Search Results - "DeSantiago, Jaime"

Loss of p21-activated kinase 1 (Pak1) promotes atrial arrhythmic activity by DeSantiago, Jaime, Bare, Dan J., Varma, Disha, Solaro, R. John, Arora, Rishi, Banach, Kathrin

“…Atrial fibrillation (AF) is initiated through arrhythmic atrial excitation from outside the sinus node or remodeling of atrial tissue that allows reentry of…”
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p21-Activated kinase1 (Pak1) is a negative regulator of NADPH-oxidase 2 in ventricular myocytes by DeSantiago, Jaime, Bare, Dan J, Xiao, Lei, Ke, Yunbo, Solaro, R. John, Banach, Kathrin

“…Abstract Ischemic conditions reduce the activity of the p21-activated kinase (Pak1) resulting in increased arrhythmic activity. Triggered arrhythmic activity…”
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Arrhythmogenic Effects of β2-Adrenergic Stimulation in the Failing Heart Are Attributable to Enhanced Sarcoplasmic Reticulum Ca Load by DeSantiago, Jaime, Ai, Xun, Islam, Mohammed, Acuna, Georgia, Ziolo, Mark T, Bers, Donald M, Pogwizd, Steven M

“…Ventricular tachycardia in heart failure (HF) can initiate by nonreentrant mechanisms such as delayed afterdepolarizations. In an arrhythmogenic rabbit model…”
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The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+–Ca2+ exchanger function by Julio Altamirano, Yanxia Li, Jaime DeSantiago, Valentino Piacentino, 3rd, Steven R. Houser, Donald M. Bers

“…Glycoside-induced cardiac inotropy has traditionally been attributed to direct Na + –K + -ATPase inhibition, causing increased intracellular [Na + ] and…”
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CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation by Picht, Eckard, DeSantiago, Jaime, Huke, Sabine, Kaetzel, Marcia A, Dedman, John R, Bers, Donald M

“…Abstract Cardiac Ca2+ /calmodulin-dependent protein kinase II (CaMKII) in heart has been implicated in Ca2+ current ( ICa ) facilitation, enhanced sarcoplasmic…”
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Relevance of InsP3 Receptor ROS Regulation in Atrial Myocytes by Desantiago, Jaime, Banach, Kathrin

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Akt regulates L-type Ca²⁺ channel activity by modulating Cavα1 protein stability by Catalucci, Daniele, Zhang, Deng-Hong, DeSantiago, Jaime, Aimond, Franck, Barbara, Guillaume, Chemin, Jean, Bonci, Désiré, Picht, Eckard, Rusconi, Francesca, Dalton, Nancy D, Peterson, Kirk L, Richard, Sylvain, Bers, Donald M, Brown, Joan Heller, Condorelli, Gianluigi

“…The insulin IGF-1-PI3K-Akt signaling pathway has been suggested to improve cardiac inotropism and increase Ca²⁺ handling through the effects of the protein…”
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Abstract 4138278: A Titin Missense Variant Causes Atrial Fibrillation by Arif, Mahmud, Chen, Hanna, Hill, Michael, Barney, Miles, Sridhar, Arvind, Owais, Asia, DeSantiago, Jaime, Darbar, Dawood

“…Abstract only Background: Rare loss-of-function variants in TTN , the gene encoding the sarcomeric protein titin, have been causally associated with atrial…”
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Abstract 4146109: Genetic Mouse Models of Obesity may provide mechanistic insights into atrial myopathy and atrial fibrillation: Insights from Mc4r -KO Mice by Sridhar, Arvind, DeSantiago, Jaime, Arif, Mahmud, Owais, Asia, Barney, Miles, Chen, Hanna, Baskaran, Abhinaya, Hong, Liang, McCauley, Mark, Darbar, Dawood

“…Abstract only Background: Although a causal relationship between diet-induced obesity (DIO) and atrial fibrillation (AF) has been established, the underlying…”
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Abstract 4141396: Activation of the Wnt Signaling Pathway Links Atrial Myopathy to Atrial Fibrillation in Lamin A/C Heart Disease by Owais, Asia, Chen, Hanna, Chen, Yining, Sridhar, Arvind, Barney, Miles, Baskaran, Abhinaya, DeSantiago, Jaime, Arif, Mahmud, Darbar, Dawood

“…Abstract only Objective: Pathogenic variants in LMNA are associated with early-onset atrial fibrillation (EOAF) but the pathophysiological mechanisms by which…”
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Isolated Cardiac Ryanodine Receptor Function Varies Between Mammals by Carvajal, Catherine, Yan, Jiajie, Nani, Alma, DeSantiago, Jaime, Wan, Xiaoping, Deschenes, Isabelle, Ai, Xun, Fill, Michael

