Search Results - "DeRuisseau, Keith C"

Effects of Prolonged Dietary Curcumin Exposure on Skeletal Muscle Biochemical and Functional Responses of Aged Male Rats by Receno, Candace N, Liang, Chen, Korol, Donna L, Atalay, Mustafa, Heffernan, Kevin S, Brutsaert, Tom D, DeRuisseau, Keith C

“…Oxidative stress resulting from decreased antioxidant protection and increased reactive oxygen and nitrogen species (RONS) production may contribute to muscle…”
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Mechanisms of disuse muscle atrophy: role of oxidative stress by Powers, Scott K, Kavazis, Andreas N, DeRuisseau, Keith C

“…Prolonged periods of skeletal muscle inactivity lead to a loss of muscle protein and strength. Advances in cell biology have progressed our understanding of…”
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Neural deficits contribute to respiratory insufficiency in Pompe disease by DeRuisseau, Lara R, Fuller, David D, Qiu, Kai, DeRuisseau, Keith C, Donnelly, William H. Jr, Mah, Cathryn, Reier, Paul J, Byrne, Barry J

“…Pompe disease is a severe form of muscular dystrophy due to glycogen accumulation in all tissues, especially striated muscle. Disease severity is directly…”
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Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress by Hulmi, Juha J., Hentilä, Jaakko, DeRuisseau, Keith C., Oliveira, Bernardo M., Papaioannou, Konstantinos G., Autio, Reija, Kujala, Urho M., Ritvos, Olli, Kainulainen, Heikki, Korkmaz, Ayhan, Atalay, Mustafa

“…Protein homeostasis in cells, proteostasis, is maintained through several integrated processes and pathways and its dysregulation may mediate pathology in many…”
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Caspase-3 Regulation of Diaphragm Myonuclear Domain during Mechanical Ventilation-induced Atrophy by McClung, Joseph M, Kavazis, Andreas N, DeRuisseau, Keith C, Falk, Darin J, Deering, Melissa A, Lee, Youngil, Sugiura, Takao, Powers, Scott K

“…Unloading the diaphragm via mechanical ventilation (MV) results in rapid diaphragmatic fiber atrophy. It is unknown whether the myonuclear domain (cytoplasmic…”
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Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation by McClung, Joseph M, Van Gammeren, Darin, Whidden, Melissa A, Falk, Darin J, Kavazis, Andreas N, Hudson, Matt B, Gayan-Ramirez, Ghislaine, Decramer, Marc, DeRuisseau, Keith C, Powers, Scott K

“…OBJECTIVE:To investigate whether apocynin protects the diaphragm from wasting and oxidative stress during mechanical ventilation (MV). DESIGN:Prospective,…”
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Trolox Attenuates Mechanical Ventilation-induced Diaphragmatic Dysfunction and Proteolysis by Betters, Jenna L, Criswell, David S, Shanely, R. Andrew, Van Gammeren, Darin, Falk, Darin, DeRuisseau, Keith C, Deering, Melissa, Yimlamai, Tossaporn, Powers, Scott K

“…Prolonged mechanical ventilation results in diaphragmatic oxidative injury, elevated proteolysis, fiber atrophy, and reduced force-generating capacity. We…”
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Oxidant production and SOD1 protein expression in single skeletal myofibers from Down syndrome mice by Cowley, Patrick M., Nair, Divya R., DeRuisseau, Lara R., Keslacy, Stefan, Atalay, Mustafa, DeRuisseau, Keith C.

“…Down syndrome (DS) is a genetic condition caused by the triplication of chromosome 21. Persons with DS exhibit pronounced muscle weakness, which also occurs in…”
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Mechanical ventilation-induced oxidative stress in the diaphragm by Zergeroglu, Murat A, McKenzie, Michael J, Shanely, R. Andrew, Van Gammeren, Darin, DeRuisseau, Keith C, Powers, Scott K

“…1 Departments of Exercise and Sport Sciences and Physiology, Center for Exercise Science, University of Florida, Gainesville, Florida 32611; and 2 Faculty of…”
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Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus muscle by DeRuisseau, Keith C., Kavazis, Andreas N., Powers, Scott K.

