Search Results - "DeVoss, Jason J."

Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells by Gardner, James M, DeVoss, Jason J, Friedman, Rachel S, Wong, David J, Tan, Ying X, Zhou, Xuyu, Johannes, Kellsey P, Su, Maureen A, Chang, Howard Y, Krummel, Matthew F, Anderson, Mark S

“…The prevention of autoimmunity requires the elimination of self-reactive T cells during their development and maturation. The expression of diverse…”
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Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection by Taniguchi, Ruth T, DeVoss, Jason J, Moon, James J, Sidney, John, Sette, Alessandro, Jenkins, Marc K, Anderson, Mark S

“…The autoimmune regulator (Aire) plays a critical role in central tolerance by promoting the display of tissue-specific antigens in the thymus. To study the…”
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Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire by Su, Maureen A, Giang, Karen, Zumer, Kristina, Jiang, Huimin, Oven, Irena, Rinn, John L, Devoss, Jason J, Johannes, Kellsey P A, Lu, Wen, Gardner, James, Chang, Angela, Bubulya, Paula, Chang, Howard Y, Peterlin, B Matija, Anderson, Mark S

“…Homozygous loss-of-function mutations in AIRE cause autoimmune polyglandular syndrome type 1 (APS 1), which manifests in a classic triad of hypoparathyroidism,…”
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Effector Mechanisms of the Autoimmune Syndrome in the Murine Model of Autoimmune Polyglandular Syndrome Type 1 by DeVoss, Jason J, Shum, Anthony K, Johannes, Kellsey P. A, Lu, Wen, Krawisz, Anna K, Wang, Peter, Yang, Ting, LeClair, Norbert P, Austin, Cecilia, Strauss, Erich C, Anderson, Mark S

“…Mutations in the Aire gene result in a clinical phenomenon known as Autoimmune Polyglandular Syndrome (APS) Type I, which classically manifests as a triad of…”
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Multiple Elements of the Allergic Arm of the Immune Response Modulate Autoimmune Demyelination by Pedotti, Rosetta, DeVoss, Jason J., Youssef, Sawsan, Mitchell, Dennis, Wedemeyer, Jochen, Madanat, Rami, Garren, Hideki, Fontoura, Paulo, Tsai, Mindy, Galli, Stephen J., Sobel, Raymond A., Steinman, Lawrence

“…Analysis of mRNA from multiple sclerosis lesions revealed increased amounts of transcripts for several genes encoding molecules traditionally associated with…”
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A Suppressive Oligodeoxynucleotide Enhances the Efficacy of Myelin Cocktail/IL-4-Tolerizing DNA Vaccination and Treats Autoimmune Disease by Ho, Peggy P, Fontoura, Paulo, Platten, Michael, Sobel, Raymond A, DeVoss, Jason J, Lee, Lowen Y, Kidd, Brian A, Tomooka, Beren H, Capers, Julien, Agrawal, Ashish, Gupta, Rohit, Zernik, Jonathan, Yee, Michael K, Lee, Byung J, Garren, Hideki, Robinson, William H, Steinman, Lawrence

“…Targeting pathogenic T cells with Ag-specific tolerizing DNA vaccines encoding autoantigens is a powerful and feasible therapeutic strategy for Th1-mediated…”
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Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy by Su, Maureen A, Davini, Dan, Cheng, Philip, Giang, Karen, Fan, Una, DeVoss, Jason J, Johannes, Kellsey P A, Taylor, Lorelei, Shum, Anthony K, Valenzise, Mariella, Meloni, Antonella, Bour-Jordan, Helene, Anderson, Mark S

“…Chronic inflammatory demyelinating polyneuropathy is a debilitating autoimmune disease characterized by peripheral nerve demyelination and dysfunction. How the…”
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An Autoimmune Response to Odorant Binding Protein 1a Is Associated with Dry Eye in the Aire-Deficient Mouse by DeVoss, Jason J, LeClair, Norbert P, Hou, Yafei, Grewal, Navdeep K, Johannes, Kellsey P, Lu, Wen, Yang, Ting, Meagher, Craig, Fong, Lawrence, Strauss, Erich C, Anderson, Mark S

