

Get full text