Search Results - "DeVos, Sarah"

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies by Sanders, David W., Kaufman, Sarah K., DeVos, Sarah L., Sharma, Apurwa M., Mirbaha, Hilda, Li, Aimin, Barker, Scarlett J., Foley, Alex C., Thorpe, Julian R., Serpell, Louise C., Miller, Timothy M., Grinberg, Lea T., Seeley, William W., Diamond, Marc I.

“…Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique…”
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Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model by Schoch, Kathleen M., DeVos, Sarah L., Miller, Rebecca L., Chun, Seung J., Norrbom, Michaela, Wozniak, David F., Dawson, Hana N., Bennett, C. Frank, Rigo, Frank, Miller, Timothy M.

“…Pathological evidence for selective four-repeat (4R) tau deposition in certain dementias and exon 10-positioned MAPT mutations together suggest a 4R-specific…”
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Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia by Simon, Matthew J., Logan, Todd, DeVos, Sarah L., Di Paolo, Gilbert

“…Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN), were identified in patients with frontotemporal lobar degeneration (FTLD)…”
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The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease by Hopp, Sarah C, Lin, Yang, Oakley, Derek, Roe, Allyson D, DeVos, Sarah L, Hanlon, David, Hyman, Bradley T

“…Misfolding of microtubule-associated protein tau (MAPT) within neurons into neurofibrillary tangles is an important pathological feature of Alzheimer's disease…”
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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds by Holmes, Brandon B, DeVos, Sarah L, Kfoury, Najla, Li, Mei, Jacks, Rachel, Yanamandra, Kiran, Ouidja, Mohand O, Brodsky, Frances M, Marasa, Jayne, Bagchi, Devika P, Kotzbauer, Paul T, Miller, Timothy M, Papy-Garcia, Dulce, Diamond, Marc I

“…Recent experimental evidence suggests that transcellular propagation of fibrillar protein aggregates drives the progression of neurodegenerative diseases in a…”
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Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain by Takeda, Shuko, Wegmann, Susanne, Cho, Hansang, DeVos, Sarah L., Commins, Caitlin, Roe, Allyson D., Nicholls, Samantha B., Carlson, George A., Pitstick, Rose, Nobuhara, Chloe K., Costantino, Isabel, Frosch, Matthew P., Müller, Daniel J., Irimia, Daniel, Hyman, Bradley T.

“…Tau pathology is known to spread in a hierarchical pattern in Alzheimer’s disease (AD) brain during disease progression, likely by trans-synaptic tau transfer…”
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Antisense Oligonucleotides: Treating Neurodegeneration at the Level of RNA by DeVos, Sarah L., Miller, Timothy M.

“…Adequate therapies are lacking for Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and other neurodegenerative…”
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Enhanced Tau Aggregation in the Presence of Amyloid β by Bennett, Rachel E, DeVos, Sarah L, Dujardin, Simon, Corjuc, Bianca, Gor, Rucha, Gonzalez, Jose, Roe, Allyson D, Frosch, Matthew P, Pitstick, Rose, Carlson, George A, Hyman, Bradley T

“…Amyloid plaques and neurofibrillary tangles co-occur in Alzheimer disease, but with different topological and temporal patterns. Whether these two lesions are…”
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Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain by DeVos, Sarah L, Corjuc, Bianca T, Oakley, Derek H, Nobuhara, Chloe K, Bannon, Riley N, Chase, Alison, Commins, Caitlin, Gonzalez, Jose A, Dooley, Patrick M, Frosch, Matthew P, Hyman, Bradley T

“…Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau aggregates as well as…”
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Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease by Eftekharzadeh, Bahareh, Daigle, J. Gavin, Kapinos, Larisa E., Coyne, Alyssa, Schiantarelli, Julia, Carlomagno, Yari, Cook, Casey, Miller, Sean J., Dujardin, Simon, Amaral, Ana S., Grima, Jonathan C., Bennett, Rachel E., Tepper, Katharina, DeTure, Michael, Vanderburg, Charles R., Corjuc, Bianca T., DeVos, Sarah L., Gonzalez, Jose Antonio, Chew, Jeannie, Vidensky, Svetlana, Gage, Fred H., Mertens, Jerome, Troncoso, Juan, Mandelkow, Eckhard, Salvatella, Xavier, Lim, Roderick Y.H., Petrucelli, Leonard, Wegmann, Susanne, Rothstein, Jeffrey D., Hyman, Bradley T.