“…Sjögren's Syndrome (SS) is a human autoimmune disease characterized by immune-mediated destruction of the lacrimal and salivary glands. In this study, we show…”
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A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy by Louvet, Cédric, Kabre, Beniwende G, Davini, Dan W, Martinier, Nicolas, Su, Maureen A, DeVoss, Jason J, Rosenthal, Wendy L, Anderson, Mark S, Bour-Jordan, Hélène, Bluestone, Jeffrey A

“…Autoimmune-prone nonobese diabetic mice deficient for B7-2 spontaneously develop an autoimmune peripheral neuropathy mediated by inflammatory CD4(+) T cells…”
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Lessons on immune tolerance from the monogenic disease APS1 by DeVoss, Jason J, Anderson, Mark S

“…Autoimmunity is a complex disease process that results from a breakdown in the ability of the immune system to discriminate self from non-self. One approach to…”
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Analysis of neuronal gene expression with laser capture microdissection by Vincent, Valerie A.M., DeVoss, Jason J., Ryan, Heather S., Murphy Jr, Greer M.

“…The brain is a heterogeneous tissue in which the numbers of neurons, glia, and other cell types vary among anatomic regions. Gene expression studies performed…”
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Comparison of cesium and X-ray irradiation for generation of bone marrow chimeras by Eng, Jason Samuel, Orf, Jessica, Perez, Kristy, Sawant, Deepali, DeVoss, Jason J

“…Abstract Bone marrow chimeras are mice which have been irradiated with ionizing radiation, thus killing their bone marrow and all bone marrow derived cells,…”
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Immunomodulation of Experimental Autoimmune Encephalomyelitis with Ordered Peptides Based on MHC-TCR Binding Motifs by Ruiz, Pedro J, DeVoss, Jason J, Nguyen, Louis-Vu T, Fontoura, Paulo P, Hirschberg, David L, Mitchell, Dennis J, Garcia, K. Christopher, Steinman, Lawrence

“…T cell-mediated destruction of the myelin sheath causes inflammatory damage of the CNS in multiple sclerosis (MS). The major T and B cell responses in MS…”
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Defective Aire-Dependent Central Tolerance to P0 Is Linked to Autoimmune Peripheral Neuropathy by Su, Maureen A., Davini, Dan, Cheng, Philip, Giang, Karen, Fan, Una, DeVoss, Jason J., Johannes, Kellsey P.A., Taylor, Lorelei, Shum, Anthony K., Valenzise, Mariella, Meloni, Antonella, Bour-Jordan, Helene, Anderson, Mark S.

“…Chronic Inflammatory Demyelinating Polyneuropathy is a debilitating autoimmune disease characterized by peripheral nerve demyelination and dysfunction. How the…”
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An autoimmune response to OBP1a is associated with dry eye in the Aire-deficient mouse by DeVoss, Jason J, LeClair, Norbert, Hou, Yafei, Grewal, Navdeep, Johannes, Kellsey, Lu, Wen, Yang, Ting, Meagher, Craig, Fong, Lawrence, Strauss, Erich C., Anderson, Mark S.

“…Sjögren’s Syndrome is a human autoimmune disease characterized by immune-mediated destruction of the lacrimal and salivary glands. Here, we show that the Aire…”
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A novel myelin P0aspecific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy by Louvet, CACOdric, Kabre, Beniwende G, Davini, Dan W, Martinier, Nicolas, Su, Maureen A, DeVoss, Jason J, Rosenthal, Wendy L, Anderson, Mark S, Bour-Jordan, HACOlA"ne, Bluestone, Jeffrey A

“…Autoimmune-prone nonobese diabetic mice deficient for B7-2 spontaneously develop an autoimmune peripheral neuropathy mediated by inflammatory CD4 super(+) T…”
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