“…Aging-related alterations of the ubiquitin proteasome pathway (UPP) have been reported in locomotor skeletal muscle. Specifically, declines in proteasome…”
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Plantaris muscle of aged rats demonstrates iron accumulation and altered expression of iron regulation proteins by Jung, Seung H., DeRuisseau, Lara R., Kavazis, Andreas N., DeRuisseau, Keith C.

“…Increased free radical production and oxidative damage in ageing muscle may be a contributing factor to the development of sarcopenia. It has been suggested…”
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Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction-induced fatigue or recovery by McClung, Joseph M., DeRuisseau, Keith C., Whidden, Melissa A., Van Remmen, Holly, Richardson, Arlan, Song, Wook, Vrabas, Ioannis S., Powers, Scott K.

“…Low levels of reactive oxygen species (ROS) production are necessary to optimize muscle force production in unfatigued muscle. In contrast, sustained high…”
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Diaphragm Unloading via Controlled Mechanical Ventilation Alters the Gene Expression Profile by DeRuisseau, Keith C, Shanely, R. Andrew, Akunuri, Nagabhavani, Hamilton, Marc T, Van Gammeren, Darin, Zergeroglu, A. Murat, McKenzie, Michael, Powers, Scott K

“…Prolonged controlled mechanical ventilation results in diaphragmatic inactivity and promotes oxidative injury, atrophy, and contractile dysfunction in this…”
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In vivo inhibition of nitric oxide synthase impairs upregulation of contractile protein mRNA in overloaded plantaris muscle by Sellman, Jeff E, DeRuisseau, Keith C, Betters, Jenna L, Lira, Vitor A, Soltow, Quinlyn A, Selsby, Joshua T, Criswell, David S

“…Center for Exercise Science, University of Florida, Gainesville, Florida Submitted 1 August 2005 ; accepted in final form 14 September 2005 Inhibition of…”
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Senescent hearts from male Ts65Dn mice exhibit preserved function but altered size and nicotinamide adenine dinucleotide pathway signaling by Brandauer, Josef, Receno, Candace N, Anyaoku, Cynthia, Cooke, Lauren E, Schwarzer, Hannalyn M, DeRuisseau, Keith C, Cunningham, Caitlin M, DeRuisseau, Lara R

“…Down syndrome (DS) is associated with congenital heart defects at birth, but cardiac function has not been assessed at older ages. We used the Ts65Dn mouse, a…”
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Metallothionein deficiency leads to soleus muscle contractile dysfunction following acute spinal cord injury in mice by DeRuisseau, Lara R, Recca, Daniel M, Mogle, Jacqueline A, Zoccolillo, Michelle, DeRuisseau, Keith C

“…Metallothionein (MT) is a small molecular weight protein possessing metal binding and free radical scavenging properties. We hypothesized that MT-1/MT-2 null…”
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Functional and biochemical responses of skeletal muscle following a moderate degree of systemic iron loading in mice by Liang, Chen, Mickey, Marisa C, Receno, Candace N, Atalay, Mustafa, DeRuisseau, Keith C

“…Excessive iron loading may cause skeletal muscle atrophy and weakness because of its free radical generating properties. To determine whether a clinically…”
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Vitamin D Supplementation Partially Rescues Breathing Deficits in Mecp2 Hemizygous Null Mice, a Model of Rett Syndrome by DeRuisseau, Lara R., Mora, Lyna, Zheng, Ash, Amin, B. S., Bonsu, Samuel O., Cilhoroz, Burak T., DeRuisseau, Keith C., Kowalchuk, Angelica M., MacDonald, Jessica L.

“…Rett syndrome (RTT) is a severe X‐linked progressive neurodevelopmental disorder affecting ~1 in 10,000 females. It is the second most common genetic cause of…”
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Sweat iron and zinc losses during prolonged exercise by DeRuisseau, Keith C, Cheuvront, Samuel N, Haymes, Emily M, Sharp, Regina G

“…The purpose of this study was to examine the effects of a 2-hour exercise bout on sweat iron and zinc concentrations and losses in males and females. Nine male…”
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Aging-related changes in the iron status of skeletal muscle by DeRuisseau, Keith C., Park, Young-Min, DeRuisseau, Lara R., Cowley, Patrick M., Fazen, Christopher H., Doyle, Robert P.

“…The rise in non-heme iron (NHI) concentration observed in skeletal muscle of aging rodents is thought to contribute to the development of sarcopenia. The…”
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