“…Tau is the major constituent of neurofibrillary tangles in Alzheimer’s disease (AD), but the mechanism underlying tau-associated neural damage remains unclear…”
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Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system by Ramirez, Paulino, Zuniga, Gabrielle, Sun, Wenyan, Beckmann, Adrian, Ochoa, Elizabeth, DeVos, Sarah L., Hyman, Bradley, Chiu, Gabriel, Roy, Ethan R., Cao, Wei, Orr, Miranda, Buggia-Prevot, Virginie, Ray, William J., Frost, Bess

“…•Retrotransposon transcripts increase in the aging brain and in three mouse models of tauopathy.•Retrotransposon-encoded protein is elevated in brains of tau…”
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Characterization of TauC3 antibody and demonstration of its potential to block tau propagation by Nicholls, Samantha B, DeVos, Sarah L, Commins, Caitlin, Nobuhara, Chloe, Bennett, Rachel E, Corjuc, Diana L, Maury, Eduardo, Eftekharzadeh, Bahareh, Akingbade, Ololade, Fan, Zhanyun, Roe, Allyson D, Takeda, Shuko, Wegmann, Susanne, Hyman, Bradley T

“…The spread of neurofibrillary tangle (NFT) pathology through the human brain is a hallmark of Alzheimer's disease (AD), which is thought to be caused by the…”
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Direct intraventricular delivery of drugs to the rodent central nervous system by DeVos, Sarah L, Miller, Timothy M

“…Due to an inability to cross the blood brain barrier, certain drugs need to be directly delivered into the central nervous system (CNS). Our lab focuses…”
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Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro by Nobuhara, Chloe K., DeVos, Sarah L., Commins, Caitlin, Wegmann, Susanne, Moore, Benjamin D., Roe, Allyson D., Costantino, Isabel, Frosch, Matthew P., Pitstick, Rose, Carlson, George A., Hock, Christoph, Nitsch, Roger M., Montrasio, Fabio, Grimm, Jan, Cheung, Anne E., Dunah, Anthone W., Wittmann, Marion, Bussiere, Thierry, Weinreb, Paul H., Hyman, Bradley T., Takeda, Shuko

“…The clinical progression of Alzheimer disease (AD) is associated with the accumulation of tau neurofibrillary tangles, which may spread throughout the cortex…”
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Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo by DeVos, Sarah L, Corjuc, Bianca T, Commins, Caitlin, Dujardin, Simon, Bannon, Riley N, Corjuc, Diana, Moore, Benjamin D, Bennett, Rachel E, Jorfi, Mehdi, Gonzales, Jose A, Dooley, Patrick M, Roe, Allyson D, Pitstick, Rose, Irimia, Daniel, Frosch, Matthew P, Carlson, George A, Hyman, Bradley T

“…In vivo tau reduction strategies thus far have been studied in the absence of Aβ deposition. DeVos et al. suppress human tau in mice that develop both Aβ and…”
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Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients by Takeda, Shuko, Commins, Caitlin, DeVos, Sarah L., Nobuhara, Chloe K., Wegmann, Susanne, Roe, Allyson D., Costantino, Isabel, Fan, Zhanyun, Nicholls, Samantha B., Sherman, Alexis E., Trisini Lipsanopoulos, Ana T., Scherzer, Clemens R., Carlson, George A., Pitstick, Rose, Peskind, Elaine R., Raskind, Murray A., Li, Ge, Montine, Thomas J., Frosch, Matthew P., Hyman, Bradley T.

“…Objective Cerebrospinal fluid (CSF) tau is an excellent surrogate marker for assessing neuropathological changes that occur in Alzheimer's disease (AD)…”
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In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease by Meisl, Georg, Hidari, Eric, Allinson, Kieren, Rittman, Timothy, DeVos, Sarah L, Sanchez, Justin S, Xu, Catherine K, Duff, Karen E, Johnson, Keith A, Rowe, James B, Hyman, Bradley T, Knowles, Tuomas P J, Klenerman, David

“…Both the replication of protein aggregates and their spreading throughout the brain are implicated in the progression of Alzheimer’s disease (AD). However, the…”
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Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity by Wegmann, Susanne, Maury, Eduardo A, Kirk, Molly J, Saqran, Lubna, Roe, Allyson, DeVos, Sarah L, Nicholls, Samantha, Fan, Zhanyun, Takeda, Shuko, Cagsal-Getkin, Ozge, William, Christopher M, Spires-Jones, Tara L, Pitstick, Rose, Carlson, George A, Pooler, Amy M, Hyman, Bradley T

“…In Alzheimer's disease and tauopathies, tau protein aggregates into neurofibrillary tangles that progressively spread to synaptically connected brain regions…”
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Antisense reduction of tau in adult mice protects against seizures by DeVos, Sarah L, Goncharoff, Dustin K, Chen, Guo, Kebodeaux, Carey S, Yamada, Kaoru, Stewart, Floy R, Schuler, Dorothy R, Maloney, Susan E, Wozniak, David F, Rigo, Frank, Bennett, C Frank, Cirrito, John R, Holtzman, David M, Miller, Timothy M

“…Tau, a microtubule-associated protein, is implicated in the pathogenesis of Alzheimer's Disease (AD) in regard to both neurofibrillary tangle formation and…”
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Tau at the Crossroads between Neurotoxicity and Neuroprotection by DeVos, Sarah L., Hyman, Bradley T.

“…In contrast to the idea that tau phosphorylation is toxic, Ittner et al. (2016) recently showed that specific tau phosphorylation is neuroprotective,…”
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