Search Results - "DeVoss, J."

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury by Newton, K, Dugger, D L, Maltzman, A, Greve, J M, Hedehus, M, Martin-McNulty, B, Carano, R A D, Cao, T C, van Bruggen, N, Bernstein, L, Lee, W P, Wu, X, DeVoss, J, Zhang, J, Jeet, S, Peng, I, McKenzie, B S, Roose-Girma, M, Caplazi, P, Diehl, L, Webster, J D, Vucic, D

“…Necroptosis is a caspase-independent form of cell death that is triggered by activation of the receptor interacting serine/threonine kinase 3 (RIPK3) and…”
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Mouse Models of Rheumatoid Arthritis by Caplazi, P., Baca, M., Barck, K., Carano, R. A. D., DeVoss, J., Lee, W. P., Bolon, B., Diehl, L.

“…Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder characterized by synovitis that leads to cartilage and bone erosion by invading…”
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Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells by Gardner, James M, DeVoss, Jason J, Friedman, Rachel S, Wong, David J, Tan, Ying X, Zhou, Xuyu, Johannes, Kellsey P, Su, Maureen A, Chang, Howard Y, Krummel, Matthew F, Anderson, Mark S

“…The prevention of autoimmunity requires the elimination of self-reactive T cells during their development and maturation. The expression of diverse…”
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Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection by Taniguchi, Ruth T, DeVoss, Jason J, Moon, James J, Sidney, John, Sette, Alessandro, Jenkins, Marc K, Anderson, Mark S

“…The autoimmune regulator (Aire) plays a critical role in central tolerance by promoting the display of tissue-specific antigens in the thymus. To study the…”
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RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury by Newton, K, Dugger, D L, Maltzman, A, Greve, J M, Hedehus, M, Martin-McNulty, B, Carano, R A D, Cao, T C, van Bruggen, N, Bernstein, L, Lee, W P, Wu, X, DeVoss, J, Zhang, J, Jeet, S, Peng, I, McKenzie, B S, Roose-Girma, M, Caplazi, P, Diehl, L, Webster, J D, Vucic, D

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Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire by Su, Maureen A, Giang, Karen, Zumer, Kristina, Jiang, Huimin, Oven, Irena, Rinn, John L, Devoss, Jason J, Johannes, Kellsey P A, Lu, Wen, Gardner, James, Chang, Angela, Bubulya, Paula, Chang, Howard Y, Peterlin, B Matija, Anderson, Mark S

“…Homozygous loss-of-function mutations in AIRE cause autoimmune polyglandular syndrome type 1 (APS 1), which manifests in a classic triad of hypoparathyroidism,…”
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Multiple Elements of the Allergic Arm of the Immune Response Modulate Autoimmune Demyelination by Pedotti, Rosetta, DeVoss, Jason J., Youssef, Sawsan, Mitchell, Dennis, Wedemeyer, Jochen, Madanat, Rami, Garren, Hideki, Fontoura, Paulo, Tsai, Mindy, Galli, Stephen J., Sobel, Raymond A., Steinman, Lawrence

“…Analysis of mRNA from multiple sclerosis lesions revealed increased amounts of transcripts for several genes encoding molecules traditionally associated with…”
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Effector Mechanisms of the Autoimmune Syndrome in the Murine Model of Autoimmune Polyglandular Syndrome Type 1 by DeVoss, Jason J, Shum, Anthony K, Johannes, Kellsey P. A, Lu, Wen, Krawisz, Anna K, Wang, Peter, Yang, Ting, LeClair, Norbert P, Austin, Cecilia, Strauss, Erich C, Anderson, Mark S

“…Mutations in the Aire gene result in a clinical phenomenon known as Autoimmune Polyglandular Syndrome (APS) Type I, which classically manifests as a triad of…”
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Image Analysis-Based Approaches for Scoring Mouse Models of Colitis by Rogers, R., Eastham-Anderson, J., DeVoss, J., Lesch, J., Yan, D., Xu, M., Solon, M., Hotzel, K., Diehl, L., Webster, J. D.

