Search Results - "DeSilva, Tara M."

Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination by Nemes-Baran, Ashley D., White, Donovan R., DeSilva, Tara M.

“…Oligodendrogenesis occurs during early postnatal development, coincident with neurogenesis and synaptogenesis, raising the possibility that microglia-dependent…”
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Microglia phagocytose oligodendrocyte progenitor cells and synapses during early postnatal development: implications for white versus gray matter maturation by Irfan, Muhammad, Evonuk, Kirsten S., DeSilva, Tara M.

“…Emerging roles for microglia in modifying normal brain development continue to provide new perspectives on the functions of this resident immune cell in the…”
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LRRK2 inhibition attenuates microglial inflammatory responses by Moehle, Mark S, Webber, Philip J, Tse, Tonia, Sukar, Nour, Standaert, David G, DeSilva, Tara M, Cowell, Rita M, West, Andrew B

“…Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease (PD), and common genetic variation in LRRK2 modifies…”
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Utility of the visual system to monitor neurodegeneration in multiple sclerosis by Mey, Gabrielle M, DeSilva, Tara M

“…Neurodegeneration occurs early in the multiple sclerosis (MS) disease course and is an important driver of permanent disability. Current immunomodulatory…”
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Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination by Evonuk, Kirsten S, Baker, Brandi J, Doyle, Ryan E, Moseley, Carson E, Sestero, Christine M, Johnston, Bryce P, De Sarno, Patrizia, Tang, Andrew, Gembitsky, Igor, Hewett, Sandra J, Weaver, Casey T, Raman, Chander, DeSilva, Tara M

“…T cell infiltration into the CNS is a significant underlying pathogenesis in autoimmune inflammatory demyelinating diseases. Several lines of evidence suggest…”
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Hyperoxia Induced Hypomyelination by Song, Weilin, Hoppe, George, Hanna, Demiana, DeSilva, Tara M, Sears, Jonathan E

“…We asked whether hyperoxia might induce hypomyelination of the corpus callosum, clinically described as periventricular leukomalacia (PVL) of the severely…”
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Quantification of microglial contact and engulfment of oligodendrocyte progenitor cells in the rodent brain by Nemes-Baran, Ashley D., DeSilva, Tara M.

“…Microglia have emerged as essential regulators of neurodevelopment by phagocytosing synapses. Recently, we showed that microglia engulf viable oligodendrocyte…”
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Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development by DeSilva, Tara M., Borenstein, Natalia S., Volpe, Joseph J., Kinney, Hannah C., Rosenberg, Paul A.

“…The major regulators of synaptic glutamate in the cerebral cortex are the excitatory amino acid transporters 1–3 (EAAT1–3). In this study, we determined the…”
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Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation by Evonuk, Kirsten S, Doyle, Ryan E, Moseley, Carson E, Thornell, Ian M, Adler, Keith, Bingaman, Amanda M, Bevensee, Mark O, Weaver, Casey T, Min, Booki, DeSilva, Tara M

“…Glutamate dysregulation occurs in multiple sclerosis (MS), but whether excitotoxic mechanisms in mature oligodendrocytes contribute to demyelination and axonal…”
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Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis by Mey, Gabrielle M, Evonuk, Kirsten S, Chappell, McKenzie K, Wolfe, Laura M, Singh, Rupesh, Batoki, Julia C, Yu, Minzhong, Peachey, Neal S, Anand-Apte, Bela, Bermel, Robert, Ontaneda, Daniel, Nakamura, Kunio, Mahajan, Kedar R, DeSilva, Tara M

“…Thalamic volume is associated with clinical disability in multiple sclerosis (MS) and is vulnerable to secondary neurodegeneration due to its extensive…”
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Axonal development in the cerebral white matter of the human fetus and infant by Haynes, Robin L., Borenstein, Natalia S., Desilva, Tara M., Folkerth, Rebecca D., Liu, Lena G., Volpe, Joseph J., Kinney, Hannah C.

“…After completion of neuronal migration to form the cerebral cortex, axons undergo rapid elongation to their intra‐ and subcortical targets, from midgestation…”
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Correction to: Visual imaging as a predictor of neurodegeneration in experimental autoimmune demyelination and multiple sclerosis by Mey, Gabrielle M, Evonuk, Kirsten S, Chappell, McKenzie K, Wolfe, Laura M, Singh, Rupesh, Batoki, Julia C, Yu, Minzhong, Peachey, Neal S, Anand-Apte, Bela, Bermel, Robert, Ontaneda, Daniel, Nakamura, Kunio, Mahajan, Kedar R, DeSilva, Tara M

“…Dr. Robert Bermel also discloses research support from Biogen, Genentech, and Novartis, and shares rights to intellectual property underlying the Multiple…”
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Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS by Watson, Jennifer A, Bhattacharyya, Bula J, Vaden, Jada H, Wilson, Julie A, Icyuz, Mert, Howard, Alan D, Phillips, Edward, DeSilva, Tara M, Siegal, Gene P, Bean, Andrew J, King, Gwendalyn D, Phillips, Scott E, Miller, Richard J, Wilson, Scott M

“…Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this…”
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Cellular and subcellular mRNA localization of glutamate transporter isoforms GLT1a and GLT1b in rat brain by in situ hybridization by Berger, Urs V., DeSilva, Tara M., Chen, Weizhi, Rosenberg, Paul A.

“…GLT1, the predominant glutamate transporter of the forebrain, exists in two splice variant isoforms, i.e., GLT1a and GLT1b. Although GLT1 was originally…”
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Remyelinating strategies: What can be learned from normal brain development by Shelestak, John, Irfan, Muhammad, DeSilva, Tara M.

“…Multiple sclerosis (MS) is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). Immunomodulatory therapies are…”
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The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter by Desilva, Tara M., Kinney, Hannah C., Borenstein, Natalia S., Trachtenberg, Felicia L., Irwin, Nina, Volpe, Joseph J., Rosenberg, Paul A.

“…The major brain abnormality underlying cerebral palsy in premature infants is periventricular leukomalacia (PVL), a lesion of the immature cerebral white…”
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Endothelial-to-mesenchymal transition in multiple sclerosis: Good cells gone bad by Mey, Gabrielle M., DeSilva, Tara M.

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Making myelin regenerate: Factors to consider by Huang, Jeffrey K., DeSilva, Tara M.

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Neurodegeneration in multiple sclerosis by Mey, Gabrielle M., Mahajan, Kedar R., DeSilva, Tara M.

“…Axonal loss in multiple sclerosis (MS) is a key component of disease progression and permanent neurologic disability. MS is a heterogeneous demyelinating and…”
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Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia by Desilva, Tara M., Billiards, Saraid S., Borenstein, Natalia S., Trachtenberg, Felicia L., Volpe, Joseph J., Kinney, Hannah C., Rosenberg, Paul A.

“…The major neuropathological correlate of cerebral palsy in premature infants is periventricular leukomalacia (PVL), a disorder of the immature cerebral white…”
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