“…Concerted robust opening of cardiac ryanodine receptors’ (RyR2) Ca 2+ release 1oplasmic reticulum (SR) is fundamental for normal systolic cardiac function…”
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Abstract 4147856: A TTN Frameshift Mutation Leads to Dysfunctional Sarcomere and Calcium Handling in iPSC-derived Atrial Cardiomyocytes by Baskaran, Abhinaya, Arif, Mahmud, Chen, Hanna, Hill, Michael, Barney, Miles, Owais, Asia, Sridhar, Arvind, DeSantiago, Jaime, Shah, Anish, Griza, Decebal, Chen, Yining, Diaz, Annette, Darbar, Dawood

“…Abstract only Background: Increasingly, rare variants in genes encoding sarcomeric proteins like titin, have been associated with early-onset atrial…”
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Abstract 4140554: Epigenetic Activation of Endothelial to Mesenchymal Transition Links Endothelial Dysfunction to Atrial Fibrillation in Lamin A/C Cardiomyopathy by Owais, Asia, Chen, Hanna, Barney, Miles, Sridhar, Arvind, Baskaran, Abhinaya, Kortan, Elif, DeSantiago, Jaime, Arif, Mahmud, Islam, Abul, Maienschein-Cline, Mark, Ong, Sang, Darbar, Dawood

“…Abstract only Introduction: Accumulating evidence supports a bidirectional association between atrial fibrillation (AF), and endothelial cell (EC) dysfunction;…”
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Electrical and Calcium Transient Alternans in Cell Pairs and Intact Atrium by Banach, Kathrin, DeSantiago, Jaime, Blatter, Lothar A.

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Abstract 16646: Inositol 1,4,5-Trisphosphate Receptor Regulation in Atrial Myocyte Microdomains by DeSantiago, Jaime, Varma, Disha, Blatter, Lothar, Banach, Kathrin

“…IntroductionInsP3 receptor type 2 (InsP3R2) is up-regulated in patients with atrial fibrillation (AF) and InsP3-induced Ca release (IICR) is linked to an…”
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Modulation of NOX2 causes obesity-mediated atrial fibrillation by Sridhar, Arvind, DeSantiago, Jaime, Chen, Hanna, Pavel, Mahmud Arif, Ly, Olivia, Owais, Asia, Barney, Miles, Jousma, Jordan, Nukala, Sarath Babu, Abdelhady, Khaled, Massad, Malek, Rizkallah, Lona Ernst, Ong, Sang-Ging, Rehman, Jalees, Darbar, Dawood

“…Obesity is linked to an increased risk of atrial fibrillation (AF) via increased oxidative stress. While NADPH oxidase 2 (NOX2), a major source of oxidative…”
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Inositol 1,4,5-trisphosphate receptor - reactive oxygen signaling domain regulates excitation-contraction coupling in atrial myocytes by Varma, Disha, Almeida, Jonathas F.Q., DeSantiago, Jaime, Blatter, Lothar A., Banach, Kathrin

“…The inositol 1,4,5-trisphosphate receptor (InsP3R) is up-regulated in patients with atrial fibrillation (AF) and InsP3-induced Ca2+ release (IICR) is linked to…”
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Abstract 14079: Inhibition of NOX2 Prevents Obesity-Mediated Atrial Fibrillation by Sridhar, Arvind, DeSantiago, Jaime, Arif, Mahmud, Ly, Olivia T, Chen, Hanna, Barney, Miles, Owais, Asia, Jousma, Jordan, Nukala, Sarath Babu B, Wang, Xinge, Abdelhady, khaled, Massad, Malek G, Rizkallah, Lona Ernst, Ong, Sang-Ging, Rehman, Jalees, Darbar, Dawood

“…Abstract only Introduction: Obesity is an independent risk factor for atrial fibrillation (AF). While oxidative stress plays an important role in…”
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Ischemia/Reperfusion injury protection by mesenchymal stem cell derived antioxidant capacity by DeSantiago, Jaime, Bare, Dan J, Banach, Kathrin

“…Mesenchymal stem cell (MSC) transplantation after ischemia/reperfusion (I/R) injury reduces infarct size and improves cardiac function. We used mouse…”
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Cardiac Alternans Do Not Rely on Diastolic Sarcoplasmic Reticulum Calcium Content Fluctuations by Picht, Eckard, DeSantiago, Jaime, Blatter, Lothar A, Bers, Donald M

“…Cardiac alternans are thought to be a precursor to life-threatening arrhythmias. Previous studies suggested that alterations in sarcoplasmic reticulum (SR) Ca…”
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