Search Results - "DeSantis, Lauren C"

Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance by Flores, Anabel, Argetsinger, Lawrence S, Stadler, Lukas K J, Malaga, Alvaro E, Vander, Paul B, DeSantis, Lauren C, Joe, Ray M, Cline, Joel M, Keogh, Julia M, Henning, Elana, Barroso, Ines, Mendes de Oliveira, Edson, Chandrashekar, Gowri, Clutter, Erik S, Hu, Yixin, Stuckey, Jeanne, Farooqi, I Sadaf, Myers, Jr, Martin G, Carter-Su, Christin

“…Disruption of the adaptor protein SH2B1 (SH2-B, PSM) is associated with severe obesity, insulin resistance, and neurobehavioral abnormalities in mice and…”
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Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity by Cote, Jessica L, Argetsinger, Lawrence S, Flores, Anabel, Rupp, Alan C, Cline, Joel M, DeSantis, Lauren C, Bedard, Alexander H, Bagchi, Devika P, Vander, Paul B, Cacciaglia, Abrielle M, Clutter, Erik S, Chandrashekar, Gowri, MacDougald, Ormond A, Myers, Jr, Martin G, Carter-Su, Christin

“…Mice lacking SH2B1 and humans with variants of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein that is recruited to the…”
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Mutations in the PH Domain of SH2B1 Result in Energy Imbalance and/or Impaired Glucose Metabolism by Flores, Anabel, DeSantis, Lauren C., Malaga, Alvaro, Clutter, Erik S., Argetsinger, Lawrence S., Myers, Martin G., Carter‐Su, Christin

“…Mutations in the scaffold protein SH2B1 have been identified in individuals with severe early‐onset childhood obesity, insulin resistance, and hyperphagia…”
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