“…Mouse models of inflammatory bowel disease are critical for basic and translational research that is advancing the understanding and treatment of this disease…”
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Formation of Indigo by Recombinant Mammalian Cytochrome P450 by Gillam, Elizabeth M.J., Aguinaldo, Anna Marie A., Notley, Lisa M., Kim, Donghak, Mundkowski, Ralf G., Volkov, Alexander A., Arnold, Frances H., Souček, Pavel, DeVoss, James J., Guengerich, F.Peter

“…The development of bicistronic systems for coexpression of recombinant human cytochrome P450 enzymes (P450s) with their redox partner, NADPH-cytochrome P450…”
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A Suppressive Oligodeoxynucleotide Enhances the Efficacy of Myelin Cocktail/IL-4-Tolerizing DNA Vaccination and Treats Autoimmune Disease by Ho, Peggy P, Fontoura, Paulo, Platten, Michael, Sobel, Raymond A, DeVoss, Jason J, Lee, Lowen Y, Kidd, Brian A, Tomooka, Beren H, Capers, Julien, Agrawal, Ashish, Gupta, Rohit, Zernik, Jonathan, Yee, Michael K, Lee, Byung J, Garren, Hideki, Robinson, William H, Steinman, Lawrence

“…Targeting pathogenic T cells with Ag-specific tolerizing DNA vaccines encoding autoantigens is a powerful and feasible therapeutic strategy for Th1-mediated…”
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Extending the diversity of cytochrome P450 enzymes by DNA family shuffling by Rosic, Nedeljka N., Huang, Weiliang, Johnston, Wayne A., DeVoss, James J., Gillam, Elizabeth M.J.

“…The cytochrome P450 enzymes involved in xenobiotic metabolism are an excellent starting point for the directed evolution of novel biocatalysts due to their…”
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Cytochrome P450-Mediated Metabolism of Haloperidol and Reduced Haloperidol to Pyridinium Metabolites by Avent, Kathryn M, DeVoss, J. J, Gillam, Elizabeth M. J

“…Haloperidol (HP) has been reported to undergo cytochrome P450 (P450)-mediated metabolism to potentially neurotoxic pyridinium metabolites; however, the…”
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Analysis of neuronal gene expression with laser capture microdissection by Vincent, Valerie A.M., DeVoss, Jason J., Ryan, Heather S., Murphy Jr, Greer M.

“…The brain is a heterogeneous tissue in which the numbers of neurons, glia, and other cell types vary among anatomic regions. Gene expression studies performed…”
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Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere by Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul, Williams, Craig M.

“…Pharmaceutical and agrochemical discovery programs are under considerable pressure to meet increasing global demand and thus require constant innovation…”
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Sulfur tolerant PdAu and PdAuPt alloy hydrogen separation membranes by Coulter, Kent E., Way, J. Douglas, Gade, Sabina K., Chaudhari, Saurabh, Alptekin, Gökhan O., DeVoss, Sarah J., Paglieri, Stephen N., Pledger, Bill

“…► PdAu alloy exhibited permeabilities higher than pure Pd and the addition of Pt lowered the permeability in pure gas to slightly below pure Pd. ► A thick…”
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Palladium–gold membranes in mixed gas streams with hydrogen sulfide: Effect of alloy content and fabrication technique by Gade, Sabina K., DeVoss, Sarah J., Coulter, Kent E., Paglieri, Stephen N., Alptekin, Gökhan O., Way, J. Douglas

“…▶ Pd–Au membranes were tested in synthetic WGS mixtures with up to 50 ppm H 2S. ▶ Higher gold content increases sulfur and carbon tolerance. ▶ Cold worked…”
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ASSESSMENT OF ARGININE 97 AND LYSINE 72 AS DETERMINANTS OF SUBSTRATE SPECIFICITY IN CYTOCHROME P450 2C9 (CYP2C9) by DAVIES, Carwyn, WITHAM, Katey, SCOTT, Justin R, PEARSON, Andrew, DEVOSS, James J, GRAHAM, Sandra E, GILLAM, Elizabeth M. J

“…CYP2C9 is distinguished by a preference for substrates bearing a negative charge at physiological pH. Previous studies have suggested that CYP2C9 residues R97…”
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Immunomodulation of Experimental Autoimmune Encephalomyelitis with Ordered Peptides Based on MHC-TCR Binding Motifs by Ruiz, Pedro J, DeVoss, Jason J, Nguyen, Louis-Vu T, Fontoura, Paulo P, Hirschberg, David L, Mitchell, Dennis J, Garcia, K. Christopher, Steinman, Lawrence

“…T cell-mediated destruction of the myelin sheath causes inflammatory damage of the CNS in multiple sclerosis (MS). The major T and B cell responses in MS…”
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Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy by Su, Maureen A, Davini, Dan, Cheng, Philip, Giang, Karen, Fan, Una, DeVoss, Jason J, Johannes, Kellsey P A, Taylor, Lorelei, Shum, Anthony K, Valenzise, Mariella, Meloni, Antonella, Bour-Jordan, Helene, Anderson, Mark S

“…Chronic inflammatory demyelinating polyneuropathy is a debilitating autoimmune disease characterized by peripheral nerve demyelination and dysfunction. How the…”
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