Search Results - "DeSante, K. A."

Confidence interval criteria for assessment of dose proportionality by SMITH, Brian P, VANDENHENDE, Francois R, DESANTE, Karl A, FARID, Nagy A, WELCH, Pamela A, CALLAGHAN, John T, FORGUE, S. Thomas

“…The aim of this work was a pragmatic, statistically sound and clinically relevant approach to dose-proportionality analyses that is compatible with common…”
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Pharmacokinetics, Safety, and Tolerability of Atomoxetine and Effect of CYP2D610/10 Genotype in Healthy Japanese Men by Matsui, A., Azuma, J., Witcher, J. W., Long, A. J., Sauer, J.-M., Smith, B. P., DeSante, K. A., Read, H. A., Takahashi, M., Nakano, M.

“…Atomoxetine is a cytochrome P4502D6 (CYP2D6) substrate. The reduced-activity CYP2D6*10 allele is particularly prevalent in the Japanese population and may…”
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Sensitive and specific radioimmunoassay for fialuridine: initial assessment of pharmacokinetics after single oral doses to healthy volunteers by BOWSHER, R. R, COMPTON, J. A, KIRKWOOD, J. A, PLACE, G. D, JONES, C. D, MABRY, T. E, HYSLOP, D. L, HATCHER, B. L, DESANTE, K. A

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Pharmacokinetics of dirithromycin by Sides, G D, Cerimele, B J, Black, H R, Busch, U, DeSante, K A

“…Dirithromycin is a new member of the macrolide class of antibiotics and has been developed for oral administration. Dirithromycin is a 14-membered lactone ring…”
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Why rate of absorption inferences in single dose bioequivalence studies are often inappropriate by BASSON, R. P, GHOSH, A, CERIMELE, B. J, DESANTE, K. A, HOWEY, D. C

“…Peak drug concentration (Cmax) measures the extremity of drug exposure and is a secondary indicator of the extent of absorption after area under the…”
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Tmax : an unconfounded metric for rate of absorption in single dose bioequivalence studies by BASSON, R. P, CERIMELE, B. J, DESANTE, K. A, HOWEY, D. C

“…While peak drug concentration (Cmax) is recognized to be contaminated by the extent of absorption, it has long served as the indicator of change in absorption…”
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Disposition of zatosetron, a serotonin (5-HT3) receptor antagonist, in humans by Franz, P M, Mattiuz, E L, Hatcher, B L, DeSante, K A, Breau, A P, Occolowitz, J L, Dorman, D E, Schmid, C R, Goldberg, M J, Rubin, A

“…Zatosetron is being tested clinically as an antianxiety agent; it is a highly selective antagonist of the serotonin 5-HT3 receptor, with minimal agonist…”
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Effects of renal dysfunction on the pharmacokinetics of loracarbef by Therasse, D G, Farlow, D S, Davidson, R L, Quadracci, L J, Hatcher, B L, Cerimele, B J, DeSante, K A

“…Loracarbef, the first carbacephem antibiotic to undergo clinical development, is excreted primarily unchanged in the urine (> 90%). Data analyzed from subjects…”
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The penetration of dirithromycin into bronchoalveolar lavage fluid and alveolar macrophages by Baughman, R P, DeSante, K A, Lanier, T L, Conforti, P M, Sides, G D

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Clinical pharmacokinetics of pinacidil, a potassium channel opener, in hypertension by Goldberg, M R, Rockhold, F W, Thompson, W L, DeSante, K A

“…Pinacidil is a potassium channel opener that decreases blood pressure by reducing peripheral arterial resistance. In two multicenter trials, we studied the…”
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Disposition of [14C]pinacidil in humans by DeLong, A F, Oldham, S W, DeSante, K A, Nell, G, Henry, D P

“…Pinacidil [(+/-)-2-cyano-1-(4-pyridyl)-3-(1,2,2-trimethylpropyl)guanidine monohydrate] is a novel, direct-acting vasodilator antihypertensive agent. The cyano…”
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Disposition in humans of racemic picenadol, an opioid analgesic by Franz, P M, Anliker, S L, Callaghan, J T, DeSante, K A, Dhahir, P H, Nelson, R L, Rubin, A

“…Racemic picenadol is being tested clinically as an analgesic. The (+)-enantiomer of picenadol is an opioid agonist and the (-)-enantiomer is a weak…”
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Sensitive, specific radioimmunoassay for quantifying pergolide in plasma by Bowsher, R R, Apathy, J M, Compton, J A, Wolen, R L, Carlson, K H, DeSante, K A

“…Pergolide, a synthetic ergoline with potent dopaminergic activity, is used to treat Parkinson disease. The low plasma concentrations of pergolide achieved…”
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Pharmacokinetics of cefaclor AF: effects of age, antacids and H2-receptor antagonists by Satterwhite, J H, Cerimele, B J, Coleman, D L, Hatcher, B L, Kisicki, J, DeSante, K A

“…The pharmacokinetics and bioavailability of cefaclor advanced formulation (cefaclor AF) were investigated in two studies, one comparing healthy elderly and…”
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A comprehensive review of the clinical pharmacology and pharmacokinetics of cefaclor by Sides, G D, Franson, T R, DeSante, K A, Black, H R

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Effect of probenecid on the pharmacokinetics of moxalactam by DeSante, K A, Israel, K S, Brier, G L, Wolny, J D, Hatcher, B L

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Single- and multiple-dose pharmacokinetics of moxalactam in normal subjects by Israel, K S, Black, H R, Brier, G L, Wolny, J D, DeSante, K A

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Bioavailability and pharmacokinetics of prednisone in humans by Disanto, A R, Desante, K A

“…In a clinical study involving 22 normal adult volunteers, the bioavailability and pharmacokinetics of prednisone tablets with varying dissolution rates were…”
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Lincomycin serum and saliva concentrations after intramuscular injection of high doses by Smith, R B, Lummis, W L, Monovich, R E, DeSante, K A

“…Serum and saliva levels of lincomycin were determined in 15 normal adult male volunteers after a single intramuscular injection of 600, 1000, or 1500 mg…”
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Pharmacokinetic profile of loracarbef by DeSante, K A, Zeckel, M L

“…Loracarbef, the first beta-lactam antibiotic of the carbacephem class to undergo clinical evaluation, has been the subject of extensive clinical pharmacology…”
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